1AFC

STRUCTURAL STUDIES OF THE BINDING OF THE ANTI-ULCER DRUG SUCROSE OCTASULFATE TO ACIDIC FIBROBLAST GROWTH FACTOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001525	biological_process	angiogenesis
A	0005104	molecular_function	fibroblast growth factor receptor binding
A	0005178	molecular_function	integrin binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005938	cellular_component	cell cortex
A	0008083	molecular_function	growth factor activity
A	0008201	molecular_function	heparin binding
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008543	biological_process	fibroblast growth factor receptor signaling pathway
A	0009887	biological_process	animal organ morphogenesis
A	0010595	biological_process	positive regulation of endothelial cell migration
A	0010628	biological_process	positive regulation of gene expression
A	0030154	biological_process	cell differentiation
A	0030334	biological_process	regulation of cell migration
A	0030335	biological_process	positive regulation of cell migration
A	0032148	biological_process	activation of protein kinase B activity
A	0034605	biological_process	cellular response to heat
A	0044548	molecular_function	S100 protein binding
A	0045542	biological_process	positive regulation of cholesterol biosynthetic process
A	0045766	biological_process	positive regulation of angiogenesis
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0051781	biological_process	positive regulation of cell division
A	0060681	biological_process	branch elongation involved in ureteric bud branching
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0072163	biological_process	mesonephric epithelium development
A	1901509	biological_process	regulation of endothelial tube morphogenesis
A	1902533	biological_process	positive regulation of intracellular signal transduction
A	1903672	biological_process	positive regulation of sprouting angiogenesis
B	0001525	biological_process	angiogenesis
B	0005104	molecular_function	fibroblast growth factor receptor binding
B	0005178	molecular_function	integrin binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005938	cellular_component	cell cortex
B	0008083	molecular_function	growth factor activity
B	0008201	molecular_function	heparin binding
B	0008284	biological_process	positive regulation of cell population proliferation
B	0008543	biological_process	fibroblast growth factor receptor signaling pathway
B	0009887	biological_process	animal organ morphogenesis
B	0010595	biological_process	positive regulation of endothelial cell migration
B	0010628	biological_process	positive regulation of gene expression
B	0030154	biological_process	cell differentiation
B	0030334	biological_process	regulation of cell migration
B	0030335	biological_process	positive regulation of cell migration
B	0032148	biological_process	activation of protein kinase B activity
B	0034605	biological_process	cellular response to heat
B	0044548	molecular_function	S100 protein binding
B	0045542	biological_process	positive regulation of cholesterol biosynthetic process
B	0045766	biological_process	positive regulation of angiogenesis
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0051781	biological_process	positive regulation of cell division
B	0060681	biological_process	branch elongation involved in ureteric bud branching
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	0072163	biological_process	mesonephric epithelium development
B	1901509	biological_process	regulation of endothelial tube morphogenesis
B	1902533	biological_process	positive regulation of intracellular signal transduction
B	1903672	biological_process	positive regulation of sprouting angiogenesis
C	0001525	biological_process	angiogenesis
C	0005104	molecular_function	fibroblast growth factor receptor binding
C	0005178	molecular_function	integrin binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005938	cellular_component	cell cortex
C	0008083	molecular_function	growth factor activity
C	0008201	molecular_function	heparin binding
C	0008284	biological_process	positive regulation of cell population proliferation
C	0008543	biological_process	fibroblast growth factor receptor signaling pathway
C	0009887	biological_process	animal organ morphogenesis
C	0010595	biological_process	positive regulation of endothelial cell migration
C	0010628	biological_process	positive regulation of gene expression
C	0030154	biological_process	cell differentiation
C	0030334	biological_process	regulation of cell migration
C	0030335	biological_process	positive regulation of cell migration
C	0032148	biological_process	activation of protein kinase B activity
C	0034605	biological_process	cellular response to heat
C	0044548	molecular_function	S100 protein binding
C	0045542	biological_process	positive regulation of cholesterol biosynthetic process
C	0045766	biological_process	positive regulation of angiogenesis
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0051781	biological_process	positive regulation of cell division
C	0060681	biological_process	branch elongation involved in ureteric bud branching
C	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
C	0072163	biological_process	mesonephric epithelium development
C	1901509	biological_process	regulation of endothelial tube morphogenesis
C	1902533	biological_process	positive regulation of intracellular signal transduction
C	1903672	biological_process	positive regulation of sprouting angiogenesis
D	0001525	biological_process	angiogenesis
D	0005104	molecular_function	fibroblast growth factor receptor binding
D	0005178	molecular_function	integrin binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005938	cellular_component	cell cortex
D	0008083	molecular_function	growth factor activity
D	0008201	molecular_function	heparin binding
D	0008284	biological_process	positive regulation of cell population proliferation
D	0008543	biological_process	fibroblast growth factor receptor signaling pathway
D	0009887	biological_process	animal organ morphogenesis
D	0010595	biological_process	positive regulation of endothelial cell migration
D	0010628	biological_process	positive regulation of gene expression
D	0030154	biological_process	cell differentiation
D	0030334	biological_process	regulation of cell migration
D	0030335	biological_process	positive regulation of cell migration
D	0032148	biological_process	activation of protein kinase B activity
D	0034605	biological_process	cellular response to heat
D	0044548	molecular_function	S100 protein binding
D	0045542	biological_process	positive regulation of cholesterol biosynthetic process
D	0045766	biological_process	positive regulation of angiogenesis
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0051781	biological_process	positive regulation of cell division
D	0060681	biological_process	branch elongation involved in ureteric bud branching
D	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
D	0072163	biological_process	mesonephric epithelium development
D	1901509	biological_process	regulation of endothelial tube morphogenesis
D	1902533	biological_process	positive regulation of intracellular signal transduction
D	1903672	biological_process	positive regulation of sprouting angiogenesis
E	0001525	biological_process	angiogenesis
E	0005104	molecular_function	fibroblast growth factor receptor binding
E	0005178	molecular_function	integrin binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005938	cellular_component	cell cortex
E	0008083	molecular_function	growth factor activity
E	0008201	molecular_function	heparin binding
E	0008284	biological_process	positive regulation of cell population proliferation
E	0008543	biological_process	fibroblast growth factor receptor signaling pathway
E	0009887	biological_process	animal organ morphogenesis
E	0010595	biological_process	positive regulation of endothelial cell migration
E	0010628	biological_process	positive regulation of gene expression
E	0030154	biological_process	cell differentiation
E	0030334	biological_process	regulation of cell migration
E	0030335	biological_process	positive regulation of cell migration
E	0032148	biological_process	activation of protein kinase B activity
E	0034605	biological_process	cellular response to heat
E	0044548	molecular_function	S100 protein binding
E	0045542	biological_process	positive regulation of cholesterol biosynthetic process
E	0045766	biological_process	positive regulation of angiogenesis
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0051781	biological_process	positive regulation of cell division
E	0060681	biological_process	branch elongation involved in ureteric bud branching
E	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
E	0072163	biological_process	mesonephric epithelium development
E	1901509	biological_process	regulation of endothelial tube morphogenesis
E	1902533	biological_process	positive regulation of intracellular signal transduction
E	1903672	biological_process	positive regulation of sprouting angiogenesis
F	0001525	biological_process	angiogenesis
F	0005104	molecular_function	fibroblast growth factor receptor binding
F	0005178	molecular_function	integrin binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005938	cellular_component	cell cortex
F	0008083	molecular_function	growth factor activity
F	0008201	molecular_function	heparin binding
F	0008284	biological_process	positive regulation of cell population proliferation
F	0008543	biological_process	fibroblast growth factor receptor signaling pathway
F	0009887	biological_process	animal organ morphogenesis
F	0010595	biological_process	positive regulation of endothelial cell migration
F	0010628	biological_process	positive regulation of gene expression
F	0030154	biological_process	cell differentiation
F	0030334	biological_process	regulation of cell migration
F	0030335	biological_process	positive regulation of cell migration
F	0032148	biological_process	activation of protein kinase B activity
F	0034605	biological_process	cellular response to heat
F	0044548	molecular_function	S100 protein binding
F	0045542	biological_process	positive regulation of cholesterol biosynthetic process
F	0045766	biological_process	positive regulation of angiogenesis
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0051781	biological_process	positive regulation of cell division
F	0060681	biological_process	branch elongation involved in ureteric bud branching
F	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
F	0072163	biological_process	mesonephric epithelium development
F	1901509	biological_process	regulation of endothelial tube morphogenesis
F	1902533	biological_process	positive regulation of intracellular signal transduction
F	1903672	biological_process	positive regulation of sprouting angiogenesis
G	0001525	biological_process	angiogenesis
G	0005104	molecular_function	fibroblast growth factor receptor binding
G	0005178	molecular_function	integrin binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005938	cellular_component	cell cortex
G	0008083	molecular_function	growth factor activity
G	0008201	molecular_function	heparin binding
G	0008284	biological_process	positive regulation of cell population proliferation
G	0008543	biological_process	fibroblast growth factor receptor signaling pathway
G	0009887	biological_process	animal organ morphogenesis
G	0010595	biological_process	positive regulation of endothelial cell migration
G	0010628	biological_process	positive regulation of gene expression
G	0030154	biological_process	cell differentiation
G	0030334	biological_process	regulation of cell migration
G	0030335	biological_process	positive regulation of cell migration
G	0032148	biological_process	activation of protein kinase B activity
G	0034605	biological_process	cellular response to heat
G	0044548	molecular_function	S100 protein binding
G	0045542	biological_process	positive regulation of cholesterol biosynthetic process
G	0045766	biological_process	positive regulation of angiogenesis
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0051781	biological_process	positive regulation of cell division
G	0060681	biological_process	branch elongation involved in ureteric bud branching
G	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
G	0072163	biological_process	mesonephric epithelium development
G	1901509	biological_process	regulation of endothelial tube morphogenesis
G	1902533	biological_process	positive regulation of intracellular signal transduction
G	1903672	biological_process	positive regulation of sprouting angiogenesis
H	0001525	biological_process	angiogenesis
H	0005104	molecular_function	fibroblast growth factor receptor binding
H	0005178	molecular_function	integrin binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005938	cellular_component	cell cortex
H	0008083	molecular_function	growth factor activity
H	0008201	molecular_function	heparin binding
H	0008284	biological_process	positive regulation of cell population proliferation
H	0008543	biological_process	fibroblast growth factor receptor signaling pathway
H	0009887	biological_process	animal organ morphogenesis
H	0010595	biological_process	positive regulation of endothelial cell migration
H	0010628	biological_process	positive regulation of gene expression
H	0030154	biological_process	cell differentiation
H	0030334	biological_process	regulation of cell migration
H	0030335	biological_process	positive regulation of cell migration
H	0032148	biological_process	activation of protein kinase B activity
H	0034605	biological_process	cellular response to heat
H	0044548	molecular_function	S100 protein binding
H	0045542	biological_process	positive regulation of cholesterol biosynthetic process
H	0045766	biological_process	positive regulation of angiogenesis
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0051781	biological_process	positive regulation of cell division
H	0060681	biological_process	branch elongation involved in ureteric bud branching
H	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
H	0072163	biological_process	mesonephric epithelium development
H	1901509	biological_process	regulation of endothelial tube morphogenesis
H	1902533	biological_process	positive regulation of intracellular signal transduction
H	1903672	biological_process	positive regulation of sprouting angiogenesis

Functional Information from PROSITE/UniProt

site_id	PS00247
Number of Residues	24
Details	HBGF_FGF HBGF/FGF family signature. GlLyGsqtpne.EClFlErleenhY

Chain	Residue	Details
A	GLY71-TYR94

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
A	LYS9
E	ILE98
F	LYS9
F	ILE98
G	LYS9
G	ILE98
H	LYS9
H	ILE98
A	ILE98
B	LYS9
B	ILE98
C	LYS9
C	ILE98
D	LYS9
D	ILE98
E	LYS9

---