4JJN
| Crystal structure of heterochromatin protein Sir3 in complex with a silenced yeast nucleosome | 分子名称: | DNA (146-MER), Histone H2A.2, Histone H2B.2, ... | 著者 | Wang, F, Li, G, Mohammed, A, Lu, C, Currie, M, Johnson, A, Moazed, D. | 登録日 | 2013-03-08 | 公開日 | 2013-05-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | Heterochromatin protein Sir3 induces contacts between the amino terminus of histone H4 and nucleosomal DNA. Proc.Natl.Acad.Sci.USA, 110, 2013
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4RAC
| Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents | 分子名称: | Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, [(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)methyl]phosphonic acid | 著者 | Keough, D.T, Hockova, D, Janeba, Z, Wang, T.-H, Naesens, L, Edstein, M.D, Chavchich, M, Guddat, L.W. | 登録日 | 2014-09-10 | 公開日 | 2015-01-07 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents. J.Med.Chem., 58, 2015
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4RAN
| Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents | 分子名称: | (2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](3-aminopropyl)amino}ethyl)phosphonic acid, Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION | 著者 | Keough, D.T, Hockova, D, Janeba, Z, Wang, T.-H, Naesens, L, Edstein, M.D, Chavchich, M, Guddat, L.W. | 登録日 | 2014-09-10 | 公開日 | 2015-01-07 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.549 Å) | 主引用文献 | Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents. J.Med.Chem., 58, 2015
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3D1V
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5L2A
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8TOF
| Rpd3S bound to an H3K36Cme3 modified nucleosome | 分子名称: | Chromatin modification-related protein EAF3, DNA (176-MER), Histone H2A, ... | 著者 | Markert, J.W, Vos, S.M, Farnung, L. | 登録日 | 2023-08-03 | 公開日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structure of the complete Saccharomyces cerevisiae Rpd3S-nucleosome complex. Nat Commun, 14, 2023
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6TEM
| CENP-A nucleosome core particle with 145 base pairs of the Widom 601 sequence by cryo-EM | 分子名称: | Histone H2A, Histone H2B 1.1, Histone H3-like centromeric protein A, ... | 著者 | Boopathi, R, Danev, R, Petosa, C, Bednar, J. | 登録日 | 2019-11-12 | 公開日 | 2020-04-08 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Phase-plate cryo-EM structure of the Widom 601 CENP-A nucleosome core particle reveals differential flexibility of the DNA ends. Nucleic Acids Res., 48, 2020
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1YBF
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2Z83
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8SYP
| Genomic CX3CR1 nucleosome | 分子名称: | DNA (162-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | 著者 | Lian, T, Guan, R, Bai, Y. | 登録日 | 2023-05-25 | 公開日 | 2023-11-01 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBP alpha. Nat.Struct.Mol.Biol., 31, 2024
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7WLP
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7VBM
| The mouse nucleosome structure containing H3mm18 aided by PL2-6 scFv | 分子名称: | DNA (126-MER), Histone H2A type 1-B, Histone H2B type 3-A, ... | 著者 | Hirai, S, Takizawa, Y, Kujirai, T, Kurumizaka, H. | 登録日 | 2021-08-31 | 公開日 | 2022-01-19 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Unusual nucleosome formation and transcriptome influence by the histone H3mm18 variant. Nucleic Acids Res., 50, 2022
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7ZUN
| Crystal structure of PIM1 in complex with a Pyrrolo-Pyrazinone compound | 分子名称: | (4~{S})-4-(2-azanylethyl)-6-phenyl-7-[3-(trifluoromethyloxy)phenyl]-3,4-dihydropyrrolo[1,2-a]pyrazin-1-ol, Isoform 2 of Serine/threonine-protein kinase pim-1 | 著者 | Casale, E. | 登録日 | 2022-05-12 | 公開日 | 2022-10-05 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Stereoselective synthesis of 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as PIM kinase inhibitors inspired from marine alkaloids. Chirality, 34, 2022
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5LF8
| Human Nucleoside diphosphate-linked moiety X motif 17 (NUDT17) | 分子名称: | ETHYL MERCURY ION, Nucleoside diphosphate-linked moiety X motif 17, PHOSPHATE ION | 著者 | Mathea, S, Tallant, C, Salah, E, Wang, D, Velupillai, S, Nowak, R, Oerum, S, Krojer, T, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Huber, K, Structural Genomics Consortium (SGC) | 登録日 | 2016-06-30 | 公開日 | 2017-08-16 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Human Nucleoside diphosphate-linked moiety X motif 17 (NUDT17) To Be Published
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3TFS
| Ternary complex structure of DNA polymerase beta with a gapped DNA substrate and a, b dAMP(CFH)PP in the active site: Stereoselective binding of (S) isomer | 分子名称: | 2'-deoxy-5'-O-[(S)-{(S)-fluoro[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]adenosine, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*TP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... | 著者 | Chamberlain, B.T, Batra, V.K, Beard, W.A, Kadina, A.P, Shock, D.D, Kashemirov, B.A, McKenna, C.E, Goodman, M.F, Wilson, S.H. | 登録日 | 2011-08-16 | 公開日 | 2012-03-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Stereospecific Formation of a Ternary Complex of (S)-alpha, beta-Fluoromethylene-dATP with DNA Pol beta. Chembiochem, 13, 2012
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2HVD
| Human nucleoside diphosphate kinase A complexed with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Nucleoside diphosphate kinase A | 著者 | Giraud, M.-F, Georgescauld, F, Lascu, I, Dautant, A. | 登録日 | 2006-07-28 | 公開日 | 2006-09-19 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Crystal Structures of S120G Mutant and Wild Type of Human Nucleoside Diphosphate Kinase A in Complex with ADP J.Bioenerg.Biomembr., 38, 2006
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2HVE
| S120G mutant of human nucleoside diphosphate kinase A complexed with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Nucleoside diphosphate kinase A | 著者 | Giraud, M.-F, Georgescauld, F, Lascu, I, Dautant, A. | 登録日 | 2006-07-28 | 公開日 | 2006-09-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.402 Å) | 主引用文献 | Crystal Structures of S120G Mutant and Wild Type of Human Nucleoside Diphosphate Kinase A in Complex with ADP J.Bioenerg.Biomembr., 38, 2006
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8V25
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8V28
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8V26
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8V27
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7DBH
| The mouse nucleosome structure containing H3mm18 | 分子名称: | DNA (126-MER), Histone H2A type 1-B, Histone H2B type 3-A, ... | 著者 | Hirai, S, Takizawa, Y, Kujirai, T, Kurumizaka, H. | 登録日 | 2020-10-20 | 公開日 | 2022-01-19 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Unusual nucleosome formation and transcriptome influence by the histone H3mm18 variant. Nucleic Acids Res., 50, 2022
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6YTM
| Human Brd2(BD2) L383V mutant in complex with ET-JQ1-OMe | 分子名称: | (2S)-1-[3-{[(2R)-2-hydroxypropyl]oxy}-2,2-bis({[(2R)-2-hydroxypropyl]oxy}methyl)propoxy]propan-2-ol, Bromodomain-containing protein 2, methyl (2R)-2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]butanoate | 著者 | Bond, A.G, Ciulli, A, Cowan, A.D. | 登録日 | 2020-04-24 | 公開日 | 2020-05-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Stereoselective synthesis of allele-specific BET inhibitors. Org.Biomol.Chem., 18, 2020
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7D69
| Cryo-EM structure of the nucleosome containing Giardia histones | 分子名称: | 601L DNA (145-MER), Histone H2A, Histone H2B, ... | 著者 | Sato, S, Takizawa, Y, Kurumizaka, H. | 登録日 | 2020-09-29 | 公開日 | 2021-09-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | 主引用文献 | Cryo-EM structure of the nucleosome core particle containing Giardia lamblia histones. Nucleic Acids Res., 49, 2021
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4OGF
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