Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6DNA

Crystal structure of T110A mutant human Glutamate oxaloacetate transaminase 1 (GOT1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004069	molecular_function	L-aspartate:2-oxoglutarate aminotransferase activity
A	0004609	molecular_function	phosphatidylserine decarboxylase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006103	biological_process	2-oxoglutarate metabolic process
A	0006107	biological_process	oxaloacetate metabolic process
A	0006114	biological_process	glycerol biosynthetic process
A	0006520	biological_process	amino acid metabolic process
A	0006531	biological_process	aspartate metabolic process
A	0006532	biological_process	aspartate biosynthetic process
A	0006533	biological_process	aspartate catabolic process
A	0006536	biological_process	glutamate metabolic process
A	0007219	biological_process	Notch signaling pathway
A	0008483	molecular_function	transaminase activity
A	0008652	biological_process	amino acid biosynthetic process
A	0009058	biological_process	biosynthetic process
A	0019550	biological_process	glutamate catabolic process to aspartate
A	0019551	biological_process	glutamate catabolic process to 2-oxoglutarate
A	0030170	molecular_function	pyridoxal phosphate binding
A	0032869	biological_process	cellular response to insulin stimulus
A	0047801	molecular_function	L-cysteine transaminase activity
A	0051384	biological_process	response to glucocorticoid
A	0055089	biological_process	fatty acid homeostasis
A	0070062	cellular_component	extracellular exosome
B	0003824	molecular_function	catalytic activity
B	0004069	molecular_function	L-aspartate:2-oxoglutarate aminotransferase activity
B	0004609	molecular_function	phosphatidylserine decarboxylase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006094	biological_process	gluconeogenesis
B	0006103	biological_process	2-oxoglutarate metabolic process
B	0006107	biological_process	oxaloacetate metabolic process
B	0006114	biological_process	glycerol biosynthetic process
B	0006520	biological_process	amino acid metabolic process
B	0006531	biological_process	aspartate metabolic process
B	0006532	biological_process	aspartate biosynthetic process
B	0006533	biological_process	aspartate catabolic process
B	0006536	biological_process	glutamate metabolic process
B	0007219	biological_process	Notch signaling pathway
B	0008483	molecular_function	transaminase activity
B	0008652	biological_process	amino acid biosynthetic process
B	0009058	biological_process	biosynthetic process
B	0019550	biological_process	glutamate catabolic process to aspartate
B	0019551	biological_process	glutamate catabolic process to 2-oxoglutarate
B	0030170	molecular_function	pyridoxal phosphate binding
B	0032869	biological_process	cellular response to insulin stimulus
B	0047801	molecular_function	L-cysteine transaminase activity
B	0051384	biological_process	response to glucocorticoid
B	0055089	biological_process	fatty acid homeostasis
B	0070062	cellular_component	extracellular exosome
C	0003824	molecular_function	catalytic activity
C	0004069	molecular_function	L-aspartate:2-oxoglutarate aminotransferase activity
C	0004609	molecular_function	phosphatidylserine decarboxylase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006094	biological_process	gluconeogenesis
C	0006103	biological_process	2-oxoglutarate metabolic process
C	0006107	biological_process	oxaloacetate metabolic process
C	0006114	biological_process	glycerol biosynthetic process
C	0006520	biological_process	amino acid metabolic process
C	0006531	biological_process	aspartate metabolic process
C	0006532	biological_process	aspartate biosynthetic process
C	0006533	biological_process	aspartate catabolic process
C	0006536	biological_process	glutamate metabolic process
C	0007219	biological_process	Notch signaling pathway
C	0008483	molecular_function	transaminase activity
C	0008652	biological_process	amino acid biosynthetic process
C	0009058	biological_process	biosynthetic process
C	0019550	biological_process	glutamate catabolic process to aspartate
C	0019551	biological_process	glutamate catabolic process to 2-oxoglutarate
C	0030170	molecular_function	pyridoxal phosphate binding
C	0032869	biological_process	cellular response to insulin stimulus
C	0047801	molecular_function	L-cysteine transaminase activity
C	0051384	biological_process	response to glucocorticoid
C	0055089	biological_process	fatty acid homeostasis
C	0070062	cellular_component	extracellular exosome
D	0003824	molecular_function	catalytic activity
D	0004069	molecular_function	L-aspartate:2-oxoglutarate aminotransferase activity
D	0004609	molecular_function	phosphatidylserine decarboxylase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006094	biological_process	gluconeogenesis
D	0006103	biological_process	2-oxoglutarate metabolic process
D	0006107	biological_process	oxaloacetate metabolic process
D	0006114	biological_process	glycerol biosynthetic process
D	0006520	biological_process	amino acid metabolic process
D	0006531	biological_process	aspartate metabolic process
D	0006532	biological_process	aspartate biosynthetic process
D	0006533	biological_process	aspartate catabolic process
D	0006536	biological_process	glutamate metabolic process
D	0007219	biological_process	Notch signaling pathway
D	0008483	molecular_function	transaminase activity
D	0008652	biological_process	amino acid biosynthetic process
D	0009058	biological_process	biosynthetic process
D	0019550	biological_process	glutamate catabolic process to aspartate
D	0019551	biological_process	glutamate catabolic process to 2-oxoglutarate
D	0030170	molecular_function	pyridoxal phosphate binding
D	0032869	biological_process	cellular response to insulin stimulus
D	0047801	molecular_function	L-cysteine transaminase activity
D	0051384	biological_process	response to glucocorticoid
D	0055089	biological_process	fatty acid homeostasis
D	0070062	cellular_component	extracellular exosome
E	0003824	molecular_function	catalytic activity
E	0004069	molecular_function	L-aspartate:2-oxoglutarate aminotransferase activity
E	0004609	molecular_function	phosphatidylserine decarboxylase activity
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006094	biological_process	gluconeogenesis
E	0006103	biological_process	2-oxoglutarate metabolic process
E	0006107	biological_process	oxaloacetate metabolic process
E	0006114	biological_process	glycerol biosynthetic process
E	0006520	biological_process	amino acid metabolic process
E	0006531	biological_process	aspartate metabolic process
E	0006532	biological_process	aspartate biosynthetic process
E	0006533	biological_process	aspartate catabolic process
E	0006536	biological_process	glutamate metabolic process
E	0007219	biological_process	Notch signaling pathway
E	0008483	molecular_function	transaminase activity
E	0008652	biological_process	amino acid biosynthetic process
E	0009058	biological_process	biosynthetic process
E	0019550	biological_process	glutamate catabolic process to aspartate
E	0019551	biological_process	glutamate catabolic process to 2-oxoglutarate
E	0030170	molecular_function	pyridoxal phosphate binding
E	0032869	biological_process	cellular response to insulin stimulus
E	0047801	molecular_function	L-cysteine transaminase activity
E	0051384	biological_process	response to glucocorticoid
E	0055089	biological_process	fatty acid homeostasis
E	0070062	cellular_component	extracellular exosome
F	0003824	molecular_function	catalytic activity
F	0004069	molecular_function	L-aspartate:2-oxoglutarate aminotransferase activity
F	0004609	molecular_function	phosphatidylserine decarboxylase activity
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006094	biological_process	gluconeogenesis
F	0006103	biological_process	2-oxoglutarate metabolic process
F	0006107	biological_process	oxaloacetate metabolic process
F	0006114	biological_process	glycerol biosynthetic process
F	0006520	biological_process	amino acid metabolic process
F	0006531	biological_process	aspartate metabolic process
F	0006532	biological_process	aspartate biosynthetic process
F	0006533	biological_process	aspartate catabolic process
F	0006536	biological_process	glutamate metabolic process
F	0007219	biological_process	Notch signaling pathway
F	0008483	molecular_function	transaminase activity
F	0008652	biological_process	amino acid biosynthetic process
F	0009058	biological_process	biosynthetic process
F	0019550	biological_process	glutamate catabolic process to aspartate
F	0019551	biological_process	glutamate catabolic process to 2-oxoglutarate
F	0030170	molecular_function	pyridoxal phosphate binding
F	0032869	biological_process	cellular response to insulin stimulus
F	0047801	molecular_function	L-cysteine transaminase activity
F	0051384	biological_process	response to glucocorticoid
F	0055089	biological_process	fatty acid homeostasis
F	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue PG4 A 501

Chain	Residue
A	GLU250

site_id	AC2
Number of Residues	11
Details	binding site for residue PLP A 502

Chain	Residue
A	SER258
A	LYS259
A	ARG267
A	GLY108
A	GLY109
A	ALA110
A	TRP141
A	ASN195
A	ASP223
A	ALA225
A	SER256

site_id	AC3
Number of Residues	2
Details	binding site for residue PG4 B 501

Chain	Residue
B	GLU250
B	LYS276

site_id	AC4
Number of Residues	10
Details	binding site for residue PLP B 502

Chain	Residue
B	GLY109
B	TRP141
B	ASN195
B	ASP223
B	ALA225
B	SER256
B	SER258
B	LYS259
B	ARG267
B	HOH601

site_id	AC5
Number of Residues	10
Details	binding site for residue PLP C 501

Chain	Residue
C	GLY109
C	ALA110
C	TRP141
C	ASN195
C	ASP223
C	ALA225
C	SER256
C	SER258
C	LYS259
C	ARG267

site_id	AC6
Number of Residues	3
Details	binding site for residue PG4 D 501

Chain	Residue
D	GLU250
D	GLN283
D	VAL284

site_id	AC7
Number of Residues	11
Details	binding site for residue PLP D 502

Chain	Residue
D	GLY108
D	GLY109
D	ALA110
D	TRP141
D	HIS144
D	ASN195
D	ASP223
D	SER256
D	SER258
D	LYS259
D	ARG267

site_id	AC8
Number of Residues	11
Details	binding site for residue PLP E 501

Chain	Residue
E	GLY108
E	GLY109
E	ALA110
E	TRP141
E	ASN195
E	ASP223
E	ALA225
E	SER256
E	SER258
E	LYS259
E	ARG267

site_id	AC9
Number of Residues	10
Details	binding site for residue PLP F 501

Chain	Residue
F	GLY108
F	GLY109
F	ALA110
F	TRP141
F	ASN195
F	ASP223
F	SER256
F	SER258
F	LYS259
F	ARG267

Functional Information from PROSITE/UniProt

site_id	PS00105
Number of Residues	14
Details	AA_TRANSFER_CLASS_1 Aminotransferases class-I pyridoxal-phosphate attachment site. SFSKnfGLyNERVG

Chain	Residue	Details
A	SER256-GLY269

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING:

Chain	Residue	Details
A	GLY39
C	TRP141
C	ASN195
C	ARG387
D	GLY39
D	TRP141
D	ASN195
D	ARG387
E	GLY39
E	TRP141
E	ASN195
A	TRP141
E	ARG387
F	GLY39
F	TRP141
F	ASN195
F	ARG387
A	ASN195
A	ARG387
B	GLY39
B	TRP141
B	ASN195
B	ARG387
C	GLY39

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P13221

Chain	Residue	Details
A	SER149
B	SER149
C	SER149
D	SER149
E	SER149
F	SER149

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000250

Chain	Residue	Details
A	LYS259
B	LYS259
C	LYS259
D	LYS259
E	LYS259
F	LYS259

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)