8BH4
 
 | |
5DGS
 | |
8EVS
 | | Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure II | | 分子名称: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | | 著者 | Zhao, Y, Rai, J, Li, H. | | 登録日 | 2022-10-20 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-11-01 | | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | | 主引用文献 | Regulation of translation by ribosomal RNA pseudouridylation.
Sci Adv, 9, 2023
|
|
8FLA
 | |
7Q0F
 | | Structure of Candida albicans 80S ribosome in complex with phyllanthoside | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose, ... | | 著者 | Zgadzay, Y, Kolosova, O, Stetsenko, A, Jenner, L, Guskov, A, Yusupova, G, Yusupov, M. | | 登録日 | 2021-10-14 | | 公開日 | 2022-05-18 | | 最終更新日 | 2022-06-08 | | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | | 主引用文献 | E-site drug specificity of the human pathogen Candida albicans ribosome.
Sci Adv, 8, 2022
|
|
8G5Z
 | | mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state) | | 分子名称: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | | 著者 | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | | 登録日 | 2023-02-14 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | | 主引用文献 | mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
|
|
8HFR
 | | NPC-trapped pre-60S particle | | 分子名称: | 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | 著者 | Li, Z.Q, Chen, S.J, Sui, S.F. | | 登録日 | 2022-11-12 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-06-28 | | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | | 主引用文献 | Nuclear export of pre-60S particles through the nuclear pore complex.
Nature, 618, 2023
|
|
8RPY
 | | Escherichia coli 50S subunit in complex with the antimicrobial peptide Api137 | | 分子名称: | 23S ribosomal RNA, 5S ribosomal RNA, Apidaecins type 137, ... | | 著者 | Lauer, S, Nikolay, R, Spahn, C. | | 登録日 | 2024-01-17 | | 公開日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | | 主引用文献 | Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88.
Nat Commun, 15, 2024
|
|
4ISG
 | | Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-[4-(methylsulfonyl)-2-oxopiperazin-1-yl]-N-(1,3-thiazol-2-yl)propanamide | | 分子名称: | (2S)-3-cyclohexyl-2-[4-(methylsulfonyl)-2-oxopiperazin-1-yl]-N-(1,3-thiazol-2-yl)propanamide, Glucokinase, IODIDE ION, ... | | 著者 | Hosfield, D, Skene, R.J. | | 登録日 | 2013-01-16 | | 公開日 | 2013-03-20 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.645 Å) | | 主引用文献 | Design, synthesis and SAR of novel glucokinase activators.
Bioorg.Med.Chem.Lett., 23, 2013
|
|
8Y36
 | | cryo-EM structure of Staphylococcus aureus(ATCC 29213) 50S ribosome in complex with MCX-190. | | 分子名称: | 23S ribosomal RNA, 5S ribosomal RNA, 7-[4-[3-[[(1~{S},2~{R},5~{R},6~{S},7~{S},8~{R},9~{R},11~{R},13~{R},14~{R})-8-[(2~{S},3~{R},4~{S},6~{R})-4-(dimethylamino)-6-methyl-3-oxidanyl-oxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-tris(oxidanylidene)-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl]oxycarbonylamino]propoxy]but-1-ynyl]-1-methyl-4-oxidanylidene-quinoline-3-carboxylic acid, ... | | 著者 | Li, Y, Lu, G, Li, J, Pei, X, Lin, J. | | 登録日 | 2024-01-28 | | 公開日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | | 主引用文献 | Synthetic macrolides overcoming MLS B K-resistant pathogens.
Cell Discov, 10, 2024
|
|
4EJ2
 | | Crystal structure of GPb in complex with DK10 | | 分子名称: | 1-(beta-D-glucopyranosyl)-5-(hept-1-yn-1-yl)pyrimidine-2,4(1H,3H)-dione, Glycogen phosphorylase, muscle form | | 著者 | Kantsadi, A.L, Skamnaki, V.T, Leonidas, D.D. | | 登録日 | 2012-04-06 | | 公開日 | 2012-07-25 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: Synthesis, biochemical and biological assessment.
Eur.J.Med.Chem., 54, 2012
|
|
1YI2
 | | Crystal Structure Of Erythromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui | | 分子名称: | 23S Ribosomal RNA, 50S RIBOSOMAL PROTEIN L10E, 50S RIBOSOMAL PROTEIN L11P, ... | | 著者 | Tu, D, Blaha, G, Moore, P.B, Steitz, T.A. | | 登録日 | 2005-01-11 | | 公開日 | 2005-04-26 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance.
Cell(Cambridge,Mass.), 121, 2005
|
|
3T3I
 | | Glycogen Phosphorylase b in complex with GlcCF3U | | 分子名称: | 1-(beta-D-glucopyranosyl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione, Glycogen phosphorylase, muscle form | | 著者 | Kantsadi, A.L, Skamnaki, V.T, Leonidas, D.D. | | 登録日 | 2011-07-25 | | 公開日 | 2012-02-15 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | The sigma-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b
Chemmedchem, 7, 2012
|
|
7S0L
 | |
4AZ8
 | | Crystal structure of the complex of the Caf1M:Caf1 chaperone:subunit preassembly complex carrying the KDKDTN insertion at the F1G1 loop region | | 分子名称: | CHAPERONE PROTEIN CAF1M, F1 CAPSULE ANTIGEN | | 著者 | Yu, X.D, Dubnovitsky, A, Pudney, A.F, MacIntyre, S, Knight, S.D, Zavialov, A.V. | | 登録日 | 2012-06-24 | | 公開日 | 2012-09-26 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Allosteric Mechanism Controls Traffic in the Chaperone/Usher Pathway.
Structure, 20, 2012
|
|
5KSX
 | | Crystal structure of human FPPS in complex with an allosteric inhibitor AM-02-072 | | 分子名称: | Farnesyl pyrophosphate synthase, PHOSPHATE ION, [[(2~{S})-2-[[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoyl]amino]phosphonic acid | | 著者 | Park, J, Matralis, A, Tsantrizos, Y.S, Berghuis, A.M. | | 登録日 | 2016-07-10 | | 公開日 | 2017-03-15 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase.
J. Med. Chem., 60, 2017
|
|
8FLF
 | |
8G2C
 | | Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.65A resolution | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Aleksandrova, E.V, Wu, K.J.Y, Tresco, B.I.C, Syroegin, E.A, Killeavy, E.E, Balasanyants, S.M, Svetlov, M.S, Gregory, S.T, Atkinson, G.C, Myers, A.G, Polikanov, Y.S. | | 登録日 | 2023-02-03 | | 公開日 | 2023-12-27 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it.
Nat.Chem.Biol., 20, 2024
|
|
8FC5
 | | Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and azithromycin at 2.65A resolution | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | | 著者 | Chen, C.-W, Syroegin, E.A, Svetlov, M.S, Polikanov, Y.S. | | 登録日 | 2022-12-01 | | 公開日 | 2023-07-26 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A.
Nat Commun, 14, 2023
|
|
6SKG
 | | Cryo-EM Structure of T. kodakarensis 70S ribosome in TkNat10 deleted strain | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Matzov, D, Sas-Chen, A, Thomas, J.M, Santangelo, T, Meier, J.L, Schwartz, S, Shalev-Benami, M. | | 登録日 | 2019-08-15 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | | 主引用文献 | Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping.
Nature, 583, 2020
|
|
6HMA
 | | Improved model derived from cryo-EM map of Staphylococcus aureus large ribosomal subunit | | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | | 著者 | Eyal, Z, Cimicata, G, Matzov, D, Fox, T, de Val, N, Zimmerman, E, Bashan, A, Yonath, A. | | 登録日 | 2018-09-12 | | 公開日 | 2018-11-14 | | 最終更新日 | 2020-05-27 | | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | | 主引用文献 | Improved model derived from cryo-EM map of Staphylococcus aureus large ribosomal subunit
To Be Published
|
|
8EMS
 | | Cryo-EM structure of human liver glycogen phosphorylase | | 分子名称: | Glycogen phosphorylase, liver form, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Su, C, Lyu, M, Zhang, Z, Yu, E.W. | | 登録日 | 2022-09-28 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | | 主引用文献 | High-resolution structural-omics of human liver enzymes.
Cell Rep, 42, 2023
|
|
4F9O
 | |
7CHY
 | |
7RYF
 | | A. baumannii Ribosome-TP-6076 complex: P-site tRNA 70S | | 分子名称: | (4S,4aS,5aR,12aS)-4-(diethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-8-[(2S)-pyrrolidin-2-yl]-7-(trifluoromethyl)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, 16S Ribosomal RNA, 23S ribosomal RNA, ... | | 著者 | Morgan, C.E, Yu, E.W. | | 登録日 | 2021-08-25 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | | 主引用文献 | An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii.
Mbio, 13, 2022
|
|
