5VAJ
BhRNase H - amide-RNA/DNA complex
Summary for 5VAJ
Entry DOI | 10.2210/pdb5vaj/pdb |
Descriptor | RNA (5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*(URU)P*C)-3'), DNA (5'-D(*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*C)-3'), Ribonuclease H, ... (7 entities in total) |
Functional Keywords | amide-rna, sirna, rna x-ray structure, phosphate modification, ribonuclease h, amide modified rna-dna., hydrolase-rna-dna complex, hydrolase/rna/dna |
Biological source | Bacillus halodurans More |
Total number of polymer chains | 4 |
Total formula weight | 41197.95 |
Authors | Pallan, P.S.,Egli, M. (deposition date: 2017-03-27, release date: 2017-09-13, Last modification date: 2023-10-04) |
Primary citation | Mutisya, D.,Hardcastle, T.,Cheruiyot, S.K.,Pallan, P.S.,Kennedy, S.D.,Egli, M.,Kelley, M.L.,Smith, A.V.B.,Rozners, E. Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs. Nucleic Acids Res., 45:8142-8155, 2017 Cited by PubMed: 28854734DOI: 10.1093/nar/gkx558 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
Download full validation report