2E6A

Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with orotate

Summary for 2E6A

• Entry DOI: 10.2210/pdb2e6a/pdb
• Related: 2DJL 2DJX 2E68 2E6D 2E6F
• Descriptor: Dihydroorotate dehydrogenase, COBALT HEXAMMINE(III), FLAVIN MONONUCLEOTIDE, ... (6 entities in total)
• Functional Keywords: chagas disease, pyrimidine biosynthesis, dihydroorotate dehydrogenase, fumarate reductase, energy metabolism, redox homeostasis, flavoprotein, oxidoreductase
• Biological source: Trypanosoma cruzi
• Cellular location: Cytoplasm (By similarity): Q4D3W2
• Total number of polymer chains: 2
• Total formula weight: 70151.23

Authors

Inaoka, D.K.,Shimizu, H.,Sakamoto, K.,Shiba, T.,Kurisu, G.,Nara, T.,Aoki, T.,Harada, S.,Kita, K. (deposition date: 2006-12-26, release date: 2008-01-15, Last modification date: 2024-10-30)

• Primary citation: Inaoka, D.K.,Shimizu, H.,Sakamoto, K.,Shiba, T.,Kurisu, G.,Nara, T.,Aoki, T.,Harada, S.,Kita, K.; Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with orotate; To be Published,

Experimental method

X-RAY DIFFRACTION (1.64 Å)