PDB: 10243 件ウェブページステータス検索Chemie searchBIRD

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6UU0	E. coli sigma-S transcription initiation complex with a 3-nt RNA and a mismatching GTP ("Fresh" crystal soaked with GTP for 1 hour) 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (3.9 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UU6	E. coli sigma-S transcription initiation complex with a 4-nt RNA and a UTP ("Old" crystal soaked with UTP, ddCTP, and dinucleotide ApG for 30 minutes) 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (4.201 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UU1	E. coli sigma-S transcription initiation complex with a 4-nt RNA and a CTP ("Fresh" crystal soaked with CTP, GTP, and ddTTP for 30 minutes) 分子名称: CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (4.097 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UTZ	E. coli sigma-S transcription initiation complex with a 6-nt RNA ("Fresh" crystal soaked with CTP and UTP for 30 minutes) 分子名称: DIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.803 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UU8	E. coli mutant sigma-S transcription initiation complex with a 7-nt RNA ("Fresh" mutant crystal soaked with GTP, UTP, and CTP for 30 minutes) 分子名称: DIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (4.4 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UU2	E. coli sigma-S transcription initiation complex with 3-nt RNA ("Old" crystal soaked with GTP and ATP for 30 minutes) 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.404 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UU9	E. coli mutant sigma-S transcription initiation complex with an 8-nt RNA ("Fresh" mutant crystal soaked with GTP, UTP, CTP, and ddATP for 30 minutes) 分子名称: 2',3'-DIDEOXYADENOSINE-5'-MONOPHOSPHATE, DIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (5.4 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UU4	E. coli sigma-S transcription initiation complex with a 3-nt RNA ("old" crystal soaked with GTP and dinucleotide GpA for 30 minutes) 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.305 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UTW	E. coli sigma-S transcription initiation complex with a 4-nt RNA ("Fresh" crystal) 分子名称: DIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.854 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UUC	E. coli sigma-S transcription initiation complex with a 3-nt RNA and a mismatching ATP ("Fresh" crystal soaked with ATP for 2 hours) 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.096 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UU7	E. coli sigma-S transcription initiation complex with a 6-nt RNA and an NTP ("Old" crystal soaked with UTP, CTP, ddGTP, and dinucleotide ApG for 30 minutes) 分子名称: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (4.4 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UU5	E. coli sigma-S transcription initiation complex with a 6-nt RNA ("Old" crystal soaked with GTP, UTP, CTP, and dinucleotide GpA for 30 minutes) 分子名称: DIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (5.403 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
7EL9	Structure of Machupo virus L polymerase in complex with Z protein and 3'-vRNA (dimeric complex) 分子名称: MANGANESE (II) ION, Machupo virus 3'-vRNA promoter, RING finger protein Z, ... 著者 Peng, R, Xu, X, Peng, Q, Shi, Y. 登録日 2021-04-09 公開日 2021-05-05 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
7ELA	Structure of Lassa virus polymerase in complex with 3'-vRNA and Z mutant (F36A) 分子名称: 3-'vRNA promoter, MANGANESE (II) ION, RING finger protein Z, ... 著者 Xu, X, Peng, R, Peng, Q, Shi, Y. 登録日 2021-04-09 公開日 2021-05-05 最終更新日 2024-10-16 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
7UIG	Mediator-PIC Early (Mediator A) 分子名称: DNA-directed RNA polymerase II subunit RPB1, Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, ... 著者 Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. 登録日 2022-03-29 公開日 2023-02-15 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structural basis of a transcription pre-initiation complex on a divergent promoter. Mol.Cell, 83, 2023
2O1P	Structure of yeast Poly(A) Polymerase in a somewhat closed state 分子名称: Poly(A) polymerase 著者 Bohm, A, Balbo, P, Toth, J. 登録日 2006-11-29 公開日 2007-01-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 X-ray crystallographic and steady state fluorescence characterization of the protein dynamics of yeast polyadenylate polymerase. J.Mol.Biol., 366, 2007
7ELC	Structure of monomeric complex of MACV L bound to Z and 3'-vRNA 分子名称: 3'-vRNA promoter, MANGANESE (II) ION, RING finger protein Z, ... 著者 Xu, X, Peng, R, Peng, Q, Shi, Y. 登録日 2021-04-09 公開日 2021-05-05 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
5FMZ	Crystal structure of Influenza B polymerase with bound 5' vRNA 分子名称: 5'-R(*AP*GP*UP*AP*GP*UP*AP*AP*CP*AP*AP*GP)-3', POLYMERASE ACIDIC PROTEIN, POLYMERASE BASIC PROTEIN 2, ... 著者 Guilligay, D, Cusack, S. 登録日 2015-11-10 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains. Mol.Cell, 61, 2016
7ED5	A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase 分子名称: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... 著者 Shannon, A, Fattorini, V, Sama, B, Selisko, B, Feracci, M, Falcou, C, Gauffre, P, El Kazzi, P, Delpal, A, Decroly, E, Alvarez, K, Eydoux, C, Guillemot, J.-C, Moussa, A, Good, S, Colla, P, Lin, K, Sommadossi, J.-P, Zhu, Y.X, Yan, X.D, Shi, H, Ferron, F, Canard, B. 登録日 2021-03-15 公開日 2022-02-16 最終更新日 2025-06-25 実験手法 ELECTRON MICROSCOPY (2.98 Å) 主引用文献 A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase. Nat Commun, 13, 2022
6IPJ	Binary Complex of Human DNA Polymerase Mu with MndTTP 分子名称: DNA-directed DNA/RNA polymerase mu,DNA-directed DNA/RNA polymerase mu, MANGANESE (II) ION, SULFATE ION, ... 著者 Chang, Y.K, Wu, W.J, Tsai, M.D. 登録日 2018-11-03 公開日 2019-05-29 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions. J.Am.Chem.Soc., 141, 2019
7ELB	Structure of Machupo virus L polymerase in complex with Z protein (dimeric form) 分子名称: MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... 著者 Peng, R, Xu, X, Peng, Q, Shi, Y. 登録日 2021-04-09 公開日 2021-05-05 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
7BEF	Structures of class II bacterial transcription complexes 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Hao, M, Ye, F.Z, Zhang, X.D. 登録日 2020-12-23 公開日 2021-12-01 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Structures of Class I and Class II Transcription Complexes Reveal the Molecular Basis of RamA-Dependent Transcription Activation. Adv Sci, 9, 2022
6AKH	Pre-catalytic Ternary Complex of Human DNA Polymerase Mu with Templating Adenine and Incoming Mn-dUMPNPP 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Chang, Y.K, Wu, W.J, Tsai, M.D. 登録日 2018-08-31 公開日 2019-05-29 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions. J.Am.Chem.Soc., 141, 2019
4QPX	NV polymerase post-incorporation-like complex 分子名称: GLYCEROL, MANGANESE (II) ION, Polyprotein, ... 著者 Zamyatkin, D.F, Parra, F, Grochulski, P, Ng, K.K.S. 登録日 2014-06-25 公開日 2015-04-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Structure of a backtracked state reveals conformational changes similar to the state following nucleotide incorporation in human norovirus polymerase. Acta Crystallogr.,Sect.D, 70, 2014
6KUU	Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B3) 分子名称: 3'-vRNA, 5'-vRNA, Polymerase 3, ... 著者 Peng, Q, Peng, R, Qi, J, Gao, G.F, Shi, Y. 登録日 2019-09-02 公開日 2019-12-11 最終更新日 2025-06-25 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B3) To Be Published

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