4KU7
| Structures of PKGI Reveal a cGMP-Selective Activation Mechanism | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, IODIDE ION, cGMP-dependent protein kinase 1 | 著者 | Huang, G.Y, Kim, J.J, Reger, A.S, Lorenz, R, Moon, E.W, Casteel, D.E, Sankaran, B, Herberg, F.W, Kim, C. | 登録日 | 2013-05-21 | 公開日 | 2014-01-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I. Structure, 22, 2014
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4L11
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5J3U
| Co-crystal structure of the regulatory domain of Toxoplasma gondii PKA with cAMP | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, GLYCEROL, Protein Kinase A | 著者 | El Bakkouri, M, Walker, J.R, Tempel, W, Loppnau, P, Graslund, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Lin, L, Structural Genomics Consortium (SGC) | 登録日 | 2016-03-31 | 公開日 | 2016-04-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Co-crystal structure of the regulatory domain of Toxoplasma gondii PKA with cAMP To Be Published
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5J48
| PKG I's Carboyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-pCPT-cGMP | 分子名称: | 1,2-ETHANEDIOL, 2-amino-8-[(4-chlorophenyl)sulfanyl]-9-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-3,9-dihydro-6H-purin-6-one, CALCIUM ION, ... | 著者 | Campbell, J.C, Sankaran, B, Kim, C.W. | 登録日 | 2016-03-31 | 公開日 | 2017-04-12 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Structural Basis of Analog Specificity in PKG I and II. ACS Chem. Biol., 12, 2017
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5JD7
| PKG I's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with PET-cGMP | 分子名称: | 3-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-6-phenyl-3,4-dihydro-9H-imidazo[1,2-a]purin-9-one, cGMP-dependent protein kinase 1 | 著者 | Campbell, J.C, Sankaran, B, Kim, C.W. | 登録日 | 2016-04-15 | 公開日 | 2017-08-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.749 Å) | 主引用文献 | Structural Basis of Analog Specificity in PKG I and II. ACS Chem. Biol., 12, 2017
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5JAX
| PKG I's Carboyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-Br-cGMP | 分子名称: | 2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one, CALCIUM ION, SODIUM ION, ... | 著者 | Campbell, J.C, Sankaran, B, Kim, C.W. | 登録日 | 2016-04-12 | 公開日 | 2017-04-19 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.486 Å) | 主引用文献 | Structural Basis of Analog Specificity in PKG I and II. ACS Chem. Biol., 12, 2017
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5JIX
| PKG II's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-Br-cGMP | 分子名称: | 1,2-ETHANEDIOL, 2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ... | 著者 | Campbell, J.C, Kim, C.W. | 登録日 | 2016-04-22 | 公開日 | 2017-05-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Structural Basis of Analog Specificity in PKG I and II. ACS Chem. Biol., 12, 2017
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5JIZ
| PKG II's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-pCPT-cGMP | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-amino-8-[(4-chlorophenyl)sulfanyl]-9-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-3,9-dihydro-6H-purin-6-one, CALCIUM ION, ... | 著者 | Campbell, J.C, Kim, C.W. | 登録日 | 2016-04-22 | 公開日 | 2017-05-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | PKG II's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-pCPT-cGMP To Be Published
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5KBF
| cAMP bound PfPKA-R (141-441) | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CAMP-dependent protein kinase regulatory subunit, putative | 著者 | Littler, D.R, Gilson, P.R, Crabb, B.S, Rossjohn, J.J. | 登録日 | 2016-06-03 | 公開日 | 2016-10-12 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit. J. Biol. Chem., 291, 2016
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5KHI
| HCN2 CNBD in complex with purine riboside-3', 5'-cyclic monophosphate (cPuMP) | 分子名称: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, Purine riboside-3',5'-cyclic monophosphate | 著者 | Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A. | 登録日 | 2016-06-14 | 公開日 | 2016-09-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening. Structure, 24, 2016
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5KHJ
| HCN2 CNBD in complex with uridine-3', 5'-cyclic monophosphate (cUMP) | 分子名称: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, Uridine-3',5'-cyclic monophosphate | 著者 | Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A. | 登録日 | 2016-06-14 | 公開日 | 2016-09-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening. Structure, 24, 2016
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5K8S
| cAMP bound PfPKA-R (297-441) | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CAMP-dependent protein kinase regulatory subunit | 著者 | Littler, D.R, Gilson, P.R, Crabb, B.S, Rossjohn, J.J. | 登録日 | 2016-05-31 | 公開日 | 2016-10-12 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit. J. Biol. Chem., 291, 2016
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5KHK
| HCN2 CNBD in complex with 2-aminopurine riboside-3', 5'-cyclic monophosphate (2-NH2-cPuMP) | 分子名称: | 2-Aminopurine riboside-3',5'-cyclic monophosphate, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | 著者 | Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A. | 登録日 | 2016-06-14 | 公開日 | 2016-09-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening. Structure, 24, 2016
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5KHG
| HCN2 CNBD in complex with cytidine-3', 5'-cyclic monophosphate (cCMP) | 分子名称: | 4-amino-1-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrimidin-2(1H)-one, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | 著者 | Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A. | 登録日 | 2016-06-14 | 公開日 | 2016-09-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.241 Å) | 主引用文献 | Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening. Structure, 24, 2016
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5KHH
| HCN2 CNBD in complex with inosine-3', 5'-cyclic monophosphate (cIMP) | 分子名称: | Inosine-3',5'-cyclic monophosphate, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | 著者 | Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A. | 登録日 | 2016-06-14 | 公開日 | 2016-09-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening. Structure, 24, 2016
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5KJX
| Co-crystal Structure of PKA RI alpha CNB-B domain with cAMP | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cAMP-dependent protein kinase type I-alpha regulatory subunit | 著者 | Lorenz, R, Moon, E, Kim, J.J, Huang, G.Y, Kim, C, Herberg, F.W. | 登録日 | 2016-06-20 | 公開日 | 2017-06-28 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity. Biochem. J., 474, 2017
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5KJY
| Co-crystal structure of PKA RI alpha CNB-B mutant (G316R/A336T) with cAMP | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cAMP-dependent protein kinase type I-alpha regulatory subunit | 著者 | Lorenz, R, Moon, E, Kim, J.J, Huang, G.Y, Kim, C, Herberg, F.W. | 登録日 | 2016-06-20 | 公開日 | 2017-06-28 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity. Biochem. J., 474, 2017
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5L0N
| PKG I's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with RP-cGMP | 分子名称: | 1,2-ETHANEDIOL, 2-amino-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydroxy-2-sulfanylidenetetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-3,9-dihydro-6H-purin-6-one, CALCIUM ION, ... | 著者 | Campbell, J.C, Sankaran, B, Kim, C.W. | 登録日 | 2016-07-27 | 公開日 | 2017-08-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.285 Å) | 主引用文献 | Structure of PKG I CNB-B bound to RP-cGMP To Be Published
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5KJZ
| Co-crystal structure of PKA RI alpha CNB-B mutant (G316R/A336T) with cGMP | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, GLYCEROL, cAMP-dependent protein kinase type I-alpha regulatory subunit | 著者 | Lorenz, R, Moon, E, Kim, J.J, Huang, G.Y, Kim, C, Herberg, F.W. | 登録日 | 2016-06-20 | 公開日 | 2017-06-28 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.347 Å) | 主引用文献 | Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity. Biochem. J., 474, 2017
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3BPZ
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3CLP
| M. loti cyclic-nucleotide binding domain mutant 2 | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Mll3241 protein | 著者 | Clayton, G.M, Altieri, S.L, Thomas, L.R, Morais-Cabral, J.H. | 登録日 | 2008-03-19 | 公開日 | 2008-08-05 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and Energetic Analysis of Activation by a Cyclic Nucleotide Binding Domain. J.Mol.Biol., 381, 2008
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3CO2
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3CL1
| M. loti cyclic-nucleotide binding domain, cyclic-GMP bound | 分子名称: | CHLORIDE ION, CYCLIC GUANOSINE MONOPHOSPHATE, Mll3241 protein, ... | 著者 | Clayton, G.M, Alteiri, S.L, Thomas, L.R, Morais-Cabral, J.H. | 登録日 | 2008-03-18 | 公開日 | 2008-08-05 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and Energetic Analysis of Activation by a Cyclic Nucleotide Binding Domain. J.Mol.Biol., 381, 2008
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3ETQ
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3FFQ
| HCN2I 443-640 apo-state | 分子名称: | BROMIDE ION, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | 著者 | Olivier, N.B. | 登録日 | 2008-12-04 | 公開日 | 2009-06-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Mapping the structure and conformational movements of proteins with transition metal ion FRET. Nat.Methods, 6, 2009
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