6DNA
Crystal structure of T110A mutant human Glutamate oxaloacetate transaminase 1 (GOT1)
Summary for 6DNA
Entry DOI | 10.2210/pdb6dna/pdb |
Descriptor | Aspartate aminotransferase, cytoplasmic, TETRAETHYLENE GLYCOL, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total) |
Functional Keywords | aspartate aminotransferase, glutamate oxaloacetate transaminase 1, got1, plp, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 6 |
Total formula weight | 276779.75 |
Authors | Assar, Z.,Holt, M.C.,Stein, A.J.,Lairson, L.,Lyssiotis, C.A. (deposition date: 2018-06-06, release date: 2018-11-14, Last modification date: 2023-10-11) |
Primary citation | Holt, M.C.,Assar, Z.,Beheshti Zavareh, R.,Lin, L.,Anglin, J.,Mashadova, O.,Haldar, D.,Mullarky, E.,Kremer, D.M.,Cantley, L.C.,Kimmelman, A.C.,Stein, A.J.,Lairson, L.L.,Lyssiotis, C.A. Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry, 57:6604-6614, 2018 Cited by PubMed: 30365304DOI: 10.1021/acs.biochem.8b00914 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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