7Q1Z
 
 | | Structure of formaldehyde cross-linked SARS-CoV-2 S glycoprotein | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | 著者 | Sulbaran, G, Effantin, G, Schoehn, G, Weissenhorn, W. | | 登録日 | 2021-10-22 | | 公開日 | 2022-03-09 | | 最終更新日 | 2022-03-16 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects macaques from infection.
Cell Rep Med, 3, 2022
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7PH1
 | | Trypsin in complex with BPTI mutant (2S)-2-amino-4-monofluorobutanoic acid | | 分子名称: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | | 著者 | Dimos, N, Leppkes, J, Koksch, B, Loll, B. | | 登録日 | 2021-08-16 | | 公開日 | 2022-03-30 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | | 主引用文献 | Water Network in the Binding Pocket of Fluorinated BPTI-Trypsin Complexes─Insights from Simulation and Experiment.
J.Phys.Chem.B, 126, 2022
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7PG5
 | | Crystal Structure of PI3Kalpha | | 分子名称: | GLYCEROL, PHOSPHATE ION, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... | | 著者 | Gong, G, Pinotsis, N, Williams, R.L, Vanhaesebroeck, B. | | 登録日 | 2021-08-13 | | 公開日 | 2022-08-24 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.20029068 Å) | | 主引用文献 | A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration.
Nature, 618, 2023
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7PG6
 | | Crystal Structure of PI3Kalpha in complex with the inhibitor NVP-BYL719 | | 分子名称: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... | | 著者 | Gong, G, Pinotsis, N, Williams, R.L, Vanhaesebroeck, B. | | 登録日 | 2021-08-13 | | 公開日 | 2022-08-24 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.49943733 Å) | | 主引用文献 | A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration.
Nature, 618, 2023
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8D36
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8DAO
 | | Crystal structure of SARS-CoV-2 spike stem fusion peptide in complex with neutralizing antibody COV44-79 | | 分子名称: | COV44-79 heavy chain constant domain, COV44-79 heavy chain variable domain, COV44-79 light chain constant domain, ... | | 著者 | Lin, T.H, Lee, C.C.D, Yuan, M, Wilson, I.A. | | 登録日 | 2022-06-13 | | 公開日 | 2022-07-27 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Broadly neutralizing antibodies target the coronavirus fusion peptide.
Science, 377, 2022
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8D6Z
 | | Crystal structure of SARS-CoV-2 spike stem fusion peptide in complex with neutralizing antibody COV91-27 | | 分子名称: | Neutralizing antibody COV91-27 heavy chain, Neutralizing antibody COV91-27 light chain, Spike protein S2 fusion peptide | | 著者 | Lee, C.C.D, Lin, T.H, Yuan, M, Wilson, I.A. | | 登録日 | 2022-06-06 | | 公開日 | 2022-07-27 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Broadly neutralizing antibodies target the coronavirus fusion peptide.
Science, 377, 2022
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7Q0B
 | | Human GYS1-GYG1 complex inhibited state | | 分子名称: | Glycogen [starch] synthase, muscle, Glycogenin-1 | | 著者 | McCorvie, T.J, Shrestha, L, Froese, D.S, Ferreira, I.M, Yue, W.W. | | 登録日 | 2021-10-14 | | 公開日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate.
Nat.Struct.Mol.Biol., 29, 2022
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7QLL
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7QLI
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7QLK
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7SWW
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7SWX
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7QAP
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7QAL
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7QAO
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7QAM
 | | Three-dimensional structure of the PGAM5 WT TMD | | 分子名称: | Serine/threonine-protein phosphatase PGAM5, mitochondrial | | 著者 | Silber, M, Muhle-Goll, C. | | 登録日 | 2021-11-17 | | 公開日 | 2022-05-04 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Cleavage of mitochondrial homeostasis regulator PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state.
J.Biol.Chem., 298, 2022
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7TP3
 | | Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody K288.2 | | 分子名称: | CACODYLATE ION, K288.2 heavy chain, K288.2 light chain, ... | | 著者 | Yuan, M, Zhu, X, Wilson, I.A. | | 登録日 | 2022-01-24 | | 公開日 | 2022-02-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques.
Sci Transl Med, 14, 2022
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7QLJ
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7TXD
 | | Cryo-EM structure of BG505 SOSIP HIV-1 Env trimer in complex with CD4 receptor (D1D2) and broadly neutralizing darpin bnD.9 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Broadly neutralizing darpin bnd.9, ... | | 著者 | Cerutti, G, Gorman, J, Kwong, P.D, Shapiro, L. | | 登録日 | 2022-02-08 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | | 主引用文献 | Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization.
Nat.Struct.Mol.Biol., 30, 2023
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7QLM
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7QLO
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7QLN
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7UMM
 | | H1 Solomon Islands 2006 hemagglutinin in complex with Ab109 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | | 著者 | Windsor, I.W, Caradonna, T.M, Schmidt, A.G. | | 登録日 | 2022-04-07 | | 公開日 | 2022-11-23 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | An epitope-enriched immunogen expands responses to a conserved viral site.
Cell Rep, 41, 2022
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7RFP
 | | Mouse GITR (mGITR) with DTA-1 Fab fragment | | 分子名称: | DTA-1 (heavy chain), DTA-1 (light chain), Tumor necrosis factor receptor superfamily member 18,Enhanced green fluorescent protein | | 著者 | Meyerson, J.R, He, C. | | 登録日 | 2021-07-14 | | 公開日 | 2022-03-09 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism.
Sci Adv, 8, 2022
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