4L0T
Tankyrase 2 in complex with 4'-nitro flavone
Summary for 4L0T
Entry DOI | 10.2210/pdb4l0t/pdb |
Related | 4BS4 4HKI 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 |
Descriptor | Tankyrase-2, 2-(4-nitrophenyl)-4H-chromen-4-one, SULFATE ION, ... (7 entities in total) |
Functional Keywords | protein-ligand complex, diphtheria toxin like fold, transferase, adp-ribosylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: Q9H2K2 Q9H2K2 |
Total number of polymer chains | 4 |
Total formula weight | 55777.16 |
Authors | Narwal, M.,Haikarainen, T.,Lehtio, L. (deposition date: 2013-06-01, release date: 2013-10-30, Last modification date: 2023-09-20) |
Primary citation | Narwal, M.,Koivunen, J.,Haikarainen, T.,Obaji, E.,Legala, O.E.,Venkannagari, H.,Joensuu, P.,Pihlajaniemi, T.,Lehtio, L. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem., 56:7880-7889, 2013 Cited by PubMed: 24116873DOI: 10.1021/jm401463y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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