5LZS
 
 | | Structure of the mammalian ribosomal elongation complex with aminoacyl-tRNA, eEF1A, and didemnin B | | 分子名称: | (2~{S})-~{N}-[(2~{R})-1-[[(3~{S},6~{S},8~{S},12~{S},13~{R},16~{S},17~{R},20~{S},23~{S})-13-[(2~{S})-butan-2-yl]-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-12-oxidanyl-2,5,7,10,15,19,22-heptakis(oxidanylidene)-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-~{N}-methyl-1-[(2~{S})-2-oxidanylpropanoyl]pyrrolidine-2-carboxamide, 18S ribosomal RNA, 28S ribosomal RNA, ... | | 著者 | Shao, S, Murray, J, Brown, A, Taunton, J, Ramakrishnan, V, Hegde, R.S. | | 登録日 | 2016-10-02 | | 公開日 | 2016-11-30 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | | 主引用文献 | Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
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6Z6L
 | | Cryo-EM structure of human CCDC124 bound to 80S ribosomes | | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | | 著者 | Wells, J.N, Buschauer, R, Mackens-Kiani, T, Best, K, Kratzat, H, Berninghausen, O, Becker, T, Cheng, J, Beckmann, R. | | 登録日 | 2020-05-28 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.
Plos Biol., 18, 2020
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8P4A
 | | Structural insights into human co-transcriptional capping - structure 1 | | 分子名称: | DNA (29-MER), DNA (38-MER), DNA-directed RNA polymerase II subunit E, ... | | 著者 | Garg, G, Dienemann, C, Farnung, L, Schwarz, J, Linden, A, Urlaub, H, Cramer, P. | | 登録日 | 2023-05-20 | | 公開日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural insights into human co-transcriptional capping.
Mol.Cell, 83, 2023
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8P4F
 | | Structural insights into human co-transcriptional capping - structure 6 | | 分子名称: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, DNA (38-MER), ... | | 著者 | Garg, G, Dienemann, C, Farnung, L, Schwarz, J, Linden, A, Urlaub, H, Cramer, P. | | 登録日 | 2023-05-20 | | 公開日 | 2023-07-19 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural insights into human co-transcriptional capping.
Mol.Cell, 83, 2023
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5LZW
 | | Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a truncated mRNA. | | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | | 著者 | Shao, S, Murray, J, Brown, A, Taunton, J, Ramakrishnan, V, Hegde, R.S. | | 登録日 | 2016-10-02 | | 公開日 | 2016-11-30 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | | 主引用文献 | Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
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5MS0
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7O80
 | | Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site | | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | | 著者 | Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. | | 登録日 | 2021-04-14 | | 公開日 | 2021-06-02 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
Science, 372, 2021
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8YFQ
 | | Cryo EM structure of Komagataella phaffii RNAPII-Rat1-Rai1 pre-termination complex | | 分子名称: | 5'-3' exoribonuclease, DNA (90-mer), DNA-directed RNA polymerase subunit, ... | | 著者 | Murayama, Y, Yanagisawa, T, Ehara, H, Sekine, S. | | 登録日 | 2024-02-25 | | 公開日 | 2024-09-25 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis of eukaryotic transcription termination by the Rat1 exonuclease complex.
Nat Commun, 15, 2024
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7O81
 | | Rabbit 80S ribosome colliding in another ribosome stalled by the SARS-CoV-2 pseudoknot | | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | | 著者 | Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. | | 登録日 | 2021-04-14 | | 公開日 | 2021-06-02 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
Science, 372, 2021
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7O7Y
 | | Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (high resolution) | | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | | 著者 | Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. | | 登録日 | 2021-04-14 | | 公開日 | 2021-06-02 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | | 主引用文献 | Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
Science, 372, 2021
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7O7Z
 | | Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (classified for pseudoknot) | | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | | 著者 | Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. | | 登録日 | 2021-04-14 | | 公開日 | 2021-06-02 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
Science, 372, 2021
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8YFR
 | | Cryo EM structure of Komagataella phaffii Rat1-Rai1 complex bound within the RNAPII cleft | | 分子名称: | 5'-3' exoribonuclease, DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Murayama, Y, Yanagisawa, T, Ehara, H, Sekine, S. | | 登録日 | 2024-02-25 | | 公開日 | 2024-09-25 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis of eukaryotic transcription termination by the Rat1 exonuclease complex.
Nat Commun, 15, 2024
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5LZY
 | | Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a polyadenylated mRNA. | | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | | 著者 | Shao, S, Murray, J, Brown, A, Taunton, J, Ramakrishnan, V, Hegde, R.S. | | 登録日 | 2016-10-02 | | 公開日 | 2016-11-30 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.99 Å) | | 主引用文献 | Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
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7NWG
 | | Mammalian pre-termination 80S ribosome with Hybrid P/E- and A/P-site tRNA's bound by Blasticidin S. | | 分子名称: | 18S Ribosomal RNA, 28S Ribosomal RNA, 40S ribosomal protein S10, ... | | 著者 | Powers, K.T, Yadav, S.K.N, Bufton, J.C, Schaffitzel, C. | | 登録日 | 2021-03-16 | | 公開日 | 2021-07-07 | | 最終更新日 | 2023-01-11 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Nucleic Acids Res., 49, 2021
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6XZQ
 | | Influenza C virus polymerase in complex with human ANP32A - Subclass 1 | | 分子名称: | Acidic leucine-rich nuclear phosphoprotein 32 family member A, Polymerase acidic protein, Polymerase basic protein 2, ... | | 著者 | Fan, H, Carrique, L, Keown, J.R, Grimes, J.M, Fodor, E. | | 登録日 | 2020-02-05 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Host ANP32A mediates the assembly of the influenza virus replicase.
Nature, 587, 2020
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6X43
 | | Mfd-bound E.coli RNA polymerase elongation complex - II state | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A. | | 登録日 | 2020-05-22 | | 公開日 | 2021-02-03 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural basis for transcription complex disruption by the Mfd translocase.
Elife, 10, 2021
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6PB4
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6PB6
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8QOI
 | | Structure of the human 80S ribosome at 1.9 A resolution - the molecular role of chemical modifications and ions in RNA | | 分子名称: | 18S rRNA (1740-MER), 28S rRNA (3773-MER), 40S ribosomal protein S10, ... | | 著者 | Holvec, S, Barchet, C, Frechin, L, Hazemann, I, von Loeffelholz, O, Klaholz, B.P. | | 登録日 | 2023-09-29 | | 公開日 | 2024-06-12 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (1.9 Å) | | 主引用文献 | The structure of the human 80S ribosome at 1.9 angstrom resolution reveals the molecular role of chemical modifications and ions in RNA.
Nat.Struct.Mol.Biol., 31, 2024
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6PB5
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7OA4
 | | Crystal structure of the N-terminal endonuclease domain of La Crosse virus L-protein bound to compound L-742,001 | | 分子名称: | (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, FORMIC ACID, MANGANESE (II) ION, ... | | 著者 | Feracci, M, Hernandez, S, Vincentelli, R, Ferron, F, Reguera, J, Canard, B, Alvarez, K. | | 登録日 | 2021-04-19 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-09-18 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Biophysical and structural study of La Crosse virus endonuclease inhibition for the development of new antiviral options.
Iucrj, 11, 2024
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6X50
 | | Mfd-bound E.coli RNA polymerase elongation complex - V state | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Llewelyn, E, Chen, J, Kang, J.Y, Darst, S.A. | | 登録日 | 2020-05-24 | | 公開日 | 2021-02-03 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis for transcription complex disruption by the Mfd translocase.
Elife, 10, 2021
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6KLH
 | | Dimeric structure of Machupo virus polymerase bound to vRNA promoter | | 分子名称: | MANGANESE (II) ION, RNA (5'-R(*GP*CP*CP*UP*AP*GP*GP*AP*UP*CP*CP*AP*CP*UP*GP*UP*GP*CP*G)-3'), RNA-directed RNA polymerase L, ... | | 著者 | Peng, R, Xu, X, Jing, J, Peng, Q, Gao, G.F, Shi, Y. | | 登録日 | 2019-07-30 | | 公開日 | 2020-03-18 | | 最終更新日 | 2021-12-08 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural insight into arenavirus replication machinery.
Nature, 579, 2020
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6KLE
 | | Monomeric structure of Machupo virus polymerase bound to vRNA promoter | | 分子名称: | MANGANESE (II) ION, RNA (5'-R(*GP*CP*CP*UP*AP*GP*GP*AP*UP*CP*CP*AP*CP*UP*GP*UP*GP*CP*G)-3'), RNA-directed RNA polymerase L, ... | | 著者 | Peng, R, Xu, X, Jing, J, Peng, Q, Gao, G.F, Shi, Y. | | 登録日 | 2019-07-30 | | 公開日 | 2020-03-18 | | 最終更新日 | 2021-12-08 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Structural insight into arenavirus replication machinery.
Nature, 579, 2020
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6KLC
 | | Structure of apo Lassa virus polymerase | | 分子名称: | MANGANESE (II) ION, RNA-directed RNA polymerase L | | 著者 | Peng, R, Xu, X, Jing, J, Peng, Q, Gao, G.F, Shi, Y. | | 登録日 | 2019-07-30 | | 公開日 | 2020-03-18 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural insight into arenavirus replication machinery.
Nature, 579, 2020
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