PDB: 10243 件ウェブページステータス検索Chemie searchBIRD

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7UBK	Transcription antitermination factor Qlambda, type-II crystal 分子名称: 1,2-ETHANEDIOL, Antitermination protein Q, CHLORIDE ION, ... 著者 Yin, Z, Ebright, R.H. 登録日 2022-03-15 公開日 2022-09-28 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 In transcription antitermination by Q lambda , NusA induces refolding of Q lambda to form a nozzle that extends the RNA polymerase RNA-exit channel. Proc.Natl.Acad.Sci.USA, 119, 2022
3VNV	Complex structure of viral RNA polymerase II 分子名称: 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, Elongation factor Ts, ... 著者 Takeshita, D, Tomita, K. 登録日 2012-01-18 公開日 2012-08-08 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.604 Å) 主引用文献 Mechanism for template-independent terminal adenylation activity of Q beta replicase Structure, 20, 2012
5C2Y	Crystal structure of the Saccharomyces cerevisiae Rtr1 (regulator of transcription) 分子名称: GLYCEROL, RNA polymerase II subunit B1 CTD phosphatase RTR1, SULFATE ION, ... 著者 Yogesha, S.D, Irani, S, Zhang, Y.J. 登録日 2015-06-16 公開日 2016-05-04 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase. Sci.Signal., 9, 2016
3PGL	Crystal structure of human small C-terminal domain phosphatase 1 (Scp1) bound to rabeprazole 分子名称: 2-[(R)-{[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl]-1H-benzimidazole, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, MAGNESIUM ION 著者 Zhang, M, Cho, E.J, Burstein, G, Siegel, D, Zhang, Y. 登録日 2010-11-02 公開日 2011-03-09 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Selective inactivation of a human neuronal silencing phosphatase by a small molecule inhibitor. Acs Chem.Biol., 6, 2011
6P1S	Post-catalytic nicked complex of human DNA Polymerase Mu with 1-nt gapped substrate containing template 8OG and newly incorporated AMP 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Kaminski, A.M, Pedersen, L.C, Bebenek, K, Chiruvella, K.K, Ramsden, D.A, Kunkel, T.A. 登録日 2019-05-20 公開日 2019-09-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine. Nucleic Acids Res., 47, 2019
7PLR	Crystal structure of the N-terminal endonuclease domain of La Crosse virus L-protein bound to compound Baloxavir 分子名称: Baloxavir acid, FORMIC ACID, GLYCEROL, ... 著者 Feracci, M, Hernandez, S, Vincentelli, R, Ferron, F, Reguera, J, Canard, B, Alvarez, K. 登録日 2021-09-01 公開日 2022-09-14 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.64 Å) 主引用文献 Biophysical and structural study of La Crosse virus endonuclease inhibition for the development of new antiviral options. Iucrj, 11, 2024
6P1U	Post-catalytic nicked complex of human DNA Polymerase Mu with 1-nt gapped substrate containing template 8OG and newly incorporated CMP 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... 著者 Kaminski, A.M, Pedersen, L.C, Bebenek, K, Chiruvella, K.K, Ramsden, D.A, Kunkel, T.A. 登録日 2019-05-20 公開日 2019-09-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine. Nucleic Acids Res., 47, 2019
8G1U	Structure of the methylosome-Lsm10/11 complex 分子名称: ADENOSINE, Methylosome protein 50, Methylosome subunit pICln, ... 著者 Lin, M, Paige, A, Tong, L. 登録日 2023-02-03 公開日 2023-08-23 最終更新日 2025-05-28 実験手法 ELECTRON MICROSCOPY (2.83 Å) 主引用文献 In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome. Rna, 29, 2023
3W5Q	Crystal structure of complexes of vitamin D receptor ligand binding domain with lithocholic acid derivatives 分子名称: (5beta,9beta)-3-oxocholan-24-oic acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor 著者 Masuno, H, Ikura, T, Ito, N. 登録日 2013-02-05 公開日 2013-06-26 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives. J.Lipid Res., 54, 2013
3W5R	Crystal structure of complexes of vitamin D receptor ligand binding domain with lithocholic acid derivatives 分子名称: (3beta,5beta,9beta)-3-(acetyloxy)cholan-24-oic acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor 著者 Masuno, H, Ikura, T, Ito, N. 登録日 2013-02-06 公開日 2013-06-26 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives. J.Lipid Res., 54, 2013
3W5P	Crystal structure of complexes of vitamin D receptor ligand binding domain with lithocholic acid derivatives 分子名称: (3beta,5beta,14beta,17alpha)-3-hydroxycholan-24-oic acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor 著者 Masuno, H, Ikura, T, Ito, N. 登録日 2013-02-05 公開日 2013-06-26 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives. J.Lipid Res., 54, 2013
3W5T	Crystal structure of complexes of vitamin D receptor ligand binding domain with lithocholic acid derivatives 分子名称: (3beta,5beta,9beta)-3-(propanoyloxy)cholan-24-oic acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor 著者 Masuno, H, Ikura, T, Ito, N. 登録日 2013-02-06 公開日 2013-06-26 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives. J.Lipid Res., 54, 2013
8PPT	Pyrococcus abyssi DNA polymerase D (PolD) in its editing mode bound to a primer/template substrate containing a mismatch 分子名称: DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA (5'-D(P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*GP*CP*TP*TP*T)-3'), DNA polymerase II small subunit, ... 著者 Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. 登録日 2023-07-10 公開日 2023-12-20 最終更新日 2025-07-02 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases. Nat Commun, 14, 2023
8PPV	Intermediate conformer of Pyrococcus abyssi DNA polymerase D (PolD) bound to a primer/template substrate containing three consecutive mismatches 分子名称: DNA (5'-D(*P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*(GS)P*(G7P)P*(PST)P*(PST)P*(PST))-3'), DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA polymerase II small subunit, ... 著者 Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. 登録日 2023-07-10 公開日 2023-12-20 最終更新日 2025-07-02 実験手法 ELECTRON MICROSCOPY (3.02 Å) 主引用文献 Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases. Nat Commun, 14, 2023
4RQF	human Seryl-tRNA synthetase dimer complexed with one molecule of tRNAsec 分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SERINE, Serine--tRNA ligase, ... 著者 Xie, W, Wang, C, Guo, Y, Tian, Q, Jia, Q. 登録日 2014-11-03 公開日 2015-11-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.503 Å) 主引用文献 SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis. Nucleic Acids Res., 43, 2015
4RQE	human Seryl-tRNA synthetase dimer complexed with two molecules of tRNAsec 分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SERINE, Serine--tRNA ligase, ... 著者 Xie, W, Wang, C, Guo, Y, Tian, Q, Jia, Q. 登録日 2014-11-03 公開日 2015-11-04 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis. Nucleic Acids Res., 43, 2015
8PPU	Pyrococcus abyssi DNA polymerase D (PolD) in its editing mode bound to a primer/template substrate containing three consecutive mismatches 分子名称: DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA (5'-D(P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*(GS)P*(C7R)P*(PST)P*(PST)P*(PST))-3'), DNA polymerase II small subunit, ... 著者 Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. 登録日 2023-07-10 公開日 2023-12-20 最終更新日 2025-07-02 実験手法 ELECTRON MICROSCOPY (3.02 Å) 主引用文献 Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases. Nat Commun, 14, 2023
5N2G	Structure of the E9 DNA polymerase from vaccinia virus in complex with manganese 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Tarbouriech, N, Burmeister, W.P, Iseni, F. 登録日 2017-02-07 公開日 2017-11-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 The vaccinia virus DNA polymerase structure provides insights into the mode of processivity factor binding. Nat Commun, 8, 2017
8TQ2	Structure of the kinase lobe of human CDK8 kinase module 分子名称: Cyclin-C, Cyclin-dependent kinase 8, Mediator of RNA polymerase II transcription subunit 12, ... 著者 Chen, S.F, Chao, T.C, Kim, H.J, Tang, H.C, Khadka, S, Li, T, Murakami, K, Boyer, T.G, Tsai, K.L. 登録日 2023-08-06 公開日 2024-10-09 最終更新日 2025-05-28 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module. Mol.Cell, 84, 2024
8TQC	Structure of the human CDK8 kinase module 分子名称: Cyclin-C, Cyclin-dependent kinase 8, Mediator of RNA polymerase II transcription subunit 12, ... 著者 Chen, S.F, Chao, T.C, Kim, H.J, Tang, H.C, Khadka, S, Li, T, Murakami, K, Boyer, T.G, Tsai, K.L. 登録日 2023-08-06 公開日 2024-10-09 最終更新日 2025-05-21 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module. Mol.Cell, 84, 2024
9AVR	Human eIF4A-1 in complex with AMP-PNP, RNA, and the inhibitor silvestrol 分子名称: Eukaryotic initiation factor 4A-I, IODIDE ION, MAGNESIUM ION, ... 著者 Bhatt, G.B, Naineni, S.K, Cencic, R.C, Jiramongkolsiri, E.J, Huang, S.H, Pelletier, J.P, Nagar, B.N. 登録日 2024-03-04 公開日 2024-10-23 最終更新日 2025-05-07 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Protein-RNA interactions mediated by silvestrol-insight into a unique molecular clamp. Nucleic Acids Res., 52, 2024
6P1O	Post-catalytic nicked complex of human DNA Polymerase Mu with 1-nt gapped substrate containing template 8OG and newly incorporated dAMP 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Kaminski, A.M, Pedersen, L.C, Bebenek, K, Chiruvella, K.K, Ramsden, D.A, Kunkel, T.A. 登録日 2019-05-20 公開日 2019-09-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine. Nucleic Acids Res., 47, 2019
2LTO	TDRD3 complex 分子名称: DNA-directed RNA polymerase II subunit RPB1, Tudor domain-containing protein 3 著者 Sikorsky, T. 登録日 2012-05-30 公開日 2013-01-16 最終更新日 2024-11-20 実験手法 SOLUTION NMR 主引用文献 Recognition of asymmetrically dimethylated arginine by TDRD3. Nucleic Acids Res., 40, 2012
3RJ1	Architecture of the Mediator Head module 分子名称: Mediator of RNA polymerase II transcription subunit 11, Mediator of RNA polymerase II transcription subunit 17, Mediator of RNA polymerase II transcription subunit 18, ... 著者 Imasaki, T, Calero, G, Cai, G, Tsai, K.L, Yamada, K, Cardelli, F, Erdjument-Bromage, H, Tempst, P, Berger, I, Kornberg, G.L, Asturias, F.J, Kornberg, R.D, Takagi, Y. 登録日 2011-04-14 公開日 2011-07-27 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (4.3 Å) 主引用文献 Architecture of the Mediator head module. Nature, 475, 2011
8J9A	Solution structure of ABD3 (residues 453-561) of human MED15 isoform 2 分子名称: Mediator of RNA polymerase II transcription subunit 15 著者 Zhang, H, Li, Y. 登録日 2023-05-03 公開日 2024-05-08 最終更新日 2025-05-28 実験手法 SOLUTION NMR 主引用文献 The mechanism of YAP/TAZ transactivation and dual targeting for cancer therapy. Nat Commun, 16, 2025

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