6YTM
Human Brd2(BD2) L383V mutant in complex with ET-JQ1-OMe
Summary for 6YTM
Entry DOI | 10.2210/pdb6ytm/pdb |
Descriptor | Bromodomain-containing protein 2, methyl (2R)-2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]butanoate, (2S)-1-[3-{[(2R)-2-hydroxypropyl]oxy}-2,2-bis({[(2R)-2-hydroxypropyl]oxy}methyl)propoxy]propan-2-ol, ... (4 entities in total) |
Functional Keywords | epigenetics, bump and hole, brd2, second bromodomain, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 28345.62 |
Authors | Bond, A.G.,Ciulli, A.,Cowan, A.D. (deposition date: 2020-04-24, release date: 2020-05-27, Last modification date: 2024-01-24) |
Primary citation | Bond, A.G.,Testa, A.,Ciulli, A. Stereoselective synthesis of allele-specific BET inhibitors. Org.Biomol.Chem., 18:7533-7539, 2020 Cited by PubMed: 32756710DOI: 10.1039/d0ob01165g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.56 Å) |
Structure validation
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