6WMU
 
 | | E. coli RNAPs70-SspA-gadA DNA complex | | 分子名称: | DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ... | | 著者 | Travis, B.A, Brennan, R.G, Schumacher, M.A. | | 登録日 | 2020-04-21 | | 公開日 | 2020-11-11 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | | 主引用文献 | Structural Basis for Virulence Activation of Francisella tularensis.
Mol.Cell, 81, 2021
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6KQH
 | | Thermus thermophilus initial transcription complex comprising sigma A and 5'-OH RNA of 7 nt | | 分子名称: | DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Zhang, Y, Li, L, Ebright, R.H. | | 登録日 | 2019-08-17 | | 公開日 | 2020-03-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | | 主引用文献 | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
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5VI5
 | | Structure of Mycobacterium smegmatis transcription initiation complex with a full transcription bubble | | 分子名称: | 1,2-ETHANEDIOL, DNA (44-MER), DNA (49-MER), ... | | 著者 | Darst, S.A, Campbell, E.A, Lilic, M. | | 登録日 | 2017-04-14 | | 公開日 | 2017-07-26 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.196 Å) | | 主引用文献 | Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures.
Nat Commun, 8, 2017
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6KQM
 | | Thermus thermophilus initial transcription complex comprising sigma A and 5'-triphosphate RNA of 5 nt | | 分子名称: | DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Zhang, Y, Li, L, Ebright, R.H. | | 登録日 | 2019-08-18 | | 公開日 | 2020-03-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.197 Å) | | 主引用文献 | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6XLM
 | | Cryo-EM structure of E.coli RNAP-DNA elongation complex 1 (RDe1) in EcmrR-dependent transcription | | 分子名称: | 9-nt RNA transcript, CHAPSO, DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Yang, Y, Liu, C, Liu, B. | | 登録日 | 2020-06-28 | | 公開日 | 2021-04-07 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural visualization of transcription activated by a multidrug-sensing MerR family regulator.
Nat Commun, 12, 2021
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7P5X
 | | Mycobacterial RNAP with transcriptional activator PafBC | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Mueller, A.U, Kummer, E, Schilling, C.M, Ban, N, Weber-Ban, E. | | 登録日 | 2021-07-15 | | 公開日 | 2021-12-22 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Transcriptional control of mycobacterial DNA damage response by sigma adaptation.
Sci Adv, 7, 2021
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7MKD
 | | Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 1) | | 分子名称: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Saecker, R.M, Darst, S.A, Chen, J. | | 登録日 | 2021-04-23 | | 公開日 | 2021-09-29 | | 最終更新日 | 2021-10-13 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural origins of Escherichia coli RNA polymerase open promoter complex stability.
Proc.Natl.Acad.Sci.USA, 118, 2021
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5E17
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6VVV
 | | Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase | | 分子名称: | DNA (26-MER), DNA (31-MER), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Lilic, M, Darst, S.A, Campbell, E.A. | | 登録日 | 2020-02-18 | | 公開日 | 2020-10-21 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase.
Proc.Natl.Acad.Sci.USA, 117, 2020
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8U3B
 | | Cryo-EM structure of E. coli NarL-transcription activation complex at 3.2A | | 分子名称: | DNA (69-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Liu, B, Kompaniiets, D, Wang, D. | | 登録日 | 2023-09-07 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Structural basis for transcription activation by the nitrate-responsive regulator NarL.
Nucleic Acids Res., 52, 2024
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6N61
 | | Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA and Capistruin | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Capistruin, ... | | 著者 | Braffman, N, Hauver, J, Campbell, E.A, Darst, S.A. | | 登録日 | 2018-11-24 | | 公開日 | 2019-01-09 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.253 Å) | | 主引用文献 | Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6OMF
 | | CryoEM structure of SigmaS-transcription initiation complex with activator Crl | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Jaramillo Cartagena, A, Darst, S.A, Campbell, E.A. | | 登録日 | 2019-04-18 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | Structural basis for transcription activation by Crl through tethering of sigmaSand RNA polymerase.
Proc.Natl.Acad.Sci.USA, 116, 2019
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7L7B
 | | Clostridioides difficile RNAP with fidaxomicin | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Boyaci, H, Campbell, E.A, Darst, S.A, Chen, J. | | 登録日 | 2020-12-28 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile.
Nature, 604, 2022
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6C04
 | | Mtb RNAP Holo/RbpA/double fork DNA -closed clamp | | 分子名称: | DNA (26-MER), DNA (31-MER), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J, Lilic, M. | | 登録日 | 2017-12-27 | | 公開日 | 2018-03-28 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
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5D4C
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2CW0
 | | Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution | | 分子名称: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | | 著者 | Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark Jr, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E. | | 登録日 | 2005-06-15 | | 公開日 | 2005-09-20 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation
Cell(Cambridge,Mass.), 122, 2005
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5E18
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5VO8
 | | X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter | | 分子名称: | DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*CP*TP*GP*AP*TP*GP*CP*AP*CP*C)-3'), DNA (5'-D(P*GP*GP*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Murakami, K.S, Shin, Y, Turnbough Jr, C.L, Molodtsov, V. | | 登録日 | 2017-05-02 | | 公開日 | 2017-05-24 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7XYA
 | | The cryo-EM structure of an AlpA-loading complex | | 分子名称: | AlpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Wen, A, Feng, Y. | | 登録日 | 2022-06-01 | | 公開日 | 2022-07-20 | | 最終更新日 | 2022-08-24 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis of AlpA-dependent transcription antitermination.
Nucleic Acids Res., 50, 2022
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4KI2
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6KQD
 | | Thermus thermophilus initial transcription complex comprising sigma A and 5'-OH RNA of 3 nt | | 分子名称: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), ... | | 著者 | Zhang, Y, Li, L, Ebright, R.H. | | 登録日 | 2019-08-17 | | 公開日 | 2020-03-11 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6KQE
 | | Thermus thermophilus initial transcription complex comprising sigma A and 5'-OH RNA of 4 nt | | 分子名称: | DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Zhang, Y, Li, L, Ebright, R.H. | | 登録日 | 2019-08-17 | | 公開日 | 2020-03-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
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5X21
 | | Crystal structure of Thermus thermophilus transcription initiation complex with GpA and pseudouridimycin (PUM) | | 分子名称: | (1S)-1,4-anhydro-5-[(N-carbamimidoylglycyl-N~2~-hydroxy-L-glutaminyl)amino]-5-deoxy-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Zhang, Y, Ebright, R. | | 登録日 | 2017-01-29 | | 公開日 | 2017-07-05 | | 最終更新日 | 2022-10-12 | | 実験手法 | X-RAY DIFFRACTION (3.323 Å) | | 主引用文献 | Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase.
Cell, 169, 2017
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7EH2
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5X22
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