PDB: 1334 件ウェブページステータス検索Chemie searchBIRD

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3M04	Carbonic Anhydrase II in complex with novel sulfonamide inhibitor 分子名称: (4-CARBOXYPHENYL)(CHLORO)MERCURY, Carbonic anhydrase 2, ZINC ION, ... 著者 Schulze Wischeler, J, Heine, A, Klebe, G, Sandner, N.U. 登録日 2010-03-02 公開日 2011-05-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structural investigation and inhibitor studies on Carbonic Anhydrase II To be Published
3LXE	Human Carbonic Anhydrase I in complex with topiramate 分子名称: Carbonic anhydrase 1, ZINC ION, [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate 著者 Alterio, V, De Simone, G, Monti, S.M, Truppo, E. 登録日 2010-02-25 公開日 2010-07-21 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: the carbonic anhydrase I-topiramate complex. Org.Biomol.Chem., 2010
3L14	Human Carbonic Anhydrase II complexed with Althiazide 分子名称: 4-AMINO-6-CHLOROBENZENE-1,3-DISULFONAMIDE, Carbonic anhydrase 2, ZINC ION 著者 Quirit, J.G, Robbins, A, Genis, C, Tu, C, Silverman, D.N, McKenna, R. 登録日 2009-12-10 公開日 2011-01-05 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.22 Å) 主引用文献 The Promiscuous Nature of Althiazide in Adducts with CA II and CA IX Mimic To be Published
3KWA	Polyamines inhibit carbonic anhydrases 分子名称: Carbonic anhydrase 2, MERCURY (II) ION, SPERMINE, ... 著者 Temperini, C. 登録日 2009-12-01 公開日 2010-07-14 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule J.Med.Chem., 53, 2010
3KS3	High resolution structure of Human Carbonic Anhydrase II at 0.9 A 分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION 著者 Avvaru, B.S. 登録日 2009-11-20 公開日 2010-01-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (0.9 Å) 主引用文献 A short, strong hydrogen bond in the active site of human carbonic anhydrase II. Biochemistry, 49, 2010
3KON	Crystal structure of cobalt (II) human carbonic anhydrase II at pH 11.0 分子名称: COBALT (II) ION, Carbonic anhydrase 2 著者 Avvaru, B.S. 登録日 2009-11-13 公開日 2010-08-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Comparison of solution and crystal properties of Co(II)-substituted human carbonic anhydrase II. Arch.Biochem.Biophys., 502, 2010
3KOK	Crystal structure of cobalt (II) human carbonic anhydrase II at pH 8.5 分子名称: COBALT (II) ION, Carbonic anhydrase 2 著者 Avvaru, B.S. 登録日 2009-11-13 公開日 2010-08-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Comparison of solution and crystal properties of Co(II)-substituted human carbonic anhydrase II. Arch.Biochem.Biophys., 502, 2010
3KOI	Crystal structure of cobalt (III) human carbonic anhydrase II at pH 6.0 分子名称: COBALT (III) ION, Carbonic anhydrase 2 著者 Avvaru, B.S. 登録日 2009-11-13 公開日 2010-08-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Comparison of solution and crystal properties of Co(II)-substituted human carbonic anhydrase II. Arch.Biochem.Biophys., 502, 2010
3KNE	Carbonic Anhydrase II H64C mutant in complex with an in situ formed triazole 分子名称: (4-CARBOXYPHENYL)(CHLORO)MERCURY, Carbonic anhydrase 2, N-[(S)-(1-{2-oxo-2-[(3-sulfanylpropyl)amino]ethyl}-1H-1,2,3-triazol-5-yl)(phenyl)methyl]-4-sulfamoylbenzamide, ... 著者 Schulze-Wischeler, J, Heine, A, Klebe, G. 登録日 2009-11-12 公開日 2011-05-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Stereo- and Regioselective Azide/Alkyne Cycloadditions in Carbonic Anhydrase II via Tethering, Monitored by Crystallography and Mass Spectrometry. Chemistry, 17, 2011
3KLD	PTPRG CNTN4 complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Contactin 4, Receptor-type tyrosine-protein phosphatase gamma 著者 Bouyain, S. 登録日 2009-11-07 公開日 2009-12-22 最終更新日 2021-03-31 実験手法 X-RAY DIFFRACTION (1.999 Å) 主引用文献 The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules. Proc.Natl.Acad.Sci.USA, 107, 2010
3KKX	Neutron structure of human carbonic anhydrase II 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Fisher, S.Z, Langan, P.A. 登録日 2009-11-06 公開日 2010-01-12 最終更新日 2023-09-06 実験手法 NEUTRON DIFFRACTION (2 Å) 主引用文献 Neutron structure of human carbonic anhydrase II: implications for proton transfer. Biochemistry, 49, 2010
3KIG	Mutant carbonic anhydrase II in complex with an azide and an alkyne 分子名称: 2-azido-N-(2-sulfanylethyl)ethanamide, 3-ethynylbenzenesulfonamide, Carbonic anhydrase 2, ... 著者 Schulze-Wischeler, J, Niehage, N.U, Heine, A, Klebe, G. 登録日 2009-11-02 公開日 2010-11-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Stereo- and Regioselective Azide/Alkyne Cycloadditions in Carbonic Anhydrase II via Tethering, Monitored by Crystallography and Mass Spectrometry. Chemistry, 17, 2011
3K7K	Crystal structure of the complex between Carbonic Anhydrase II and anions 分子名称: Carbonic anhydrase 2, MERCURY (II) ION, ZINC ION, ... 著者 Temperini, C. 登録日 2009-10-13 公開日 2010-01-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II-trithiocarbonate adduct-An inhibitor mimicking the sulfonamide and urea binding to the enzyme Bioorg.Med.Chem.Lett., 20, 2010
3K34	Human carbonic anhydrase II with a sulfonamide inhibitor 分子名称: (4-SULFAMOYL-PHENYL)-THIOCARBAMIC ACID O-(2-THIOPHEN-3-YL-ETHYL) ESTER, 4-(HYDROXYMERCURY)BENZOIC ACID, Carbonic anhydrase 2, ... 著者 Behnke, C.A, Le Trong, I, Merritt, E.A, Teller, D.C, Stenkamp, R.E. 登録日 2009-10-01 公開日 2010-05-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (0.9 Å) 主引用文献 Atomic resolution studies of carbonic anhydrase II. Acta Crystallogr.,Sect.D, 66, 2010
3K2F	Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma 分子名称: (2S)-2,3-bis(nitrooxy)propyl ethyl[(4S,6S)-6-methyl-7,7-dioxido-2-sulfamoyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-yl]carbamate, Carbonic anhydrase 2, MERCURY (II) ION, ... 著者 Temperini, C, Cecchi, A. 登録日 2009-09-30 公開日 2009-11-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma Bioorg.Med.Chem.Lett., 19, 2009
3JXH	CA-like domain of human PTPRG 分子名称: Receptor-type tyrosine-protein phosphatase gamma, SULFATE ION 著者 Bouyain, S. 登録日 2009-09-19 公開日 2009-12-22 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (1.701 Å) 主引用文献 The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules. Proc.Natl.Acad.Sci.USA, 107, 2010
3JXG	CA-like domain of mouse PTPRG 分子名称: Receptor-type tyrosine-protein phosphatase gamma 著者 Bouyain, S. 登録日 2009-09-19 公開日 2009-12-22 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules. Proc.Natl.Acad.Sci.USA, 107, 2010
3JXF	CA-like domain of human PTPRZ 分子名称: Receptor-type tyrosine-protein phosphatase zeta 著者 Bouyain, S. 登録日 2009-09-19 公開日 2009-12-22 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (2.004 Å) 主引用文献 The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules. Proc.Natl.Acad.Sci.USA, 107, 2010
3IGP	Structure of inhibitor binding to Carbonic Anhydrase II 分子名称: 6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Gitto, R, Agnello, S, Brynda, J, Mader, P, Supuran, C.T, Chimirri, A. 登録日 2009-07-28 公開日 2010-03-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as Potent Carbonic Anhydrase Inhibitors: Synthesis, Biological Evaluation, and Enzyme-Ligand X-ray Studies. J.Med.Chem., 2010
3IEO	The coumarin-binding site in carbonic anhydrase: the antiepileptic lacosamide as an example 分子名称: BENZOIC ACID, Carbonic anhydrase 2, MERCURY (II) ION, ... 著者 Temperini, C, Innocenti, A, Scozzafava, A, Parkkila, S, Supuran, C.T. 登録日 2009-07-23 公開日 2010-01-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors J.Med.Chem., 53, 2010
3IBU	The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor 分子名称: 4-(HYDROXYMERCURY)BENZOIC ACID, CHLORIDE ION, Carbonic anhydrase 2, ... 著者 Alterio, V, De Simone, G. 登録日 2009-07-17 公開日 2009-09-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors J.Med.Chem., 52, 2009
3IBN	The crystal structure of the human carbonic anhydrase II in complex with an aliphatic bis-sulfamate inhibitor 分子名称: 4-(HYDROXYMERCURY)BENZOIC ACID, CHLORIDE ION, Carbonic anhydrase 2, ... 著者 Alterio, V, De Simone, G. 登録日 2009-07-16 公開日 2009-09-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors J.Med.Chem., 52, 2009
3IBL	The crystal structure of the human carbonic anhydrase II in complex with an aliphatic bis-sulfamate inhibitor 分子名称: 4-(HYDROXYMERCURY)BENZOIC ACID, CHLORIDE ION, Carbonic anhydrase 2, ... 著者 Alterio, V, De Simone, G. 登録日 2009-07-16 公開日 2009-09-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors J.Med.Chem., 52, 2009
3IBI	The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor 分子名称: 4-(HYDROXYMERCURY)BENZOIC ACID, CHLORIDE ION, Carbonic anhydrase 2, ... 著者 Alterio, V, De Simone, G. 登録日 2009-07-16 公開日 2009-09-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors J.Med.Chem., 52, 2009
3IAI	Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase 9, ... 著者 Alterio, V, Di Fiore, A, De Simone, G. 登録日 2009-07-14 公開日 2009-09-08 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX. Proc.Natl.Acad.Sci.USA, 106, 2009

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