PDB: 45953 件ウェブページステータス検索Chemie searchBIRD

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2M93	Structure of d[TTGGGTGGGCGCGAAGCATTCGCGGGGTGGGT] quadruplex-duplex hybrid 分子名称: 32-MER DNA 著者 Lim, K.W, Phan, A.T. 登録日 2013-05-30 公開日 2013-07-10 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural basis of DNA quadruplex-duplex junction formation. Angew.Chem.Int.Ed.Engl., 52, 2013
8U4W	The crystal structure of a helical domain deleted PARP1 in complex with isoindolinone based inhibitor. 分子名称: (4M)-4-(2-{4-[(3S)-1-acetylpiperidine-3-carbonyl]piperazine-1-carbonyl}-1-benzofuran-7-yl)-1H-isoindol-1-one, Poly [ADP-ribose] polymerase 1, processed C-terminus 著者 Marcotte, D.J. 登録日 2023-09-11 公開日 2024-03-27 最終更新日 2024-06-26 実験手法 X-RAY DIFFRACTION (3.02 Å) 主引用文献 Discovery of Potent Isoindolinone Inhibitors that Target an Active Conformation of PARP1 Using DNA-Encoded Libraries. Chemmedchem, 19, 2024
6BZG	Structure of S. cerevisiae Zip2:Spo16 complex, P212121 form 分子名称: HEXAETHYLENE GLYCOL, Protein ZIP2, SULFATE ION, ... 著者 Arora, K, Corbett, K.D. 登録日 2017-12-23 公開日 2018-02-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 The conserved XPF:ERCC1-like Zip2:Spo16 complex controls meiotic crossover formation through structure-specific DNA binding. Nucleic Acids Res., 47, 2019
5VAJ	BhRNase H - amide-RNA/DNA complex 分子名称: ACETATE ION, DNA (5'-D(*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*C)-3'), GLYCEROL, ... 著者 Pallan, P.S, Egli, M. 登録日 2017-03-27 公開日 2017-09-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs. Nucleic Acids Res., 45, 2017
5A78	Crystal structure of the homing endonuclease I-CvuI in complex with I- CreI target (C1221) in the presence of 2 mM Mg revealing DNA not cleaved 分子名称: 24MER DNA, 5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP *CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3', DNA ENDONUCLEASE I-CVUI, ... 著者 Molina, R, Redondo, P, LopezMendez, B, Villate, M, Merino, N, Blanco, F.J, Valton, J, Grizot, S, Duchateau, P, Prieto, J, Montoya, G. 登録日 2015-07-03 公開日 2015-09-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification J.Biol.Chem., 290, 2015
5YZY	AtVAL1 B3 domain in complex with 13bp-DNA 分子名称: B3 domain-containing transcription repressor VAL1, DNA (5'-D(*AP*TP*TP*CP*TP*GP*CP*AP*TP*GP*GP*AP*T)-3'), DNA (5'-D(*TP*AP*TP*CP*CP*AP*TP*GP*CP*AP*GP*AP*A)-3'), ... 著者 Wu, B.X, Zhang, M.M. 登録日 2017-12-17 公開日 2018-05-02 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Structural insight into the role of VAL1 B3 domain for targeting to FLC locus in Arabidopsis thaliana. Biochem. Biophys. Res. Commun., 2018
2IH5	Crystal structure of the adenine-specific DNA methyltransferase M.TaqI complexed with the cofactor analog AETA and a 10 bp DNA containing an abasic site analog at the target base partner position 分子名称: 5'-D(*GP*AP*CP*AP*(3DR)P*CP*GP*(6MA)P*AP*C)-3', 5'-D(*GP*TP*TP*CP*GP*AP*TP*GP*TP*C)-3', 5'-DEOXY-5'-[2-(AMINO)ETHYLTHIO]ADENOSINE, ... 著者 Lenz, T, Scheidig, A.J, Weinhold, E. 登録日 2006-09-25 公開日 2007-11-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Influence of the target base partner on the methylation rate of the adenine-specific DNA methyltransferase M.TaqI To be Published
7OT6	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND inhibitor RMC-282 分子名称: (R)-N-(1-(6-amino-9H-purin-9-yl)propan-2-yl)-N-(2-phosphonoethyl)glycine, DNA (5'-D(*AP*TP*GP*GP*AP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)*CP*GP*CP*CP*(DDG))-3'), ... 著者 Martinez, S.E, Singh, A.K, Gu, W, Das, K. 登録日 2021-06-09 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design. Eur.J.Med.Chem., 225, 2021
7OTX	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-257 分子名称: (S)-2-((3-(6-amino-9H-purin-9-yl)propyl)amino)-3-phosphonopropanoic acid, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), ... 著者 Martinez, S.E, Singh, A.K, Gu, W, Das, K. 登録日 2021-06-10 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design. Eur.J.Med.Chem., 225, 2021
7OUT	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-264 分子名称: (S)-2-(3-(6-amino-9H-purin-9-yl)propoxy)-3-phosphonopropanoic acid, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), ... 著者 Martinez, S.E, Singh, A.K, Gu, W, Das, K. 登録日 2021-06-13 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design. Eur.J.Med.Chem., 225, 2021
7OTK	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-233 分子名称: (2~{R})-2-[2-(6-aminopurin-9-yl)ethylamino]-3-phosphono-propanoic acid, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), ... 著者 Martinez, S.E, Singh, A.K, Gu, W, Das, K. 登録日 2021-06-10 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design. Eur.J.Med.Chem., 225, 2021
7OTA	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-230 分子名称: ((2-(6-amino-9H-purin-9-yl)ethyl)-L-seryl)phosphoramidic acid, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), ... 著者 Martinez, S.E, Singh, A.K, Gu, W, Das, K. 登録日 2021-06-09 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design. Eur.J.Med.Chem., 225, 2021
6BZF	Structure of S. cerevisiae Zip2:Spo16 complex, C2 form 分子名称: Protein ZIP2, Sporulation-specific protein 16 著者 Arora, K, Corbett, K.D. 登録日 2017-12-23 公開日 2018-02-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.286 Å) 主引用文献 The conserved XPF:ERCC1-like Zip2:Spo16 complex controls meiotic crossover formation through structure-specific DNA binding. Nucleic Acids Res., 47, 2019
1RYU	Solution Structure of the SWI1 ARID 分子名称: SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1 著者 Kim, S, Zhang, Z, Upchurch, S, Isern, N, Chen, Y. 登録日 2003-12-22 公開日 2004-05-25 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structure and DNA-binding sites of the SWI1 AT-rich interaction domain (ARID) suggest determinants for sequence-specific DNA recognition. J.Biol.Chem., 279, 2004
7OTN	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-247 分子名称: (S)-2-((2-(6-amino-9H-purin-9-yl)ethyl)amino)-3-phosphonopropanoic acid, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), ... 著者 Martinez, S.E, Singh, A.K, Gu, W, Das, K. 登録日 2021-06-10 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design. Eur.J.Med.Chem., 225, 2021
7OTZ	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-259 分子名称: (S)-2-(2-(6-amino-9H-purin-9-yl)ethoxy)-3-phosphonopropanoic acid, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), ... 著者 Martinez, S.E, Singh, A.K, Gu, W, Das, K. 登録日 2021-06-10 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design. Eur.J.Med.Chem., 225, 2021
1S7E	Solution structure of HNF-6 分子名称: Hepatocyte nuclear factor 6 著者 Liao, X, Sheng, W. 登録日 2004-01-29 公開日 2004-12-28 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structure of the hepatocyte nuclear factor 6alpha and its interaction with DNA. J.Biol.Chem., 279, 2004
7O0N	Crystal structure of a ParB E93A mutant from Myxococcus xanthus bound to CDP and monothiophosphate 分子名称: CYTIDINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Altegoer, F, Bange, G. 登録日 2021-03-26 公開日 2021-09-15 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 The CTPase activity of ParB determines the size and dynamics of prokaryotic DNA partition complexes. Mol.Cell, 81, 2021
6BHV	Human PARP-1 bound to NAD+ analog benzamide adenine dinucleotide (BAD) 分子名称: Poly [ADP-ribose] polymerase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4R,5S)-5-(3-carbamoylphenyl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name) 著者 Pascal, J.M, Langelier, M.F. 登録日 2017-10-31 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 NAD+analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains. Nat Commun, 9, 2018
4M32	Crystal structure of gated-pore mutant D138N of second DNA-Binding protein under starvation from Mycobacterium smegmatis 分子名称: CHLORIDE ION, FE (II) ION, MAGNESIUM ION, ... 著者 Williams, S.M, Chandran, A.V, Vijayabaskar, M.S, Roy, S, Balaram, H, Vishveshwara, S, Vijayan, M, Chatterji, D. 登録日 2013-08-06 公開日 2014-03-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 A histidine aspartate ionic lock gates the iron passage in miniferritins from Mycobacterium smegmatis J.Biol.Chem., 289, 2014
6C5D	N-terminal domain of Helicobacter pylori LlaJI.R1 分子名称: LlaJI.R1 著者 Hosford, C.J, Chappie, J.S. 登録日 2018-01-16 公開日 2018-06-27 最終更新日 2018-08-08 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 The crystal structure of theHelicobacter pyloriLlaJI.R1 N-terminal domain provides a model for site-specific DNA binding. J. Biol. Chem., 293, 2018
8KAG	Crystal structure of SpyCas9 in complex with sgRNA and target RNA 分子名称: CRISPR-associated endonuclease Cas9/Csn1, RNA (5'-R(*CP*CP*AP*CP*UP*UP*CP*AP*AP*UP*UP*AP*GP*AP*AP*CP*AP*CP*GP*GP*AP*CP*C)-3'), RNA (98-MER) 著者 Chen, Y, Chen, J, Liu, L. 登録日 2023-08-03 公開日 2024-06-05 最終更新日 2024-06-12 実験手法 X-RAY DIFFRACTION (3.88 Å) 主引用文献 Trans-nuclease activity of Cas9 activated by DNA or RNA target binding. Nat.Biotechnol., 2024
3M7K	Crystal structure of PacI-DNA Enzyme product complex 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*TP*TP*AP*AP*T)-3'), DNA (5'-D(P*TP*AP*AP*GP*CP*CP*TP*C)-3'), ... 著者 Shen, B.W, Stoddard, B.L. 登録日 2010-03-16 公開日 2010-04-21 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Unusual target site disruption by the rare-cutting HNH restriction endonuclease PacI. Structure, 18, 2010
5YZZ	AtVAL1 B3 domain in complex with 13bp-DNA 分子名称: B3 domain-containing transcription repressor VAL1, DNA (5'-D(*AP*TP*TP*CP*TP*GP*CP*AP*TP*GP*GP*AP*T)-3'), DNA (5'-D(*TP*AP*TP*CP*CP*AP*TP*GP*CP*AP*GP*AP*A)-3') 著者 Wu, B.X, Zhang, M.M. 登録日 2017-12-17 公開日 2018-05-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Structural insight into the role of VAL1 B3 domain for targeting to FLC locus in Arabidopsis thaliana. Biochem. Biophys. Res. Commun., 2018
4M94	d(ATCCGTTATAACGGAT) complexed with Moloney Murine Leukemia virus reverse transcriptase catalytic fragment 分子名称: 1,2-ETHANEDIOL, 5' d(ATCCGttA) 3', 5' d(TAACGGAT) 3', ... 著者 Singh, I. 登録日 2013-08-14 公開日 2014-03-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognition. Acta Crystallogr.,Sect.D, 70, 2014

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