6AKH
Pre-catalytic Ternary Complex of Human DNA Polymerase Mu with Templating Adenine and Incoming Mn-dUMPNPP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA-directed DNA/RNA polymerase mu | polymer | 356 | 40054.4 | 1 | UniProt (Q9NP87) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) | Homo sapiens (Human) | Pol Mu,Terminal transferase |
| 2 | B (T) | DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3') | polymer | 9 | 2740.8 | 1 | synthetic construct | ||
| 3 | C (P) | DNA (5'-D(*CP*GP*TP*A)-3') | polymer | 4 | 1190.8 | 1 | synthetic construct | ||
| 4 | D (D) | DNA (5'-D(P*GP*CP*CP*G)-3') | polymer | 4 | 1191.8 | 1 | synthetic construct | ||
| 5 | E (A) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 6 | F, G (A) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 7 | H (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 8 | I (A) | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE | non-polymer | 467.2 | 1 | Chemie (DUP) | |||
| 9 | J, K, L, M, N... (A, T) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 10 | Q, R, S, T (A, T, P, D) | water | water | 18.0 | 461 | Chemie (HOH) |
Sequence modifications
A: 132 - 397 (UniProt: Q9NP87)
A: 411 - 494 (UniProt: Q9NP87)
| PDB | External Database | Details |
|---|---|---|
| Gly 127 | - | expression tag |
| Ser 128 | - | expression tag |
| Ala 129 | - | expression tag |
| Ala 130 | - | expression tag |
| Ala 131 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 410 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 45177.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1272.8 | |
| All* | Total formula weight | 46450.7 |
