8D25
Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT530
Summary for 8D25
Entry DOI | 10.2210/pdb8d25/pdb |
Descriptor | N-acetyltransferase Eis, 1-{2-[(3-chlorophenyl)methoxy]phenyl}-N-[(pyridin-4-yl)methyl]methanamine, GLYCEROL, ... (4 entities in total) |
Functional Keywords | resistance, aminoglycoside, enzyme, inhibitor, acetyl transfer, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mycobacterium tuberculosis H37Rv |
Total number of polymer chains | 1 |
Total formula weight | 46430.04 |
Authors | Pang, A.H.,Punetha, A.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2022-05-27, release date: 2022-09-14, Last modification date: 2023-10-18) |
Primary citation | Pang, A.H.,Green, K.D.,Chandrika, N.T.,Garzan, A.,Punetha, A.,Holbrook, S.Y.L.,Willby, M.J.,Posey, J.E.,Tsodikov, O.V.,Garneau-Tsodikova, S. Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity. Eur.J.Med.Chem., 242:114698-114698, 2022 Cited by PubMed: 36037791DOI: 10.1016/j.ejmech.2022.114698 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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