1AFC

STRUCTURAL STUDIES OF THE BINDING OF THE ANTI-ULCER DRUG SUCROSE OCTASULFATE TO ACIDIC FIBROBLAST GROWTH FACTOR

Summary for 1AFC

Entry DOI	10.2210/pdb1afc/pdb
Related PRD ID	PRD_900013
Descriptor	ACIDIC FIBROBLAST GROWTH FACTOR, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose (2 entities in total)
Functional Keywords	growth factor
Biological source	Bos taurus (cattle)
Total number of polymer chains	8
Total formula weight	134830.48
Authors	Zhu, X.,Hsu, B.T.,Rees, D.C. (deposition date: 1993-07-13, release date: 1993-10-31, Last modification date: 2024-02-07)
Primary citation	Zhu, X.,Hsu, B.T.,Rees, D.C. Structural studies of the binding of the anti-ulcer drug sucrose octasulfate to acidic fibroblast growth factor. Structure, 1:27-34, 1993 Cited by PubMed Abstract: The anti-ulcer drug sucrose octasulfate (SOS) binds to fibroblast growth factors (FGFs), proteins which stimulate the growth and differentiation of several cell types, including stomach epithelial cells. It is believed that SOS stabilizes FGFs against acid denaturation in the stomach, thus enhancing their ability to stimulate healing of ulcerated tissue. SOS binds to the same site on FGF as heparin and other proteoglycans; in vivo, FGF must bind to cell-surface proteoglycans or to heparin before it can interact with FGF receptors and stimulate growth. The details of this process are not understood. PubMed: 7520817 DOI: 10.1016/0969-2126(93)90006-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation