3K2F
Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma
Summary for 3K2F
Entry DOI | 10.2210/pdb3k2f/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (5 entities in total) |
Functional Keywords | carbonic anhydrase, no-donating agent, antiglaucoma drug, sulfonamide, xray crystallography, lyase, acetylation, cytoplasm, disease mutation, metal-binding, polymorphism, zinc |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 30087.58 |
Authors | Temperini, C.,Cecchi, A. (deposition date: 2009-09-30, release date: 2009-11-17, Last modification date: 2023-11-01) |
Primary citation | Steele, R.M.,Benedini, F.,Biondi, S.,Borghi, V.,Carzaniga, L.,Impagnatiello, F.,Miglietta, D.,Chong, W.K.,Rajapakse, R.,Cecchi, A.,Temperini, C.,Supuran, C.T. Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma Bioorg.Med.Chem.Lett., 19:6565-6570, 2009 Cited by PubMed: 19854054DOI: 10.1016/j.bmcl.2009.10.036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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