6ZYM
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![BU of 6zym by Molmil](/molmil-images/mine/6zym) | Human C Complex Spliceosome - High-resolution CORE | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Corepressor interacting with RBPJ 1, ... | 著者 | Bertram, K, Kastner, B. | 登録日 | 2020-08-02 | 公開日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome. Mol.Cell, 80, 2020
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5LYV
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![BU of 5lyv by Molmil](/molmil-images/mine/5lyv) | The crystal structure of 7SK 5'-hairpin - Osmium derivative | 分子名称: | 7SK RNA, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Martinez-Zapien, D, Legrand, P, McEwen, A.G, Pasquali, S, Dock-Bregeon, A.-C. | 登録日 | 2016-09-28 | 公開日 | 2017-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | The crystal structure of the 5 functional domain of the transcription riboregulator 7SK. Nucleic Acids Res., 45, 2017
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6YBW
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![BU of 6ybw by Molmil](/molmil-images/mine/6ybw) | Structure of a human 48S translational initiation complex - 40S body | 分子名称: | 18S rRNA, 40S ribosomal protein S11, 40S ribosomal protein S13, ... | 著者 | Brito Querido, J, Sokabe, M, Kraatz, S, Gordiyenko, Y, Skehel, M, Fraser, C, Ramakrishnan, V. | 登録日 | 2020-03-18 | 公開日 | 2020-09-16 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of a human 48Stranslational initiation complex. Science, 369, 2020
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5VHE
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![BU of 5vhe by Molmil](/molmil-images/mine/5vhe) | DHX36 in complex with the c-Myc G-quadruplex | 分子名称: | DEAH (Asp-Glu-Ala-His) box polypeptide 36, DNA (5'-D(*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*TP*TP*TP*TP*TP*T)-3'), POTASSIUM ION | 著者 | Chen, M, Ferre-D'Amare, A. | 登録日 | 2017-04-13 | 公開日 | 2018-06-13 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.793 Å) | 主引用文献 | Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36. Nature, 558, 2018
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5IFE
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![BU of 5ife by Molmil](/molmil-images/mine/5ife) | Crystal structure of the human SF3b core complex | 分子名称: | PHD finger-like domain-containing protein 5A, POTASSIUM ION, Splicing factor 3B subunit 1, ... | 著者 | Cretu, C, Dybkov, O, De Laurentiis, E, Will, C.L, Luhrmann, R, Pena, V. | 登録日 | 2016-02-25 | 公開日 | 2016-10-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations. Mol.Cell, 64, 2016
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7KTS
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![BU of 7kts by Molmil](/molmil-images/mine/7kts) | Negative stain EM structure of the human SAGA coactivator complex (TRRAP, core, splicing module) | 分子名称: | Ataxin-7, Isoform 3 of Transcription factor SPT20 homolog, STAGA complex 65 subunit gamma, ... | 著者 | Herbst, D.A, Esbin, M.N, Nogales, E. | 登録日 | 2020-11-24 | 公開日 | 2021-11-10 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (19.09 Å) | 主引用文献 | Structure of the human SAGA coactivator complex. Nat.Struct.Mol.Biol., 28, 2021
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8PYR
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![BU of 8pyr by Molmil](/molmil-images/mine/8pyr) | Crystal structure of the dual T-loop phosphorylated Cdk7/CycH/Mat1 complex | 分子名称: | 1,2-ETHANEDIOL, CDK-activating kinase assembly factor MAT1, Cyclin-H, ... | 著者 | Anand, K, Duster, R, Geyer, M. | 登録日 | 2023-07-26 | 公開日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural basis of Cdk7 activation by dual T-loop phosphorylation. Biorxiv, 2024
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5FGO
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6ZWO
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![BU of 6zwo by Molmil](/molmil-images/mine/6zwo) | cryo-EM structure of human mTOR complex 2, focused on one half | 分子名称: | ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T. | 登録日 | 2020-07-28 | 公開日 | 2020-11-18 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | The 3.2- angstrom resolution structure of human mTORC2. Sci Adv, 6, 2020
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6ZWM
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![BU of 6zwm by Molmil](/molmil-images/mine/6zwm) | cryo-EM structure of human mTOR complex 2, overall refinement | 分子名称: | ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T. | 登録日 | 2020-07-28 | 公開日 | 2020-11-18 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | The 3.2- angstrom resolution structure of human mTORC2. Sci Adv, 6, 2020
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6YBS
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![BU of 6ybs by Molmil](/molmil-images/mine/6ybs) | Structure of a human 48S translational initiation complex - head | 分子名称: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S12, ... | 著者 | Brito Querido, J, Sokabe, M, Kraatz, S, Gordiyenko, Y, Skehel, M, Fraser, C, Ramakrishnan, V. | 登録日 | 2020-03-17 | 公開日 | 2020-09-16 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of a human 48Stranslational initiation complex. Science, 369, 2020
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6FT6
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![BU of 6ft6 by Molmil](/molmil-images/mine/6ft6) | Structure of the Nop53 pre-60S particle bound to the exosome nuclear cofactors | 分子名称: | 25S ribosomal RNA, 5S ribosomal RNA, 60S ribosomal protein L11-A, ... | 著者 | Schuller, J.M, Falk, S, Conti, E. | 登録日 | 2018-02-20 | 公開日 | 2018-03-28 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure of the nuclear exosome captured on a maturing preribosome. Science, 360, 2018
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8CX2
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![BU of 8cx2 by Molmil](/molmil-images/mine/8cx2) | Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 2 | 分子名称: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | 著者 | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | 登録日 | 2022-05-19 | 公開日 | 2023-02-15 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | The structural basis for HIV-1 Vif antagonism of human APOBEC3G. Nature, 615, 2023
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8CX0
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![BU of 8cx0 by Molmil](/molmil-images/mine/8cx0) | Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC monomeric complex | 分子名称: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | 著者 | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | 登録日 | 2022-05-19 | 公開日 | 2023-02-15 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | The structural basis for HIV-1 Vif antagonism of human APOBEC3G. Nature, 615, 2023
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8CX1
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![BU of 8cx1 by Molmil](/molmil-images/mine/8cx1) | Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 1 | 分子名称: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | 著者 | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | 登録日 | 2022-05-19 | 公開日 | 2023-02-15 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | The structural basis for HIV-1 Vif antagonism of human APOBEC3G. Nature, 615, 2023
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7KTR
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![BU of 7ktr by Molmil](/molmil-images/mine/7ktr) | Cryo-EM structure of the human SAGA coactivator complex (TRRAP, core) | 分子名称: | Ataxin-7, INOSITOL HEXAKISPHOSPHATE, Isoform 3 of Transcription factor SPT20 homolog, ... | 著者 | Herbst, D.A, Esbin, M.N, Nogales, E. | 登録日 | 2020-11-24 | 公開日 | 2021-11-10 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | Structure of the human SAGA coactivator complex. Nat.Struct.Mol.Biol., 28, 2021
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8QU8
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![BU of 8qu8 by Molmil](/molmil-images/mine/8qu8) | PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1 | 分子名称: | (2S,4R)-1-[(2S)-2-[4-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2,3-triazol-1-yl]-3-methyl-butanoyl]-N-[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-oxidanyl-ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | 著者 | Fischer, G, Peter, D, Arce-Solano, S. | 登録日 | 2023-10-14 | 公開日 | 2023-12-06 | 最終更新日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Targeting cancer with small molecule pan-KRAS degraders Biorxiv, 2023
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6YWN
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![BU of 6ywn by Molmil](/molmil-images/mine/6ywn) | CutA in complex with CMPCPP | 分子名称: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, CALCIUM ION, CutA | 著者 | Malik, D, Kobylecki, K, Krawczyk, P, Poznanski, J, Jakielaszek, A, Napiorkowska, A, Dziembowski, A, Tomecki, R, Nowotny, M. | 登録日 | 2020-04-29 | 公開日 | 2020-08-05 | 最終更新日 | 2020-09-30 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structure and mechanism of CutA, RNA nucleotidyl transferase with an unusual preference for cytosine. Nucleic Acids Res., 48, 2020
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3LK9
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![BU of 3lk9 by Molmil](/molmil-images/mine/3lk9) | DNA polymerase beta with a gapped DNA substrate and dTMP(CF2)P(CF2)P | 分子名称: | 5'-O-[(R)-{[(R)-[difluoro(phosphono)methyl](hydroxy)phosphoryl](difluoro)methyl}(hydroxy)phosphoryl]thymidine, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... | 著者 | Zibinsky, M, Surya Prakash, G.K, Upton, T.G, Kashemirov, B.A, McKenna, C.E, Oertell, K, Goodman, M.F, Batra, V.K, Pedersen, L.C, Beard, W.A, Wilson, S.H. | 登録日 | 2010-01-27 | 公開日 | 2011-01-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. Proc.Natl.Acad.Sci.USA, 107, 2010
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1QJX
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![BU of 1qjx by Molmil](/molmil-images/mine/1qjx) | HUMAN RHINOVIRUS 16 COAT PROTEIN IN COMPLEX WITH ANTIVIRAL COMPOUND WIN68934 | 分子名称: | 2,6-DIMETHYL-1-(3-[3-METHYL-5-ISOXAZOLYL]-PROPANYL)-4-[4-METHYL-2H-TETRAZOL-2-YL]-PHENOL, MYRISTIC ACID, PROTEIN VP1, ... | 著者 | Hadfield, A.T, Diana, G.D, Rossmann, M.G. | 登録日 | 1999-07-06 | 公開日 | 1999-07-20 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Analysis of Three Structurally Related Antiviral Compounds in Complex with Human Rhinovirus 16 Proc.Natl.Acad.Sci.USA, 96, 1999
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7LSG
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![BU of 7lsg by Molmil](/molmil-images/mine/7lsg) | |
2JV6
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![BU of 2jv6 by Molmil](/molmil-images/mine/2jv6) | YF ED3 Protein NMR Structure | 分子名称: | Envelope protein E | 著者 | Volk, D.E, Gandham, S.H.A, May, F.J, Anderson, A, Barrett, A.D.T, Gorenstein, D.G. | 登録日 | 2007-09-12 | 公開日 | 2008-09-16 | 最終更新日 | 2022-03-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Yellow Fever Virus Envelope Protein Domain III: A Convergence of Structure and Phylogenetics To be Published
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8FY2
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![BU of 8fy2 by Molmil](/molmil-images/mine/8fy2) | E3:PROTAC:target ternary complex structure (VCB/WH244/BCL-2) | 分子名称: | Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... | 著者 | Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Ruben, E, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. | 登録日 | 2023-01-25 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
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8FY1
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![BU of 8fy1 by Molmil](/molmil-images/mine/8fy1) | E3:PROTAC:target ternary complex structure (VCB/753b/BCL-2) | 分子名称: | Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... | 著者 | Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. | 登録日 | 2023-01-25 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
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8FY0
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![BU of 8fy0 by Molmil](/molmil-images/mine/8fy0) | E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL) | 分子名称: | Bcl-2-like protein 1, CACODYLIC ACID, Elongin-B, ... | 著者 | Olsen, S.K, Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D. | 登録日 | 2023-01-25 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
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