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3MCV

Structure of PTR1 from Trypanosoma brucei in ternary complex with 2,4-diamino-5-[2-(2,5-dimethoxyphenyl)ethyl]thieno[2,3-d]-pyrimidine and NADP+

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, DPteridine reductasepolymer28830669.84UniProt (O76290)
Pfam (PF13561)
In PDB
Trypanosoma brucei brucei
2A, B, C, DNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer743.44Chemie (NAP)
3A, B, C, D5-[2-(2,5-dimethoxyphenyl)ethyl]thieno[2,3-d]pyrimidine-2,4-diaminenon-polymer330.44Chemie (MCV)
4A, B, DACETATE IONnon-polymer59.04Chemie (ACT)
5waterwater18.0793Chemie (HOH)
Sequence modifications
A, B, C, D: 1 - 268 (UniProt: O76290)
PDBExternal DatabaseDetails
Met -19-expression tag
Gly -18-expression tag
Ser -17-expression tag
Ser -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
His -12-expression tag
His -11-expression tag
His -10-expression tag
Ser -9-expression tag
Ser -8-expression tag
Gly -7-expression tag
Leu -6-expression tag
Val -5-expression tag
Pro -4-expression tag
Arg -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
His 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight122679.2
Non-Polymers*Number of molecules12
Total formula weight4531.4
All*Total formula weight127210.6
*Water molecules are not included.

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PDB entries from 2024-06-12

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