8TS4

Crystal structure of T. Brucei hypoxanthine guanine phosphoribosyltransferase in complex with [2S,4S]-4-Guanin-9-yl-2-(2-phosphonoethoxymethyl)-1-N-(3-phosphonopropionyl)pyrrolidine

Summary for 8TS4

Entry DOI	10.2210/pdb8ts4/pdb
Descriptor	Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, (3-{(2S,4S)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2-phosphonoethoxy)methyl]pyrrolidin-1-yl}-3-oxopropyl)phosphonic acid, ... (4 entities in total)
Functional Keywords	inhibitor, complex, purine base, product analog, transferase
Biological source	Trypanosoma brucei
Total number of polymer chains	2
Total formula weight	47823.06
Authors	Guddat, L.W.,Guddat, L.W. (deposition date: 2023-08-10, release date: 2024-05-08)
Primary citation	Keough, D.T.,Petrova, M.,King, G.,Kratochvil, M.,Pohl, R.,Dolezelova, E.,Zikova, A.,Guddat, L.W.,Rejman, D. Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design. J.Med.Chem., 2024 Cited by PubMed: 38651522 DOI: 10.1021/acs.jmedchem.4c00021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation