3LXE
Human Carbonic Anhydrase I in complex with topiramate
Summary for 3LXE
| Entry DOI | 10.2210/pdb3lxe/pdb |
| Descriptor | Carbonic anhydrase 1, ZINC ION, [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate, ... (4 entities in total) |
| Functional Keywords | carbonic anhydrase 1, topiramate, enzyme-inhibitor complex, lyase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P00915 |
| Total number of polymer chains | 2 |
| Total formula weight | 58359.52 |
| Authors | Alterio, V.,De Simone, G.,Monti, S.M.,Truppo, E. (deposition date: 2010-02-25, release date: 2010-07-21, Last modification date: 2023-11-01) |
| Primary citation | Alterio, V.,Monti, S.M.,Truppo, E.,Pedone, C.,Supuran, C.T.,De Simone, G. The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: the carbonic anhydrase I-topiramate complex. Org.Biomol.Chem., 2010 Cited by PubMed: 20505865DOI: 10.1039/b926832d PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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