6C2N

Crystal structure of HCV NS3/4A double mutant variant Y56H/D168A in complex with danoprevir

Summary for 6C2N

• Entry DOI: 10.2210/pdb6c2n/pdb
• Descriptor: NS4A COFACTOR-NS3 PROTEIN CHIMERA, ZINC ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: ns3/4a protease, hepatitis c virus, drug resistance, protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase
• Biological source: Hepatitis C virus subtype 1a; More
• Total number of polymer chains: 1
• Total formula weight: 22325.58

Authors

Matthew, A.N.,Schiffer, C.A. (deposition date: 2018-01-08, release date: 2019-01-16, Last modification date: 2023-10-04)

• Primary citation: Matthew, A.N.,Schiffer, C.A.; Clinical signature variant of HCV NS3/4A protease uses a novel mechanism to confer resistance; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.802 Å)