PDB: 13422 件ウェブページステータス検索Chemie searchBIRD

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6ANU	Cryo-EM structure of F-actin complexed with the beta-III-spectrin actin-binding domain 分子名称: Actin, cytoplasmic 1, Spectrin beta chain, ... 著者 Wang, F, Orlova, A, Avery, A.W, Hays, T.S, Egelman, E.H. 登録日 2017-08-14 公開日 2017-11-22 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (7 Å) 主引用文献 Structural basis for high-affinity actin binding revealed by a beta-III-spectrin SCA5 missense mutation. Nat Commun, 8, 2017
5Y39	Crystal structure of Ragulator complex (p18 76-145) 分子名称: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... 著者 Zhang, T, Ding, J. 登録日 2017-07-28 公開日 2017-12-06 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1 Nat Commun, 8, 2017
3LUE	Model of alpha-actinin CH1 bound to F-actin 分子名称: Actin, cytoplasmic 1, Alpha-actinin-3 著者 Galkin, V.E, Orlova, A, Salmazo, A, Djinovic-Carugo, K, Egelman, E.H. 登録日 2010-02-17 公開日 2010-04-28 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (15 Å) 主引用文献 Opening of tandem calponin homology domains regulates their affinity for F-actin. Nat.Struct.Mol.Biol., 17, 2010
5YDE	Crystal structure of a disease-related gene, hCDC73(1-111) 分子名称: Parafibromin 著者 Sun, W, Kuang, X.L, Liu, Y.P, Tian, L.F, Yan, X.X, Xu, W.Q. 登録日 2017-09-13 公開日 2017-12-20 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.023 Å) 主引用文献 Crystal structure of the N-terminal domain of human CDC73 and its implications for the hyperparathyroidism-jaw tumor (HPT-JT) syndrome Sci Rep, 7, 2017
6B75	Crystal Structure of human NAMPT in complex with NVP-LOQ594 分子名称: 4-[(piperazin-1-yl)methyl]-N-{[4-({[(pyridin-3-yl)methyl]carbamoyl}amino)phenyl]methyl}benzamide, Nicotinamide phosphoribosyltransferase 著者 Weihofen, W.A, Thigale, S. 登録日 2017-10-03 公開日 2018-10-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors To Be Published
2M9W	Solution NMR Structure of Transcription Factor GATA-4 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR4783B 分子名称: Transcription factor GATA-4, ZINC ION 著者 Xu, X, Eletsky, A, Lee, D, Kohn, E, Janjua, H, Xiao, R, Acton, T.B, Everett, J.K, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) 登録日 2013-06-20 公開日 2013-07-10 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution NMR Structure of a Transcription Factor GATA-4 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR4783B To be Published
5YBC	X-ray structure of native ETS-domain domain of Ergp55 分子名称: GLYCEROL, Transcriptional regulator ERG 著者 Saxena, A.K, Gangwar, S.P. 登録日 2017-09-04 公開日 2018-09-19 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Comparative structure analysis of the ETSi domain of ERG3 and its complex with the E74 promoter DNA sequence Acta Crystallogr F Struct Biol Commun, 74, 2018
7B5S	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1 分子名称: Cullin-1, E3 ubiquitin-protein ligase ARIH1, E3 ubiquitin-protein ligase RBX1, ... 著者 Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. 登録日 2020-12-07 公開日 2021-02-10 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
4CNI	Crystal structure of the Fab portion of Olokizumab in complex with IL- 6 分子名称: INTERLEUKIN-6, OLOKIZUMAB HEAVY CHAIN, FAB PORTION, ... 著者 Shaw, S, Bourne, T, Meier, C, Carrington, B, Gelinas, R, Henry, A, Popplewell, A, Adams, R, Baker, T, Rapecki, S, Marshall, D, Neale, H, Lawson, A. 登録日 2014-01-22 公開日 2014-04-30 最終更新日 2019-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery and Characterization of Olokizumab: A Humanized Antibody Targeting Interleukin-6 and Neutralizing Gp130-Signaling. Mabs, 6, 2014
6ATB	Crystal Structure of human NAMPT in complex with NVP-LOD812 分子名称: DIMETHYL SULFOXIDE, GLYCEROL, N-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-N'-[(pyridin-3-yl)methyl]urea, ... 著者 Weihofen, W.A, Thigale, S. 登録日 2017-08-28 公開日 2018-09-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors To Be Published
7T7T	Structure of TSK/BRU1 bound to histone H3.1 分子名称: Histone H3.1, Protein TONSOKU 著者 Davarinejad, H, Couture, J.F. 登録日 2021-12-15 公開日 2022-03-30 実験手法 X-RAY DIFFRACTION (3.17 Å) 主引用文献 The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication. Science, 375, 2022
5YJ8	Identification of a small molecule inhibitor for the Tudor domain of TDRD3 分子名称: 5-(aminomethyl)-1,3-dimethyl-benzimidazol-2-one, SULFATE ION, Tudor domain-containing protein 3 著者 Liu, J, Ruan, K. 登録日 2017-10-09 公開日 2018-05-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.762 Å) 主引用文献 Structural plasticity of the TDRD3 Tudor domain probed by a fragment screening hit. FEBS J., 285, 2018
6B8J	Co-structure of human glycogen synthase kinase beta with a selective (5-imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine inhibitor 分子名称: CHIR99021, GLYCEROL, Glycogen synthase kinase-3 beta, ... 著者 Bussiere, D.E. 登録日 2017-10-08 公開日 2017-11-08 実験手法 X-RAY DIFFRACTION (2.595 Å) 主引用文献 Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3. J. Med. Chem., 60, 2017
3NTP	Human Pin1 complexed with reduced amide inhibitor 分子名称: (2R)-2-(acetylamino)-3-[(2S)-2-{[2-(1H-indol-3-yl)ethyl]carbamoyl}pyrrolidin-1-yl]propyl dihydrogen phosphate, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 著者 Zhang, Y. 登録日 2010-07-05 公開日 2012-01-04 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.762 Å) 主引用文献 A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state. Biochemistry, 50, 2011
5Y3A	Crystal structure of Ragulator complex (p18 49-161) 分子名称: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... 著者 Zhang, T, Ding, J. 登録日 2017-07-28 公開日 2017-12-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1. Nat Commun, 8, 2017
6AX3	Complex structure of JMJD5 and Symmetric Dimethyl-Arginine (SDMA) 分子名称: 2-OXOGLUTARIC ACID, Lysine-specific demethylase 8, N3, ... 著者 Lee, S, Liu, H, Wang, Y, Dai, S, Zhang, G. 登録日 2017-09-06 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7. Sci Rep, 8, 2018
7B15	14-3-3sigma in complex with SHN3pT869 phosphopeptide crystal structure 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, SHN3pT869 著者 Soini, L, Leysen, S, Davis, J, Ottmann, C. 登録日 2020-11-23 公開日 2021-09-29 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 14-3-3 sigma in complex with phosphopeptides To Be Published
7B13	14-3-3sigma in complex with SHN3pS542 phosphopeptide crystal structure 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, SHN3pS542 著者 Soini, L, Leysen, S, Davis, J, Ottmann, C. 登録日 2020-11-23 公開日 2021-09-29 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 14-3-3 sigma in complex with phosphopeptides To Be Published
5YDF	Crystal structure of a disease-related gene, hCDC73(1-100) 分子名称: Parafibromin 著者 Sun, W, Kuang, X.L, Liu, Y.P, Tian, L.F, Yan, X.X, Xu, W.Q. 登録日 2017-09-13 公開日 2017-12-20 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.399 Å) 主引用文献 Crystal structure of the N-terminal domain of human CDC73 and its implications for the hyperparathyroidism-jaw tumor (HPT-JT) syndrome Sci Rep, 7, 2017
3MHR	14-3-3 sigma in complex with YAP pS127-peptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Schumacher, B, Skwarczynska, M, Rose, R, Ottmann, C. 登録日 2010-04-08 公開日 2010-09-15 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Structure of a 14-3-3[sigma]-YAP phosphopeptide complex at 1.15 A resolution Acta Crystallogr.,Sect.F, 66, 2010
6B76	Crystal Structure of human NAMPT in complex with NVP-LVR596 分子名称: (1S,2S)-N-{4-[(1S)-1-(propanoylamino)ethyl]phenyl}-2-(pyridin-3-yl)cyclopropane-1-carboxamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION 著者 Weihofen, W.A, Thigale, S. 登録日 2017-10-03 公開日 2018-10-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors To Be Published
6B9X	Crystal structure of Ragulator 分子名称: Hepatitis B virus x interacting protein, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... 著者 SU, M.-Y, Hurley, J.H. 登録日 2017-10-11 公開日 2017-11-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex. Mol. Cell, 68, 2017
5YBD	X-ray structure of ETS domain of Ergp55 in complex with E74DNA 分子名称: DNA (5'-D(P*AP*CP*CP*GP*GP*AP*AP*GP*T)-3'), DNA (5'-D(P*CP*AP*CP*TP*TP*CP*CP*GP*GP*T)-3'), Transcriptional regulator ERG 著者 Saxena, A.K, Gangwar, S.P. 登録日 2017-09-04 公開日 2018-11-14 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.769 Å) 主引用文献 Comparative structure analysis of the ETSi domain of ERG3 and its complex with the E74 promoter DNA sequence Acta Crystallogr F Struct Biol Commun, 74, 2018
7AW9	CCAAT-binding complex and HapX bound to Aspergillus fumigatus cccA DNA 分子名称: BZIP domain-containing protein, CBFD_NFYB_HMF domain-containing protein, CHLORIDE ION, ... 著者 Huber, E.M, Groll, M. 登録日 2020-11-06 公開日 2022-04-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structural insights into cooperative DNA recognition by the CCAAT-binding complex and its bZIP transcription factor HapX. Structure, 30, 2022
7AW7	CCAAT-binding complex and HapX bound to Aspergillus nidulans cccA DNA 分子名称: BZIP domain-containing protein, CBFD_NFYB_HMF domain-containing protein, CHLORIDE ION, ... 著者 Huber, E.M, Groll, M. 登録日 2020-11-06 公開日 2022-04-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structural insights into cooperative DNA recognition by the CCAAT-binding complex and its bZIP transcription factor HapX. Structure, 30, 2022

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