PDB: 66507 件ウェブページステータス検索Chemie searchBIRD

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7BGR	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1016 分子名称: 14-3-3 protein sigma, 2-methyl-4-(2-phenylimidazol-1-yl)benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-01-08 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BDP	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1017 分子名称: 14-3-3 protein sigma, 2-chloranyl-4-(2-phenylimidazol-1-yl)benzaldehyde, MAGNESIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2020-12-22 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BDT	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1009 分子名称: 14-3-3 protein sigma, 2-bromanyl-4-(2-phenylimidazol-1-yl)benzaldehyde, MAGNESIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2020-12-22 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BGV	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1012 分子名称: 14-3-3 protein sigma, 3-methoxy-4-(2-phenylimidazol-1-yl)benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-01-08 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.683 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BDY	14-3-3 sigma with Pin1 binding site pS72 and covalently bound PC2068B 分子名称: 14-3-3 protein sigma, 2-bromanyl-4-[2-(5-bromanyl-2-fluoranyl-phenyl)imidazol-1-yl]benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2020-12-22 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BFW	14-3-3 sigma with Pin1 binding site pS72 and covalently bound PC2068A 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-01-05 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BGW	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1011 分子名称: 14-3-3 protein sigma, 4-(2-phenylimidazol-1-yl)naphthalene-1-carbaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-01-08 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BIY	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-175 分子名称: 1-(4-methanoylphenyl)carbonylpiperidine-4-carbonitrile, 14-3-3 protein sigma, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-01-13 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7ZMW	14-3-3s binding to non-natural peptide 2c 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, non-natural peptide 1 著者 Somsen, B.A, Craenmehr, F.W.B, Ottmann, C. 登録日 2022-04-19 公開日 2022-11-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues. Chem Sci, 13, 2022
2H9N	WDR5 in complex with monomethylated H3K4 peptide 分子名称: H3 histone, WD-repeat protein 5 著者 Min, J.R, Schuetz, A, Allali-Hassani, A, Martin, F, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) 登録日 2006-06-10 公開日 2006-08-01 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for molecular recognition and presentation of histone H3 By WDR5. Embo J., 25, 2006
5CN0	Artificial HIV fusion inhibitor AP2 fused to the C-terminus of gp41 NHR 分子名称: DI(HYDROXYETHYL)ETHER, Envelope glycoprotein,AP2, MAGNESIUM ION 著者 Zhu, Y, Ye, S, Zhang, R. 登録日 2015-07-17 公開日 2015-09-16 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.901 Å) 主引用文献 Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy. Sci Rep, 5, 2015
7BEZ	Zinc bound domain 3 of carbonic anhydrase from marine diatom Thalassiosira weissflogii 分子名称: Cadmium-specific carbonic anhydrase, ZINC ION 著者 Alterio, V, De Simone, G. 登録日 2021-01-06 公開日 2021-07-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.981 Å) 主引用文献 Zeta-carbonic anhydrases show CS 2 hydrolase activity: A new metabolic carbon acquisition pathway in diatoms? Comput Struct Biotechnol J, 19, 2021
7B9M	Cys-45-tethered stabilizer 3 of 14-3-3(sigma)/ERa PPI 分子名称: 14-3-3 protein sigma, 2-(2-cyanophenyl)sulfanyl-~{N}-(2-sulfanylethyl)benzamide, Estrogen receptor, ... 著者 Sijbesma, E, Ottmann, C. 登録日 2020-12-14 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
6C2N	Crystal structure of HCV NS3/4A double mutant variant Y56H/D168A in complex with danoprevir 分子名称: (2R,6S,12Z,13aS,14aR,16aS)-6-[(tert-butoxycarbonyl)amino]-14a-[(cyclopropylsulfonyl)carbamoyl]-5,16-dioxo-1,2,3,5,6,7,8 ,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoro-2H-isoindole-2-carboxylate, NS4A COFACTOR-NS3 PROTEIN CHIMERA, SULFATE ION, ... 著者 Matthew, A.N, Schiffer, C.A. 登録日 2018-01-08 公開日 2019-01-16 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.802 Å) 主引用文献 Clinical signature variant of HCV NS3/4A protease uses a novel mechanism to confer resistance To Be Published
4YD1	Ternary complex of human DNA Polymerase Mu with 2-nt gapped DNA substrate and an incoming nonhydrolyzable dUMPNPP 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, ... 著者 Moon, A.F, Gosavi, R.A, Kunkel, T.A, Pedersen, L.C, Bebenek, K. 登録日 2015-02-20 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Creative template-dependent synthesis by human polymerase mu. Proc.Natl.Acad.Sci.USA, 112, 2015
2BC3	T7-tagged full-length streptavidin 分子名称: GLYCEROL, SULFATE ION, Streptavidin 著者 Stenkamp, R.E, Le Trong, I, Ward, T.R, Humbert, N. 登録日 2005-10-18 公開日 2005-10-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Crystallographic Analysis of a Full-length Streptavidin with Its C-terminal Polypeptide Bound in the Biotin Binding Site. J.Mol.Biol., 356, 2006
8A5X	Crystal structure of phosphatidyl inositol 4-kinase II beta in complex with MM1373 分子名称: 4-azanyl-7-[3-(hydroxymethyl)phenyl]quinazoline-6-carboxamide, Phosphatidylinositol 4-kinase type 2-beta,Endolysin 著者 Klima, M, Boura, E. 登録日 2022-06-16 公開日 2022-10-05 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure-based design and modular synthesis of novel PI4K class II inhibitors bearing a 4-aminoquinazoline scaffold. Bioorg.Med.Chem.Lett., 76, 2022
5BOL	DNA polymerase beta ternary complex with a templating 5ClC and incoming dGTP analog 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]guanosine, DNA (5'-D(*CP*CP*GP*AP*CP*(CDO)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... 著者 Freudenthal, B.D, Wilson, S.H. 登録日 2015-05-27 公開日 2015-08-19 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.981 Å) 主引用文献 Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer. Proc.Natl.Acad.Sci.USA, 112, 2015
7BG0	Fusion of MBP and the backbone of the long-acting amylin analog AM833. 分子名称: Maltose/maltodextrin-binding periplasmic protein,Islet amyloid polypeptide, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose 著者 Johansson, E. 登録日 2021-01-05 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Development of Cagrilintide, a Long-Acting Amylin Analogue. J.Med.Chem., 64, 2021
4Y9U	rat CYPOR mutant - G143del 分子名称: FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Xia, C, Kim, J.J.P. 登録日 2015-02-17 公開日 2016-03-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone. J.Biol.Chem., 291, 2016
7BJB	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-044 分子名称: 14-3-3 protein sigma, 4-(4-methylphenyl)sulfonylmorpholine, CALCIUM ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-01-14 公開日 2021-09-15 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
6CJI	Candida albicans Hsp90 nucleotide binding domain 分子名称: 1,2-ETHANEDIOL, Heat shock protein 90 homolog 著者 Hutchinson, A, Loppnau, P, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Hui, R, STRUCTURAL GENOMICS CONSORTIUM, S.G.C, Pizarro, J.C, Structural Genomics Consortium (SGC) 登録日 2018-02-26 公開日 2019-01-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nat Commun, 10, 2019
6CL4	LipC12 - Lipase from metagenomics 分子名称: Lipase C12 著者 Iulek, J, Martini, V.P, Krieger, N, Glogauer, A, Souza, E.M. 登録日 2018-03-01 公開日 2019-03-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.64 Å) 主引用文献 Structure solution and analyses of the first true lipase obtained from metagenomics indicate potential for increased thermostability. N Biotechnol, 53, 2019
6CLW	Crystal structure of TnmH 分子名称: O-methyltransferase 著者 Chang, C.Y, Annaval, T, Adhikari, A, Yan, X, Shen, B. 登録日 2018-03-02 公開日 2019-03-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Characterization of TnmH as anO-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates. J.Med.Chem., 63, 2020
8A2J	human STING in complex with 2'-3'-cyclic-GMP-7-deaza(4-biphenylyl)-AMP 分子名称: 2-azanyl-9-[(1~{R},6~{R},8~{R},9~{R},10~{S},15~{R},17~{R},18~{R})-8-[4-azanyl-5-(4-phenylphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,9,12,18-tetrakis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one, Stimulator of interferon genes protein 著者 Vavrina, Z, Brynda, J, Rezacova, P. 登録日 2022-06-03 公開日 2022-10-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists. J.Med.Chem., 65, 2022

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