2ZJL
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![BU of 2zjl by Molmil](/molmil-images/mine/2zjl) | Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-bromo-2,3-dimethoxy-benzyl)-piperidin-4-yl]-4-mercapto-butyramide | 分子名称: | Beta-secretase 1, N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide | 著者 | Randal, M, Lam, M.B, Lu, W, Romanowski, M.J. | 登録日 | 2008-03-07 | 公開日 | 2009-01-20 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Fragment-based discovery of novel BACE1 inhibitors using Tethering technology To be Published
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6H3F
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![BU of 6h3f by Molmil](/molmil-images/mine/6h3f) | Staphylopine dehydrogenase in complex with staphylopine and NADP+ | 分子名称: | (2~{S})-4-[[(2~{R})-3-(1~{H}-imidazol-4-yl)-1-oxidanyl-1-oxidanylidene-propan-2-yl]amino]-2-[[(2~{S})-1-oxidanyl-1-oxidanylidene-propan-2-yl]amino]butanoic acid, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Hajjar, C, Arnoux, P. | 登録日 | 2018-07-18 | 公開日 | 2019-04-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Control by Metals of Staphylopine Dehydrogenase Activity during Metallophore Biosynthesis. J.Am.Chem.Soc., 141, 2019
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1AFC
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![BU of 1afc by Molmil](/molmil-images/mine/1afc) | STRUCTURAL STUDIES OF THE BINDING OF THE ANTI-ULCER DRUG SUCROSE OCTASULFATE TO ACIDIC FIBROBLAST GROWTH FACTOR | 分子名称: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, ACIDIC FIBROBLAST GROWTH FACTOR | 著者 | Zhu, X, Hsu, B.T, Rees, D.C. | 登録日 | 1993-07-13 | 公開日 | 1993-10-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural studies of the binding of the anti-ulcer drug sucrose octasulfate to acidic fibroblast growth factor. Structure, 1, 1993
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6H3D
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![BU of 6h3d by Molmil](/molmil-images/mine/6h3d) | Staphylopine dehydrogenase in complex with xNA | 分子名称: | D-HISTIDINE, DUF2338 domain-containing protein, GLYCEROL, ... | 著者 | Hajjar, C, Arnoux, P. | 登録日 | 2018-07-18 | 公開日 | 2019-04-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Control by Metals of Staphylopine Dehydrogenase Activity during Metallophore Biosynthesis. J.Am.Chem.Soc., 141, 2019
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7VFW
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![BU of 7vfw by Molmil](/molmil-images/mine/7vfw) | Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to CaV2.2-blocker1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazole, CALCIUM ION, ... | 著者 | Dong, Y, Gao, Y, Wang, Y, Zhao, Y. | 登録日 | 2021-09-13 | 公開日 | 2021-11-03 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Closed-state inactivation and pore-blocker modulation mechanisms of human Ca V 2.2. Cell Rep, 37, 2021
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6DNA
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![BU of 6dna by Molmil](/molmil-images/mine/6dna) | Crystal structure of T110A mutant human Glutamate oxaloacetate transaminase 1 (GOT1) | 分子名称: | Aspartate aminotransferase, cytoplasmic, PYRIDOXAL-5'-PHOSPHATE, ... | 著者 | Assar, Z, Holt, M.C, Stein, A.J, Lairson, L, Lyssiotis, C.A. | 登録日 | 2018-06-06 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry, 57, 2018
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6D46
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6D5A
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![BU of 6d5a by Molmil](/molmil-images/mine/6d5a) | |
1XSB
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![BU of 1xsb by Molmil](/molmil-images/mine/1xsb) | Structure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) in complex with ATP. No ATP restraints included | 分子名称: | Bis(5'-nucleosyl)-tetraphosphatase | 著者 | Swarbrick, J.D, Buyya, S, Gunawardana, D, Gayler, K.R, McLennan, A.G, Gooley, P.R. | 登録日 | 2004-10-18 | 公開日 | 2004-12-21 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and Substrate-binding Mechanism of Human Ap4A Hydrolase J.Biol.Chem., 280, 2005
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7XQW
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![BU of 7xqw by Molmil](/molmil-images/mine/7xqw) | Formate dehydrogenase (FDH) from Methylobacterium extorquens AM1 (MeFDH1) | 分子名称: | 2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... | 著者 | Park, J, Heo, Y.Y, Roh, S.H, Lee, H.H. | 登録日 | 2022-05-09 | 公開日 | 2023-08-09 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Enzymatic conversion of CO2 in real flue gas to molar-scale formate To Be Published
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7Y61
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![BU of 7y61 by Molmil](/molmil-images/mine/7y61) | Cryo-EM structure of the two CAF1LCs bound right-handed Di-tetrasome | 分子名称: | Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ... | 著者 | Liu, C.P, Yu, Z.Y, Yu, C, Xu, R.M. | 登録日 | 2022-06-18 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | 主引用文献 | Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023
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7Y5W
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![BU of 7y5w by Molmil](/molmil-images/mine/7y5w) | Cryo-EM structure of the left-handed Di-tetrasome | 分子名称: | Histone H3.1, Histone H4, Widom 601 DNA (147-MER) | 著者 | Liu, C.P, Yu, Z.Y, Yu, C, Xu, R.M. | 登録日 | 2022-06-17 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023
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7Y60
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![BU of 7y60 by Molmil](/molmil-images/mine/7y60) | Cryo-EM structure of human CAF1LC bound right-handed Di-tetrasome | 分子名称: | Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ... | 著者 | Liu, C.P, Yu, C, Yu, Z.Y, Xu, R.M. | 登録日 | 2022-06-18 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023
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6DCX
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6DND
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![BU of 6dnd by Molmil](/molmil-images/mine/6dnd) | Crystal structure of wild-type (WT) human Glutamate oxaloacetate transaminase 1 (GOT1) | 分子名称: | Aspartate aminotransferase, cytoplasmic, PYRIDOXAL-5'-PHOSPHATE, ... | 著者 | Assar, Z, Holt, M.C, Stein, A.J, Lairson, L, Lyssiotis, C.A. | 登録日 | 2018-06-06 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry, 57, 2018
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1VAQ
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![BU of 1vaq by Molmil](/molmil-images/mine/1vaq) | Crystal structure of the Mg2+-(chromomycin A3)2-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by metal ion | 分子名称: | (1S)-5-deoxy-1-O-methyl-1-C-[(2R,3S)-3,5,7,10-tetrahydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl]-D-xylulose, 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose-(1-3)-(2R,3R,6R)-6-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate, 3-C-methyl-4-O-acetyl-alpha-L-Olivopyranose-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol, ... | 著者 | Hou, M.H, Robinson, H, Gao, Y.G, Wang, A.H.-J. | 登録日 | 2004-02-19 | 公開日 | 2004-06-22 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of the [Mg2+-(chromomycin A3)2]-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by a metal ion Nucleic Acids Res., 32, 2004
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7XQ0
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![BU of 7xq0 by Molmil](/molmil-images/mine/7xq0) | Structure of hSLC19A1+3'3'-CDA | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Reduced folate transporter | 著者 | Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P. | 登録日 | 2022-05-06 | 公開日 | 2022-10-05 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Recognition of cyclic dinucleotides and folates by human SLC19A1. Nature, 612, 2022
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2Q0G
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6DNB
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![BU of 6dnb by Molmil](/molmil-images/mine/6dnb) | Crystal structure of T110A:S256A mutant human Glutamate oxaloacetate transaminase 1 (GOT1) | 分子名称: | Aspartate aminotransferase, cytoplasmic, GLYCEROL, ... | 著者 | Assar, Z, Holt, M.C, Stein, A.J, Lairson, L, Lyssiotis, C.A. | 登録日 | 2018-06-06 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry, 57, 2018
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6DUE
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![BU of 6due by Molmil](/molmil-images/mine/6due) | Toxoplasma gondii MyoA, a Class-XIV myosin, in the pre-powerstroke state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | 著者 | Powell, C.J, Boulanger, M.J. | 登録日 | 2018-06-20 | 公開日 | 2018-10-31 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA fromToxoplasma gondii. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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3C9N
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![BU of 3c9n by Molmil](/molmil-images/mine/3c9n) | Crystal Structure of a SARS Corona Virus Derived Peptide Bound to the Human Major Histocompatibility Complex Class I molecule HLA-B*1501 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | 著者 | Roder, G.A, Kristensen, O, Kastrup, J.S, Buus, S, Gajhede, M. | 登録日 | 2008-02-18 | 公開日 | 2008-02-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501. ACTA CRYSTALLOGR.,SECT.F, 64, 2008
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1Z3W
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![BU of 1z3w by Molmil](/molmil-images/mine/1z3w) | Structure of Phanerochaete chrysosporium cellobiohydrolase Cel7D (CBH58) in complex with cellobioimidazole | 分子名称: | (5R,6R,7R,8S)-7,8-dihydroxy-5-(hydroxymethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-6-yl beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, cellulase | 著者 | Ubhayasekera, W, Vasella, A, Stahlberg, J, Mowbray, S.L. | 登録日 | 2005-03-14 | 公開日 | 2005-04-26 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structures of Phanerochaete chrysosporium Cel7D in complex with product and inhibitors Febs J., 272, 2005
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7Z0E
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![BU of 7z0e by Molmil](/molmil-images/mine/7z0e) | Crystal structure of the M state of bacteriorhodopsin at 1.22 Angstrom resolution | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene, 2,3-DI-PHYTANYL-GLYCEROL, ... | 著者 | Borshchevskiy, V, Kovalev, K, Round, E, Efremov, R, Bourenkov, G, Gordeliy, V. | 登録日 | 2022-02-22 | 公開日 | 2022-05-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.22 Å) | 主引用文献 | True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins. Nat.Struct.Mol.Biol., 29, 2022
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2ZJJ
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7Z5O
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![BU of 7z5o by Molmil](/molmil-images/mine/7z5o) | W-formate dehydrogenase from Desulfovibrio vulgaris - Dithionite reduced form | 分子名称: | 2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE, DI(HYDROXYETHYL)ETHER, Formate dehydrogenase, ... | 著者 | Mota, C, Oliveira, A.R, Klymanska, K, Pereira, I.C, Romao, M.J. | 登録日 | 2022-03-09 | 公開日 | 2022-07-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.527 Å) | 主引用文献 | Spectroscopic and Structural Characterization of Reduced Desulfovibrio vulgaris Hildenborough W-FdhAB Reveals Stable Metal Coordination during Catalysis. Acs Chem.Biol., 17, 2022
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