5UVG
 
 | | Crystal structure of the human neutral sphingomyelinase 2 (nSMase2) catalytic domain with insertion deleted and calcium bound | | 分子名称: | CALCIUM ION, Sphingomyelin phosphodiesterase 3,Sphingomyelin phosphodiesterase 3 | | 著者 | Airola, M.V, Guja, K.E, Garcia-Diaz, M, Hannun, Y.A. | | 登録日 | 2017-02-20 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.849 Å) | | 主引用文献 | Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2CC0
 | | Family 4 carbohydrate esterase from Streptomyces lividans in complex with acetate | | 分子名称: | ACETATE ION, ACETYL-XYLAN ESTERASE, ZINC ION | | 著者 | Taylor, E.J, Gloster, T.M, Turkenburg, J.P, Vincent, F, Brzozowski, A.M, Dupont, C, Shareck, F, Centeno, M.S.J, Prates, J.A.M, Puchart, V, Ferreira, L.M.A, Fontes, C.M.G.A, Biely, P, Davies, G.J. | | 登録日 | 2006-01-10 | | 公開日 | 2006-01-23 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure and Activity of Two Metal-Ion Dependent Acetyl Xylan Esterases Involved in Plant Cell Wall Degradation Reveals a Close Similarity to Peptidoglycan Deacetylases
J.Biol.Chem., 281, 2006
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1JCQ
 | | CRYSTAL STRUCTURE OF HUMAN PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYL DIPHOSPHATE AND THE PEPTIDOMIMETIC INHIBITOR L-739,750 | | 分子名称: | 2(S)-{2(S)-[2(R)-AMINO-3-MERCAPTO]PROPYLAMINO-3(S)-METHYL}PENTYLOXY-3-PHENYLPROPIONYLMETHIONINE SULFONE, ACETIC ACID, FARNESYL DIPHOSPHATE, ... | | 著者 | Long, S.B, Casey, P.J, Beese, L.S. | | 登録日 | 2001-06-11 | | 公開日 | 2001-11-02 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.
Proc.Natl.Acad.Sci.USA, 98, 2001
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8GDY
 | | Crystal structure of the human PDI first domain with 9 mutations | | 分子名称: | 1,2-ETHANEDIOL, Protein disulfide-isomerase, THIOCYANATE ION | | 著者 | Forouhar, F, Banayan, N.E, Loughlin, B.L, Singh, S, Wong, V, Hunt, H.S, Handelman, S.K, Price, N, Hunt, J.F. | | 登録日 | 2023-03-06 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Systematic enhancement of protein crystallization efficiency by bulk lysine-to-arginine (KR) substitution.
Protein Sci., 33, 2024
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1GL4
 | | Nidogen-1 G2/Perlecan IG3 Complex | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN, NIDOGEN-1, ... | | 著者 | Kvansakul, M, Hopf, M, Ries, A, Timpl, R, Hohenester, E. | | 登録日 | 2001-08-23 | | 公開日 | 2001-11-28 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural Basis for the High-Affinity Interaction of Nidogen-1 with Immunoglobulin-Like Domain 3 of Perlecan
Embo J., 20, 2001
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8GDU
 | | Crystal structure of a mutant methyl transferase from Methanosarcina acetivorans, Northeast Structural Genomics Consortium (NESG) Target MvR53-11M | | 分子名称: | Methyltransferase domain-containing protein, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Forouhar, F, Banayan, N.E, Loughlin, B.L, Singh, S, Wong, V, Hunt, H.S, Handelman, S.K, Price, N, Hunt, J.F. | | 登録日 | 2023-03-06 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Systematic enhancement of protein crystallization efficiency by bulk lysine-to-arginine (KR) substitution.
Protein Sci., 33, 2024
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1VZ5
 | | Succinate Complex of AtsK | | 分子名称: | PUTATIVE ALKYLSULFATASE ATSK, SUCCINIC ACID | | 著者 | Mueller, I, Stueckl, A.C, Uson, I, Kertesz, M. | | 登録日 | 2004-05-14 | | 公開日 | 2004-11-15 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Succinate Complex Crystal Structures of the Alpha-Ketoglutarate-Dependent Dioxygenase Atsk: Steric Aspects of Enzyme Self-Hydroxylation
J.Biol.Chem., 280, 2005
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8GAE
 | | Hsp90 provides platform for CRaf dephosphorylation by PP5 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ... | | 著者 | Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A. | | 登録日 | 2023-02-22 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Hsp90 provides a platform for kinase dephosphorylation by PP5.
Nat Commun, 14, 2023
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3DZT
 | | AeD7-leukotriene E4 complex | | 分子名称: | (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | | 著者 | Andersen, J.F, Calvo, E, Mans, B.J, Ribeiro, J.M. | | 登録日 | 2008-07-30 | | 公開日 | 2009-02-03 | | 最終更新日 | 2021-03-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Multifunctionality and mechanism of ligand binding in a mosquito antiinflammatory protein
Proc.Natl.Acad.Sci.USA, 106, 2009
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7D66
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3DYE
 | | Crystal structure of AED7-norepineprhine complex | | 分子名称: | BROMIDE ION, D7 protein, GLYCEROL, ... | | 著者 | Andersen, J.F, Calvo, E, Mans, B.J, Ribeiro, J.M. | | 登録日 | 2008-07-27 | | 公開日 | 2009-02-03 | | 最終更新日 | 2021-03-31 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Multifunctionality and mechanism of ligand binding in a mosquito antiinflammatory protein
Proc.Natl.Acad.Sci.USA, 106, 2009
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1JCR
 | | CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE NON-SUBSTRATE TETRAPEPTIDE INHIBITOR CVFM AND FARNESYL DIPHOSPHATE SUBSTRATE | | 分子名称: | ACETIC ACID, FARNESYL DIPHOSPHATE, PROTEIN FARNESYLTRANSFERASE, ... | | 著者 | Long, S.B, Casey, P.J, Beese, L.S. | | 登録日 | 2001-06-11 | | 公開日 | 2001-11-02 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.
Proc.Natl.Acad.Sci.USA, 98, 2001
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4PL2
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3DJP
 | | Bovine Seminal Ribonuclease- Uridine 3' phosphate complex | | 分子名称: | Seminal ribonuclease, URACIL ARABINOSE-3'-PHOSPHATE | | 著者 | Dossi, K, Leonidas, D.D, Zographos, S.E, Oikonomakos, N.G. | | 登録日 | 2008-06-24 | | 公開日 | 2009-06-30 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors
Eur.J.Med.Chem., 44, 2009
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5TGK
 | | Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with dATP | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION | | 著者 | Wang, C, Aleksandrov, A.A, Yang, Z, Forouhar, F, Proctor, E, Kota, P, An, J, Kaplan, A, Khazanov, N, Boel, G, Stockwell, B.R, Senderowitz, H, Dokholyan, N.V, Riordan, J.R, Brouillette, C.G, Hunt, J.F. | | 登録日 | 2016-09-28 | | 公開日 | 2018-05-09 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.912 Å) | | 主引用文献 | Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator.
J. Biol. Chem., 2018
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4J0B
 | | Structure of mitochondrial Hsp90 (TRAP1) with ADP-BeF3 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, COBALT (II) ION, ... | | 著者 | Partridge, J.R, Lavery, L.A, Agard, D.A. | | 登録日 | 2013-01-30 | | 公開日 | 2014-01-22 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.352 Å) | | 主引用文献 | Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
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2XT3
 | | HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF7, MAGNESIUM ION | | 著者 | Klejnot, M, Kozielski, F. | | 登録日 | 2010-10-04 | | 公開日 | 2011-12-14 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.882 Å) | | 主引用文献 | Structural Insights Into Human Kif7, a Kinesin Involved in Hedgehog Signalling.
Acta Crystallogr.,Sect.D, 68, 2012
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1UW7
 | | Nsp9 protein from SARS-coronavirus. | | 分子名称: | NSP9 | | 著者 | Sutton, G, Fry, E, Carter, L, Sainsbury, S, Walter, T, Nettleship, J, Berrow, N, Owens, R, Gilbert, R, Davidson, A, Siddell, S, Poon, L.L.M, Diprose, J, Alderton, D, Walsh, M, Grimes, J.M, Stuart, D.I. | | 登録日 | 2004-01-30 | | 公開日 | 2004-02-20 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The Nsp9 Replicase Protein of Sars-Coronavirus, Structure and Functional Insights
Structure, 12, 2004
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1M4G
 | | Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Ribostamycin | | 分子名称: | 3'-PHOSPHATE-ADENOSINE-5'-DIPHOSPHATE, Aminoglycoside 2'-N-acetyltransferase, COENZYME A, ... | | 著者 | Vetting, M.W, Hegde, S.S, Javid-Majd, F, Blanchard, J.S, Roderick, S.L. | | 登録日 | 2002-07-02 | | 公開日 | 2002-08-28 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates.
Nat.Struct.Biol., 9, 2002
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1URF
 | | HR1b domain from PRK1 | | 分子名称: | PROTEIN KINASE C-LIKE 1 | | 著者 | Owen, D, Lowe, P.N, Nietlispach, D, Brosnan, C.E, Chirgadze, D.Y, Parker, P.J, Blundell, T.L, Mott, H.R. | | 登録日 | 2003-10-29 | | 公開日 | 2003-11-06 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Molecular Dissection of the Interaction between the Small G Proteins Rac1 and Rhoa and Protein Kinase C-Related Kinase 1 (Prk1)
J.Biol.Chem., 278, 2003
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3DJL
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8Q5H
 | | Human KMN network (outer kinetochore) | | 分子名称: | Kinetochore protein Spc24, Kinetochore protein Spc25, Kinetochore scaffold 1, ... | | 著者 | Raisch, T, Polley, S, Vetter, I, Musacchio, A, Raunser, S. | | 登録日 | 2023-08-09 | | 公開日 | 2024-02-14 | | 最終更新日 | 2024-09-04 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Structure of the human KMN complex and implications for regulation of its assembly.
Nat.Struct.Mol.Biol., 31, 2024
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5T1N
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2FDR
 | | Crystal Structure of Conserved Haloacid Dehalogenase-like Protein of Unknown Function ATU0790 from Agrobacterium tumefaciens str. C58 | | 分子名称: | MAGNESIUM ION, conserved hypothetical protein | | 著者 | Nocek, B, Xu, X, Zheng, H, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2005-12-14 | | 公開日 | 2006-01-31 | | 最終更新日 | 2017-10-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of hydrolases/phosphatases-like fold protein
from Agrobacterium tumefaciens str. C58
To be Published
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4Q86
 | | YcaO with AMP Bound | | 分子名称: | ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, Ribosomal protein S12 methylthiotransferase accessory factor YcaO | | 著者 | Chekan, J.R, Nair, S.K. | | 登録日 | 2014-04-25 | | 公開日 | 2014-08-13 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis.
Nat.Chem.Biol., 10, 2014
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