3D1V

Crystal structure of human PNP complexed with 2-mercapto(3H) quinazolinone

Summary for 3D1V

Entry DOI	10.2210/pdb3d1v/pdb
Related	1m73 1pf7
Descriptor	Purine nucleoside phosphorylase, SULFATE ION, 2-mercapto(3H)quinazolinone, ... (4 entities in total)
Functional Keywords	purine nucleoside phosphorylase, drug design, synchrotron, empirical scoring function, 2-mercapto-4(3h) quinazolinone, acetylation, disease mutation, glycosyltransferase, polymorphism, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytoskeleton (By similarity): P00491
Total number of polymer chains	1
Total formula weight	32651.28
Authors	De Azevedo Jr., W.F.,Basso, L.A.,Santos, D.S. (deposition date: 2008-05-06, release date: 2009-07-14, Last modification date: 2023-08-30)
Primary citation	Timmers, L.F.,Caceres, R.A.,Vivan, A.L.,Gava, L.M.,Dias, R.,Ducati, R.G.,Basso, L.A.,Santos, D.S.,de Azevedo, W.F. Structural studies of human purine nucleoside phosphorylase: towards a new specific empirical scoring function Arch.Biochem.Biophys., 479:28-38, 2008 Cited by PubMed: 18790691 DOI: 10.1016/j.abb.2008.08.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation