5ADR
Crystal structure of human tankyrase 2 in complex with OD38
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TANKYRASE-2 | polymer | 191 | 21824.5 | 1 | UniProt (Q9H2K2) Pfam (PF00644) | HOMO SAPIENS (HUMAN) | TANK2, ADP-RIBOSYLTRANSFERASE DIPHTHERIA TOXIN-LIKE 6, ARTD 6, POLY ADP-RIBOSE POLYMERASE 5B, TNKS-2, TRF1-INTERACTING ANKYRIN - RELATED ADP-RIBOSE POLYMERASE 2, TANKYRASE II, TANKYRASE-LIKE PROTEIN, TANKYRASE-RELATED PROTEIN |
| 2 | B (B) | TANKYRASE-2 | polymer | 48 | 5364.0 | 1 | UniProt (Q9H2K2) | HOMO SAPIENS (HUMAN) | TANK2, ADP-RIBOSYLTRANSFERASE DIPHTHERIA TOXIN-LIKE 6, ARTD 6, POLY ADP-RIBOSE POLYMERASE 5B, TNKS-2, TRF1-INTERACTING ANKYRIN - RELATED ADP-RIBOSE POLYMERASE 2, TANKYRASE II, TANKYRASE-LIKE PROTEIN, TANKYRASE-RELATED PROTEIN |
| 3 | C, G (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | D (A) | N-(4-(((4-(4-methoxyphenyl)oxan-4- yl)methyl)carbamoyl)phenyl)-5-methylfuran-2-carboxamide | non-polymer | 448.5 | 1 | Chemie (QS5) | |||
| 5 | E (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | F (A) | BICARBONATE ION | non-polymer | 61.0 | 1 | Chemie (BCT) | |||
| 7 | H, I (A, B) | water | water | 18.0 | 158 | Chemie (HOH) |
Sequence modifications
A: 946 - 1113 (UniProt: Q9H2K2)
| PDB | External Database | Details |
|---|---|---|
| Met 923 | - | expression tag |
| His 924 | - | expression tag |
| His 925 | - | expression tag |
| His 926 | - | expression tag |
| His 927 | - | expression tag |
| His 928 | - | expression tag |
| His 929 | - | expression tag |
| Ser 930 | - | expression tag |
| Ser 931 | - | expression tag |
| Gly 932 | - | expression tag |
| Val 933 | - | expression tag |
| Asp 934 | - | expression tag |
| Leu 935 | - | expression tag |
| Gly 936 | - | expression tag |
| Thr 937 | - | expression tag |
| Glu 938 | - | expression tag |
| Asn 939 | - | expression tag |
| Leu 940 | - | expression tag |
| Tyr 941 | - | expression tag |
| Phe 942 | - | expression tag |
| Gln 943 | - | expression tag |
| Ser 944 | - | expression tag |
| Met 945 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27188.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 767.1 | |
| All* | Total formula weight | 27955.6 |
