8TS4
 
 | | Crystal structure of T. Brucei hypoxanthine guanine phosphoribosyltransferase in complex with [2S,4S]-4-Guanin-9-yl-2-(2-phosphonoethoxymethyl)-1-N-(3-phosphonopropionyl)pyrrolidine | | 分子名称: | (3-{(2S,4S)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2-phosphonoethoxy)methyl]pyrrolidin-1-yl}-3-oxopropyl)phosphonic acid, Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION | | 著者 | Guddat, L.W, Guddat, L.W. | | 登録日 | 2023-08-10 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design.
J.Med.Chem., 67, 2024
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8TS0
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8TR3
 | | Cryo-EM structure of HmAb64 scFv in complex with CNE40 SOSIP trimer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CNE40 SOSIP Envelope glycoprotein gp120, ... | | 著者 | Chan, K.-W, Kong, X.P. | | 登録日 | 2023-08-09 | | 公開日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.74 Å) | | 主引用文献 | Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains.
Nat Commun, 15, 2024
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8TR1
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8TQX
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8TQP
 | | HIV-CA Disulfide linked Hexamer bound to Quinazolin-4-one Scaffold inhibitor | | 分子名称: | 2-[4-(4-aminobenzene-1-sulfonyl)-2-oxopiperazin-1-yl]-N-{(1R)-2-(3,5-difluorophenyl)-1-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}acetamide, Gag polyprotein | | 著者 | Goldstone, D.C, Barnett, M.J, Taka, J.R.H. | | 登録日 | 2023-08-08 | | 公開日 | 2023-12-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators.
J.Med.Chem., 66, 2023
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8TQE
 | | XptA2 wild type | | 分子名称: | XptA2 | | 著者 | Martin, C.L, Binshtein, E.M, Aller, S.G. | | 登録日 | 2023-08-07 | | 公開日 | 2023-09-27 | | 最終更新日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structures of the Insecticidal Toxin Complex Subunit XptA2 Highlight Roles for Flexible Domains.
Int J Mol Sci, 24, 2023
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8TQD
 | | NF-Kappa-B1 Bound with a Covalent Inhibitor | | 分子名称: | 1-(2-bromo-4-chlorophenyl)-N-{(3S)-1-[(E)-iminomethyl]pyrrolidin-3-yl}methanesulfonamide, Nuclear factor NF-kappa-B p105 subunit | | 著者 | Hilbert, B.J. | | 登録日 | 2023-08-07 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.
Cell, 187, 2024
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8TQA
 | | Crystal structure of Fab.28.14.8 in complex with MHC-I (H2-Db) | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ... | | 著者 | Jiang, J, Boyd, L.F, Natarajan, K, Margulies, D.H. | | 登録日 | 2023-08-06 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Experimental Structures of Antibody/MHC-I Complexes Reveal Details of Epitopes Overlooked by Computational Prediction.
J Immunol., 212, 2024
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8TQ9
 | | Crystal structure of Fab.S19.8 in complex with MHC-I (H2-Dd) | | 分子名称: | Beta-2-microglobulin, Fab.S19.8 Heavy Chain, Fab.S19.8 Light Chain, ... | | 著者 | Jiang, J, Boyd, L.F, Natarajan, K, Margulies, D.H. | | 登録日 | 2023-08-06 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Experimental Structures of Antibody/MHC-I Complexes Reveal Details of Epitopes Overlooked by Computational Prediction.
J Immunol., 212, 2024
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8TQ8
 | | Crystal structure of Fab.34.5.8 in complex with MHC-I (H2-Dd) | | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, Fab.34.5.8 Heavy chain, ... | | 著者 | Jiang, J, Boyd, L.F, Natarajan, K, Margulies, D.H. | | 登録日 | 2023-08-06 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Experimental Structures of Antibody/MHC-I Complexes Reveal Details of Epitopes Overlooked by Computational Prediction.
J Immunol., 212, 2024
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8TQ7
 | | Crystal structure of Fab.34.2.12 in complex with MHC-I (H2-Dd) | | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, Fab 34.2.12 Light Chain, ... | | 著者 | Jiang, J, Boyd, L.F, Natarajan, K, Margulies, D.H. | | 登録日 | 2023-08-06 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Experimental Structures of Antibody/MHC-I Complexes Reveal Details of Epitopes Overlooked by Computational Prediction.
J Immunol., 212, 2024
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8TPI
 | | Synthesis, X-Ray Crystallographic and Biological Activities of Covalent, Non-Peptidic Inhibitors of SARS-CoV-2 Main Protease | | 分子名称: | N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-2-hydroxy-2-methylpropanamide, Non-structural protein 7 | | 著者 | Chua, T.K, Song, Y. | | 登録日 | 2023-08-04 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Design, Synthesis, X-ray Crystallography, and Biological Activities of Covalent, Non-Peptidic Inhibitors of SARS-CoV-2 Main Protease.
Acs Infect Dis., 10, 2024
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8TPF
 | | Synthesis, X-Ray Crystallographic and Biological Activities of Covalent, Non-Peptidic Inhibitors of SARS-CoV-2 Main Protease | | 分子名称: | N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-3-hydroxypropanamide, Non-structural protein 7 | | 著者 | Chua, T.K, Song, Y. | | 登録日 | 2023-08-04 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Design, Synthesis, X-ray Crystallography, and Biological Activities of Covalent, Non-Peptidic Inhibitors of SARS-CoV-2 Main Protease.
Acs Infect Dis., 10, 2024
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8TPE
 | | Synthesis, X-Ray Crystallographic and Biological Activities of Covalent, Non-Peptidic Inhibitors of SARS-CoV-2 Main Protease | | 分子名称: | N-[(1R)-2-(benzylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-N-(4-tert-butylphenyl)-3-hydroxypropanamide, Non-structural protein 7 | | 著者 | Chua, T.K, Song, Y. | | 登録日 | 2023-08-04 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | Design, Synthesis, X-ray Crystallography, and Biological Activities of Covalent, Non-Peptidic Inhibitors of SARS-CoV-2 Main Protease.
Acs Infect Dis., 10, 2024
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8TPA
 | | H1 hemagglutinin (NC99) in complex with medial-junction-targeting Fab 2-2-1G06 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 2-2-1G06, ... | | 著者 | Yang, Y.R, Han, J, Perrett, H.R, Ward, A.B. | | 登録日 | 2023-08-04 | | 公開日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Immune memory shapes human polyclonal antibody responses to H2N2 vaccination.
Biorxiv, 2023
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8TP9
 | | H2 hemagglutinin (A/Singapore/1/1957) in complex with medial-junction-targeting Fab 2-2-1G06 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 2-2-1G06, ... | | 著者 | Yang, Y.R, Han, J, Perrett, H.R, Ward, A.B. | | 登録日 | 2023-08-04 | | 公開日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Immune memory shapes human polyclonal antibody responses to H2N2 vaccination.
Biorxiv, 2023
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8TP7
 | | H2 hemagglutinin (A/Singapore/1/1957) in complex with Sa-targeting Fab 4-1-1G03 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of monoclonal antibody 4-1-1G03, ... | | 著者 | Yang, Y.R, Han, J, Perrett, H.R, Ward, A.B. | | 登録日 | 2023-08-04 | | 公開日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Immune memory shapes human polyclonal antibody responses to H2N2 vaccination.
Biorxiv, 2023
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8TP6
 | | H2 hemagglutinin (A/Singapore/1/1957) in complex with RBS-targeting Fab 4-1-1E02 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 4-1-1E02 Fab, ... | | 著者 | Yang, Y.R, Han, J, Perrett, H.R, Ward, A.B. | | 登録日 | 2023-08-04 | | 公開日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Immune memory shapes human polyclonal antibody responses to H2N2 vaccination.
Biorxiv, 2023
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8TP5
 | | H1 hemagglutinin (NC99) in complex with RBS-targeting Fab 1-1-1E04 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 1-1-1E04, ... | | 著者 | Yang, Y.R, Han, J, Perrett, H.R, Ward, A.B. | | 登録日 | 2023-08-04 | | 公開日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Immune memory shapes human polyclonal antibody responses to H2N2 vaccination.
Biorxiv, 2023
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8TP4
 | | H2 hemagglutinin (A/Singapore/1/1957) in complex with RBS-targeting Fab 1-1-1E04 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 1-1-1E04, ... | | 著者 | Yang, Y.R, Han, J, Perrett, H.R, Ward, A.B. | | 登録日 | 2023-08-04 | | 公開日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Immune memory shapes human polyclonal antibody responses to H2N2 vaccination.
Biorxiv, 2023
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8TP3
 | | H1 hemagglutinin (NC99) in complex with RBS-targeting Fab 1-1-1F05 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 1-1-1F05, ... | | 著者 | Yang, Y.R, Han, J, Perrett, H.R, Ward, A.B. | | 登録日 | 2023-08-04 | | 公開日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Immune memory shapes human polyclonal antibody responses to H2N2 vaccination.
Biorxiv, 2023
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8TP2
 | | H2 hemagglutinin (A/Singapore/1/1957) in complex with RBS-targeting 1-1-1F05 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 1-1-1F05, ... | | 著者 | Yang, Y.R, Han, J, Perrett, H.R, Ward, A.B. | | 登録日 | 2023-08-04 | | 公開日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Immune memory shapes human polyclonal antibody responses to H2N2 vaccination.
Biorxiv, 2023
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8TOV
 | | HIV-CA Disulfide linked Hexamer bound to Quinazolin-4-one Scaffold inhibitor | | 分子名称: | 2-[4-(4-aminobenzene-1-sulfonyl)-2-oxopiperazin-1-yl]-N-[(1R)-2-(3,5-difluorophenyl)-1-{3-[4-(morpholine-4-sulfonyl)phenyl]-4-oxo-3,4-dihydroquinazolin-2-yl}ethyl]acetamide, Matrix protein p17 | | 著者 | Goldstone, D.C, Barnett, M.J, Taka, J.R.H. | | 登録日 | 2023-08-04 | | 公開日 | 2023-12-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators.
J.Med.Chem., 66, 2023
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8TOU
 | | ACE2-peptide 2 complex crystal form 3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | | 著者 | Franck, C, Payne, R.J, Christie, M. | | 登録日 | 2023-08-04 | | 公開日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Discovery of High Affinity Cyclic Peptide Ligands for Human ACE2 with SARS-CoV-2 Entry Inhibitory Activity.
Acs Chem.Biol., 19, 2024
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