PDB: 35140 件ウェブページステータス検索Chemie searchBIRD

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4L31	Tankyrase 2 in complex with methyl 4-(4-oxochromen-2-yl)benzoate 分子名称: GLYCEROL, SULFATE ION, Tankyrase-2, ... 著者 Narwal, M, Haikarainen, T, Lehtio, L. 登録日 2013-06-05 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem., 56, 2013
4ZK5	MAP4K4 in complex with inhibitor GNE-495 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 8-amino-N-[1-(cyclopropylcarbonyl)azetidin-3-yl]-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide, MAGNESIUM ION, ... 著者 Harris, S.F, Wu, P, Coons, M. 登録日 2015-04-29 公開日 2015-09-02 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. Acs Med.Chem.Lett., 6, 2015
4PXW	Crystal structure of human DCAF1 WD40 repeats (Q1250L) 分子名称: Protein VPRBP, UNKNOWN ATOM OR ION 著者 Xu, C, Tempel, W, He, H, Li, Y, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2014-03-25 公開日 2014-04-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Crystal structure of human DCAF1 WD40 repeats (Q1250L) TO BE PUBLISHED
4KZU	Crystal structure of human tankyrase 2 in complex with 4' -bromo flavone 分子名称: 2-(4-bromophenyl)-4H-chromen-4-one, GLYCEROL, SULFATE ION, ... 著者 Narwal, M, Haikarainen, T, Lehtio, L. 登録日 2013-05-30 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem., 56, 2013
4L0Y	Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 1) 分子名称: 5'-D(*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3', 5'-D(*GP*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3', Protein C-ets-1, ... 著者 Tahirov, T.H. 登録日 2013-06-01 公開日 2014-03-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis of Ets1 activation by Runx1. Leukemia, 28, 2014
4L18	Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 3) 分子名称: 5'-D(*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3', 5'-D(*GP*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3', GLYCEROL, ... 著者 Tahirov, T.H. 登録日 2013-06-02 公開日 2014-03-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis of Ets1 activation by Runx1. Leukemia, 28, 2014
2RQR	The solution structure of human DOCK2 SH3 domain - ELMO1 peptide chimera complex 分子名称: Engulfment and cell motility protein 1,Dedicator of cytokinesis protein 2 著者 Yokoyama, S, Tochio, N, Koshiba, S, Kigawa, T, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2009-10-21 公開日 2010-10-27 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms. Proc.Natl.Acad.Sci.USA, 109, 2012
4L32	Tankyrase 2 in complex with 2-[4-(4-methylpiperazine-1-carbonyl)phenyl]chromen-4-one 分子名称: 2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-4H-chromen-4-one, GLYCEROL, SULFATE ION, ... 著者 Narwal, M, Haikarainen, T, Lehtio, L. 登録日 2013-06-05 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem., 56, 2013
4L09	Crystal structure of human tankyrase 2 in complex with 4-(4-oxo-4H-chromen-2-yl)benzoic acid 分子名称: 4-(4-oxo-4H-chromen-2-yl)benzoic acid, GLYCEROL, SULFATE ION, ... 著者 Narwal, M, Haikarainen, T, Lehtio, L. 登録日 2013-05-31 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem., 56, 2013
4ZTD	Crystal Structure of Human PCNA in complex with a TRAIP peptide 分子名称: ALA-GLY-ALA-GLY-ALA, ALA-PHE-GLN-ALA-LYS-LEU-ASP-THR-PHE-LEU-TRP-SER, Proliferating cell nuclear antigen 著者 Montoya, G, Mortuza, G.B, Blanco, F.J, Ibanez de Opakua, A. 登録日 2015-05-14 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.199 Å) 主引用文献 TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress. J.Cell Biol., 212, 2016
7A05	NMR structure of D3-D4 domains of Vibrio vulnificus ribosomal protein S1 分子名称: 30S ribosomal protein S1 著者 Qureshi, N.S, Matzel, T, Cetiner, E.C, Schnieders, S, Jonker, H.R.A, Schwalbe, H, Fuertig, B. 登録日 2020-08-06 公開日 2021-06-23 最終更新日 2024-01-17 実験手法 SOLUTION NMR 主引用文献 NMR structure of the Vibrio vulnificus ribosomal protein S1 domains D3 and D4 provides insights into molecular recognition of single-stranded RNAs. Nucleic Acids Res., 49, 2021
5A52	The crystal structure of Arabidopsis thaliana CAR1 in complex with one calcium ion 分子名称: CALCIUM ION, CALCIUM-DEPENDENT LIPID-BINDING DOMAIN-CONTAINING PROTEIN, GLYCEROL, ... 著者 Fernandez, D, Marquez, J.A. 登録日 2015-06-16 公開日 2016-03-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Calcium-Dependent Oligomerization of Car Proteins at Cell Membrane Modulates Aba Signaling. Proc.Natl.Acad.Sci.USA, 113, 2016
4QGC	crystal structure of PKM2-K422R mutant 分子名称: GLYCEROL, POTASSIUM ION, Pyruvate kinase PKM, ... 著者 Wang, P, Sun, C, Zhu, T, Xu, Y. 登録日 2014-05-22 公開日 2015-02-25 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.296 Å) 主引用文献 Structural insight into mechanisms for dynamic regulation of PKM2. Protein Cell, 6, 2015
3FDL	Bim BH3 peptide in complex with Bcl-xL 分子名称: Apoptosis regulator Bcl-X, Bcl-2-like protein 11 著者 Fairlie, W.D, Lee, E.F, Smith, B.J, Czabotar, P.E, Colman, P.M. 登録日 2008-11-26 公開日 2009-03-10 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L) Angew.Chem.Int.Ed.Engl., 48, 2009
4PZ1	Crystal structure of a sHIP (UniProt Id: Q99XU0) mutant from Streptococcus pyogenes 分子名称: CALCIUM ION, CHLORIDE ION, sHIP 著者 Wisniewska, M, Happonen, L, Frick, I.-M, Bjorck, L, Streicher, W, Malmstrom, J, Wikstrom, M. 登録日 2014-03-28 公開日 2015-03-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Functional and structural properties of a novel protein and virulence factor (Protein sHIP) in Streptococcus pyogenes. J.Biol.Chem., 289, 2014
5ADS	Crystal structure of human tankyrase 2 in complex with OD39 分子名称: BICARBONATE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Haikarainen, T, Lehtio, L. 登録日 2015-08-24 公開日 2016-01-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Development and Structural Analysis of Adenosine Site Binding Tankyrase Inhibitors. Bioorg.Med.Chem.Lett., 26, 2016
5ADR	Crystal structure of human tankyrase 2 in complex with OD38 分子名称: BICARBONATE ION, N-(4-(((4-(4-methoxyphenyl)oxan-4- yl)methyl)carbamoyl)phenyl)-5-methylfuran-2-carboxamide, SULFATE ION, ... 著者 Haikarainen, T, Lehtio, L. 登録日 2015-08-24 公開日 2016-01-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Development and Structural Analysis of Adenosine Site Binding Tankyrase Inhibitors. Bioorg.Med.Chem.Lett., 26, 2016
5ADT	Crystal structure of human tankyrase 2 in complex with OD73 分子名称: BICARBONATE ION, N-[3-chloranyl-4-[[4-(4-methoxyphenyl)oxan-4-yl]methylcarbamoyl]phenyl]-2-methyl-1,3-oxazole-5-carboxamide, SULFATE ION, ... 著者 Haikarainen, T, Lehtio, L. 登録日 2015-08-24 公開日 2016-01-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Development and Structural Analysis of Adenosine Site Binding Tankyrase Inhibitors. Bioorg.Med.Chem.Lett., 26, 2016
3FKN	P38 kinase crystal structure in complex with RO7125 分子名称: 3-[2-chloro-5-(methylsulfonyl)phenyl]-6-(2,4-difluorophenoxy)-1H-pyrazolo[3,4-d]pyrimidine, Mitogen-activated protein kinase 14 著者 Kuglstatter, A, Ghate, M. 登録日 2008-12-17 公開日 2009-12-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mapping Binding Pocket Volume: Potential Applications towards Ligand Design and Selectivity To be Published
2RFO	Crystral Structure of the nucleoporin Nic96 分子名称: Nucleoporin NIC96 著者 Schrader, N, Stelter, P, Flemming, D, Kunze, K, Hurt, E, Vetter, I.R. 登録日 2007-10-01 公開日 2008-01-29 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis of the nic96 subcomplex organization in the nuclear pore channel. Mol.Cell, 29, 2008
3FMH	P38 kinase crystal structure in complex with 6-(2,4-Difluoro-phenoxy)-8-methyl-2-((R)-1-methyl-2-tetrazol-2-yl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one 分子名称: 6-(2,4-difluorophenoxy)-8-methyl-2-{[(1R)-1-methyl-2-(2H-tetrazol-2-yl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, Mitogen-activated protein kinase 14 著者 Kuglstatter, A, Ghate, M. 登録日 2008-12-22 公開日 2009-12-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The Discovery of Pamapimod and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase To be Published
7V7C	CryoEM structure of DDB1-VprBP-Vpr-UNG2(94-313) complex 分子名称: DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1, Protein Vpr, ... 著者 Wang, D, Xu, J, Liu, Q, Xiang, Y. 登録日 2021-08-21 公開日 2022-08-31 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural insights into the HIV-1 Vpr mediated ubiquitination through the Cullin-RING E3 ubiquitin ligase To Be Published
7V7B	CryoEM structure of DDB1-VprBP complex in ARM-up conformation 分子名称: DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1 著者 Wang, D, Xu, J, Liu, Q, Xiang, Y. 登録日 2021-08-21 公開日 2022-08-31 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structural insights into the HIV-1 Vpr mediated ubiquitination through the Cullin-RING E3 ubiquitin ligase To Be Published
2RR9	The solution structure of the K63-Ub2:tUIMs complex 分子名称: Putative uncharacterized protein UIMC1, ubiquitin 著者 Sekiyama, N, Jee, J, Isogai, S, Akagi, K, Huang, T, Ariyoshi, M, Tochio, H, Shirakawa, M. 登録日 2010-06-16 公開日 2011-07-06 最終更新日 2011-07-13 実験手法 SOLUTION NMR 主引用文献 The solution structure of the K63-Ub2:tUIMs complex To be Published
3FLN	P38 kinase crystal structure in complex with R1487 分子名称: 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one, Mitogen-activated protein kinase 14 著者 Kuglstatter, A, Knapp, M. 登録日 2008-12-19 公開日 2009-12-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The Discovery of Pamapimod, R1503 and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase To be Published

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