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3MCV

Structure of PTR1 from Trypanosoma brucei in ternary complex with 2,4-diamino-5-[2-(2,5-dimethoxyphenyl)ethyl]thieno[2,3-d]-pyrimidine and NADP+

Summary for 3MCV
Entry DOI10.2210/pdb3mcv/pdb
Related2x9g 2x9n 2x9v
DescriptorPteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[2-(2,5-dimethoxyphenyl)ethyl]thieno[2,3-d]pyrimidine-2,4-diamine, ... (5 entities in total)
Functional Keywordspteridine reductase, antifolate, oxidoreductase
Biological sourceTrypanosoma brucei brucei
Total number of polymer chains4
Total formula weight127210.58
Authors
Tulloch, L.B.,Hunter, W.N. (deposition date: 2010-03-29, release date: 2010-06-02, Last modification date: 2024-02-21)
Primary citationDawson, A.,Tulloch, L.B.,Barrack, K.L.,Hunter, W.N.
High-resolution structures of Trypanosoma brucei pteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug target.
Acta Crystallogr.,Sect.D, 66:1334-1340, 2010
Cited by
PubMed: 21123874
DOI: 10.1107/S0907444910040886
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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