7ZUN
Crystal structure of PIM1 in complex with a Pyrrolo-Pyrazinone compound
Summary for 7ZUN
Entry DOI | 10.2210/pdb7zun/pdb |
Descriptor | Isoform 2 of Serine/threonine-protein kinase pim-1, (4~{S})-4-(2-azanylethyl)-6-phenyl-7-[3-(trifluoromethyloxy)phenyl]-3,4-dihydropyrrolo[1,2-a]pyrazin-1-ol (3 entities in total) |
Functional Keywords | pim1, atp binding, kinase inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 36251.10 |
Authors | Casale, E. (deposition date: 2022-05-12, release date: 2022-10-05, Last modification date: 2024-01-31) |
Primary citation | Casuscelli, F.,Ardini, E.,Avanzi, N.,Badari, A.,Casale, E.,Disingrini, T.,Donati, D.,Ermoli, A.,Felder, E.R.,Galvani, A.,Isacchi, A.,Menichincheri, M.,Montemartini, M.,Orrenius, C.,Piutti, C.,Salom, B.,Papeo, G. Stereoselective synthesis of 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as PIM kinase inhibitors inspired from marine alkaloids. Chirality, 34:1437-1452, 2022 Cited by PubMed: 35959859DOI: 10.1002/chir.23501 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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