PDB: 663 件ウェブページステータス検索Chemie searchBIRD

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2I3W	Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of S729C mutant 分子名称: GLUTAMATE RECEPTOR SUBUNIT 2, GLUTAMIC ACID 著者 Armstrong, N, Jasti, J, Beich-Frandsen, M, Gouaux, E. 登録日 2006-08-21 公開日 2006-10-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor. Cell(Cambridge,Mass.), 127, 2006
2I3V	Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant 分子名称: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION 著者 Armstrong, N, Jasti, J, Beich-Frandsen, M, Gouaux, E. 登録日 2006-08-21 公開日 2006-10-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor. Cell(Cambridge,Mass.), 127, 2006
2OJT	Structure and mechanism of kainate receptor modulation by anions 分子名称: (S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHENE-3-YL-METHYL)-5-METHYLPYRIMIDINE-2,4-DIONE, BROMIDE ION, Glutamate receptor, ... 著者 Mayer, M.L. 登録日 2007-01-14 公開日 2007-04-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure and mechanism of kainate receptor modulation by anions. Neuron, 53, 2007
2P2A	X-ray structure of the GluR2 ligand binding core (S1S2J) in complex with 2-Bn-tet-AMPA at 2.26A resolution 分子名称: 2-AMINO-3-[3-HYDROXY-5-(2-BENZYL-2H-5-TETRAZOLYL)-4-ISOXAZOLYL]-PROPIONIC ACID, GLUTAMIC ACID, Glutamate receptor 2, ... 著者 Frydenvang, K, Kastrup, J.S, Gajhede, M. 登録日 2007-03-07 公開日 2007-06-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 A tetrazolyl-substituted subtype-selective AMPA receptor agonist. J.Med.Chem., 50, 2007
2UXA	Crystal structure of the GluR2-flip ligand binding domain, r/g unedited. 分子名称: GLUTAMATE RECEPTOR SUBUNIT GLUR2-FLIP, GLUTAMIC ACID, ZINC ION 著者 Greger, I.H, Akamine, P, Khatri, L, Ziff, E.B. 登録日 2007-03-27 公開日 2007-04-10 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Developmentally Regulated, Combinatorial RNA Processing Modulates Ampa Receptor Biogenesis. Neuron, 51, 2006
2PBW	Crystal Structure of the Ligand-Binding Core of iGluR5 in Complex with the Partial agonist Domoic Acid at 2.5 A Resolution 分子名称: (2S,3S,4S)-2-CARBOXY-4-[(1Z,3E,5R)-5-CARBOXY-1-METHYL-1,3-HEXADIENYL]-3-PYRROLIDINEACETIC ACID, Glutamate receptor, ionotropic kainate 1 著者 Hald, H, Naur, P, Gajhede, M, Kastrup, J.S. 登録日 2007-03-29 公開日 2007-07-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid. J.Biol.Chem., 282, 2007
1VSO	Crystal Structure of the Ligand-Binding Core of iGluR5 in Complex With the Antagonist (S)-ATPO at 1.85 A resolution 分子名称: (S)-2-AMINO-3-(5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL)PROPIONIC ACID, GLYCEROL, Glutamate receptor, ... 著者 Hald, H, Naur, P, Gajhede, M, Kastrup, J.S. 登録日 2007-03-29 公開日 2007-07-03 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid. J.Biol.Chem., 282, 2007
2V3T	Structure of the ligand-binding core of the ionotropic glutamate receptor-like GluRdelta2 in the apo form 分子名称: CALCIUM ION, GLUTAMATE RECEPTOR DELTA-2 SUBUNIT SYNONYM GLURDELTA2, GLUR DELTA-2 著者 Naur, P, Vestergaard, B, Gajhede, M, Kastrup, J.S. 登録日 2007-06-22 公開日 2007-08-07 最終更新日 2019-07-24 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Ionotropic Glutamate-Like Receptor {Delta}2 Binds D-Serine and Glycine. Proc.Natl.Acad.Sci.USA, 104, 2007
2V3U	Structure of the ligand-binding core of the ionotropic glutamate receptor-like GluRdelta2 in complex with D-serine 分子名称: CHLORIDE ION, D-SERINE, GLUTAMATE RECEPTOR DELTA-2 SUBUNIT, ... 著者 Naur, P, Vestergaard, B, Gajhede, M, Kastrup, J.S. 登録日 2007-06-22 公開日 2007-08-07 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Ionotropic Glutamate-Like Receptor {Delta}2 Binds D-Serine and Glycine. Proc.Natl.Acad.Sci.USA, 104, 2007
2QS4	Crystal structure of the GluR5 ligand binding core dimer in complex with LY466195 at 1.58 Angstroms resolution 分子名称: (3S,4aR,6S,8aR)-6-{[(2S)-2-carboxy-4,4-difluoropyrrolidin-1-yl]methyl}decahydroisoquinoline-3-carboxylic acid, AMMONIUM ION, GLYCEROL, ... 著者 Alushin, G.M, Jane, D.E, Mayer, M.L. 登録日 2007-07-30 公開日 2008-08-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists. Neuropharmacology, 60, 2011
2QS1	Crystal structure of the GluR5 ligand binding core dimer in complex with UBP315 at 1.80 Angstroms resolution 分子名称: 3-({3-[(2S)-2-amino-2-carboxyethyl]-5-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)-4,5-dibromothiophene-2-carboxylic acid, CHLORIDE ION, Glutamate receptor, ... 著者 Alushin, G.M, Jane, D.E, Mayer, M.L. 登録日 2007-07-30 公開日 2008-08-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists. Neuropharmacology, 60, 2011
2QS2	Crystal structure of the GluR5 ligand binding core dimer in complex with UBP318 at 1.80 Angstroms resolution 分子名称: 3-({3-[(2S)-2-amino-2-carboxyethyl]-5-bromo-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)thiophene-2-carboxylic acid, CHLORIDE ION, Glutamate receptor, ... 著者 Alushin, G.M, Jane, D.E, Mayer, M.L. 登録日 2007-07-30 公開日 2008-08-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists. Neuropharmacology, 60, 2011
2QS3	Crystal structure of the GluR5 ligand binding core dimer in complex with UBP316 at 1.76 Angstroms resolution 分子名称: 3-({3-[(2S)-2-amino-2-carboxyethyl]-5-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)-5-phenylthiophene-2-carboxylic acid, CHLORIDE ION, Glutamate receptor, ... 著者 Alushin, G.M, Jane, D.E, Mayer, M.L. 登録日 2007-07-30 公開日 2008-08-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function. Neuropharmacology, 56, 2009
2RCA	Crystal structure of the NR3B ligand binding core complex with glycine at 1.58 Angstrom resolution 分子名称: GLYCEROL, GLYCINE, Glutamate [NMDA] receptor subunit 3B 著者 Yao, Y, Mayer, M.L. 登録日 2007-09-19 公開日 2008-08-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors. Embo J., 27, 2008
2RC8	Crystal structure of the NR3A ligand binding core complex with D-serine at 1.45 Angstrom resolution 分子名称: CHLORIDE ION, D-SERINE, GLYCEROL, ... 著者 Yao, Y, Mayer, M.L. 登録日 2007-09-19 公開日 2008-08-05 最終更新日 2017-08-23 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors. Embo J., 27, 2008
2RC9	Crystal structure of the NR3A ligand binding core complex with ACPC at 1.96 Angstrom resolution 分子名称: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, Glutamate [NMDA] receptor subunit 3A 著者 Yao, Y, Mayer, M.L. 登録日 2007-09-19 公開日 2008-08-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors. Embo J., 27, 2008
2RCB	Crystal structure of the NR3B ligand binding core complex with D-serine at 1.62 Angstrom resolution 分子名称: D-SERINE, GLYCEROL, Glutamate [NMDA] receptor subunit 3B 著者 Yao, Y, Mayer, M.L. 登録日 2007-09-19 公開日 2008-08-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors. Embo J., 27, 2008
2RC7	Crystal structure of the NR3A ligand binding core complex with glycine at 1.58 Angstrom resolution 分子名称: BROMIDE ION, CHLORIDE ION, GLYCEROL, ... 著者 Yao, Y, Mayer, M.L. 登録日 2007-09-19 公開日 2008-08-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors. Embo J., 27, 2008
3B6T	Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) T686A Mutant in Complex with Quisqualate at 2.1 Resolution 分子名称: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 2, SULFATE ION 著者 Cho, Y, Lolis, E, Howe, J.R. 登録日 2007-10-29 公開日 2008-02-05 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating. J.Neurosci., 28, 2008
3B6Q	Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) Mutant T686A in Complex with Glutamate at 2.0 Resolution 分子名称: GLUTAMIC ACID, Glutamate receptor 2, SULFATE ION 著者 Cho, Y, Lolis, E, Howe, J.R. 登録日 2007-10-29 公開日 2008-02-05 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating. J.Neurosci., 28, 2008
3B6W	Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) T686S Mutant in Complex with Glutamate at 1.7 Resolution 分子名称: GLUTAMIC ACID, Glutamate receptor 2, SULFATE ION 著者 Cho, Y, Lolis, E, Howe, J.R. 登録日 2007-10-29 公開日 2008-02-05 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating. J.Neurosci., 28, 2008
3B7D	Crystal structure of the GLUR2 ligand binding core (HS1S2J) in complex with CNQX at 2.5 A resolution 分子名称: 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile, Glutamate receptor 2 著者 Hays, F.A, Center for Structures of Membrane Proteins (CSMP) 登録日 2007-10-30 公開日 2007-11-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists. Science, 318, 2007
3BBR	Crystal structure of the iGluR2 ligand binding core (S1S2J-N775S) in complex with a dimeric positive modulator as well as glutamate at 2.25 A resolution 分子名称: CHLORIDE ION, GLUTAMIC ACID, GLYCEROL, ... 著者 Kastrup, J.S, Gajhede, M. 登録日 2007-11-11 公開日 2007-12-04 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites Chem.Biol., 14, 2007
3BFT	Structure of the ligand-binding core of GluR2 in complex with the agonist (S)-TDPA at 2.25 A resolution 分子名称: (2S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid, CACODYLATE ION, CHLORIDE ION, ... 著者 Beich-Frandsen, M, Mirza, O, Vestergaard, B, Gajhede, M, Kastrup, J.S. 登録日 2007-11-23 公開日 2008-10-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency. J.Med.Chem., 51, 2008
3BFU	Structure of the ligand-binding core of GluR2 in complex with the agonist (R)-TDPA at 1.95 A resolution 分子名称: (2R)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid, Glutamate receptor 2 著者 Beich-Frandsen, M, Mirza, O, Vestergaard, B, Gajhede, M, Kastrup, J.S. 登録日 2007-11-23 公開日 2008-10-14 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency. J.Med.Chem., 51, 2008

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