Pre-catalytic Ternary Complex of Human DNA Polymerase Mu with Templating Adenine and Incoming Mn-dUMPNPP

Summary for 6AKH

DescriptorDNA-directed DNA/RNA polymerase mu, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), ... (10 entities in total)
Functional Keywordsdna polymerase mu, dna break repair, transferase-dna complex, transferase/dna
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total molecular weight46450.7
Chang, Y.K.,Wu, W.J.,Tsai, M.D. (deposition date: 2018-08-31, release date: 2019-05-29, Last modification date: 2019-06-12)
Primary citation
Chang, Y.K.,Huang, Y.P.,Liu, X.X.,Ko, T.P.,Bessho, Y.,Kawano, Y.,Maestre-Reyna, M.,Wu, W.J.,Tsai, M.D.
Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.
J.Am.Chem.Soc., 141:8489-8502, 2019
PubMed: 31067051 (PDB entries with the same primary citation)
DOI: 10.1021/jacs.9b01741
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.20110 0.4% 1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report