4KZU

Crystal structure of human tankyrase 2 in complex with 4' -bromo flavone

Summary for 4KZU

Entry DOI	10.2210/pdb4kzu/pdb
Related	4BS4 4HKI 4KZL 4KZQ 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34
Descriptor	Tankyrase-2, 2-(4-bromophenyl)-4H-chromen-4-one, ZINC ION, ... (7 entities in total)
Functional Keywords	protein-ligand complex, diphtheria toxin like fold, transferase, adp-ribosylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: Q9H2K2 Q9H2K2
Total number of polymer chains	4
Total formula weight	55844.96
Authors	Narwal, M.,Haikarainen, T.,Lehtio, L. (deposition date: 2013-05-30, release date: 2013-10-30, Last modification date: 2023-09-20)
Primary citation	Narwal, M.,Koivunen, J.,Haikarainen, T.,Obaji, E.,Legala, O.E.,Venkannagari, H.,Joensuu, P.,Pihlajaniemi, T.,Lehtio, L. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem., 56:7880-7889, 2013 Cited by PubMed: 24116873 DOI: 10.1021/jm401463y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation