8D23

Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT529

Summary for 8D23

Entry DOI	10.2210/pdb8d23/pdb
Descriptor	N-acetyltransferase Eis, 1-{2-[(3-chlorophenyl)methoxy]phenyl}-N-[(pyridin-3-yl)methyl]methanamine, GLYCEROL, ... (4 entities in total)
Functional Keywords	resistance, aminoglycoside, enzyme, inhibitor, acetyl transfer, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mycobacterium tuberculosis H37Rv
Total number of polymer chains	1
Total formula weight	46430.04
Authors	Pang, A.H.,Punetha, A.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2022-05-27, release date: 2022-09-14, Last modification date: 2023-10-18)
Primary citation	Pang, A.H.,Green, K.D.,Chandrika, N.T.,Garzan, A.,Punetha, A.,Holbrook, S.Y.L.,Willby, M.J.,Posey, J.E.,Tsodikov, O.V.,Garneau-Tsodikova, S. Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity. Eur.J.Med.Chem., 242:114698-114698, 2022 Cited by PubMed: 36037791 DOI: 10.1016/j.ejmech.2022.114698 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.14 Å)

Structure validation