6YTM

Human Brd2(BD2) L383V mutant in complex with ET-JQ1-OMe

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Bromodomain-containing protein 2	polymer	114	13361.4	2	UniProt (P25440) Pfam (PF00439) In PDB	Homo sapiens (Human)	O27.1.1,Really interesting new gene 3 protein
2	A, B	methyl (2R)-2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]butanoate	non-polymer		443.0	2	Chemie (PMW)
3	A	(2S)-1-[3-{[(2R)-2-hydroxypropyl]oxy}-2,2-bis({[(2R)-2-hydroxypropyl]oxy}methyl)propoxy]propan-2-ol	non-polymer		368.5	2	Chemie (PXN)
4		water	water		18.0	186	Chemie (HOH)

Sequence modifications

A, B: 345 - 455 (UniProt: P25440)

PDB	External Database	Details
Ser 342	-	expression tag
Met 343	-	expression tag
Gly 344	-	expression tag
Val 383	Leu 383	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	26722.8
Non-Polymers*	Number of molecules	4
	Total formula weight	1622.8
All*	Total formula weight	28345.6

*Water molecules are not included.