5ADR

Crystal structure of human tankyrase 2 in complex with OD38

Summary for 5ADR

• Entry DOI: 10.2210/pdb5adr/pdb
• Related: 5ADQ 5ADS 5ADT
• Descriptor: TANKYRASE-2, SULFATE ION, N-(4-(((4-(4-methoxyphenyl)oxan-4- yl)methyl)carbamoyl)phenyl)-5-methylfuran-2-carboxamide, ... (7 entities in total)
• Functional Keywords: transferase, protein-ligand complex, diphtheria toxin like fold, adp- ribosylation, transferase-transferase inhibitor complex
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm: Q9H2K2 Q9H2K2
• Total number of polymer chains: 2
• Total formula weight: 27955.64

Authors

Haikarainen, T.,Lehtio, L. (deposition date: 2015-08-24, release date: 2016-01-13, Last modification date: 2016-01-20)

• Primary citation: Haikarainen, T.,Waaler, J.,Ignatev, A.,Nkizinkiko, Y.,Venkannagari, H.,Obaji, E.,Krauss, S.,Lehtio, L.; Development and Structural Analysis of Adenosine Site Binding Tankyrase Inhibitors.; Bioorg.Med.Chem.Lett., 26:328-, 2016; PubMed: 26706174; DOI: 10.1016/J.BMCL.2015.12.018

Experimental method

X-RAY DIFFRACTION (2.1 Å)