3PSJ
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1WQU
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![BU of 1wqu by Molmil](/molmil-images/mine/1wqu) | Solution structure of the human FES SH2 domain | 分子名称: | Proto-oncogene tyrosine-protein kinase FES/FPS | 著者 | Scott, A, Pantoja-Uceda, D, Koshiba, S, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Tanaka, A, Sugano, S, Yokoyama, S, Guntert, P, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2004-10-02 | 公開日 | 2005-06-14 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes J.Biomol.NMR, 31, 2005
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1X0N
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![BU of 1x0n by Molmil](/molmil-images/mine/1x0n) | NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor | 分子名称: | 4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAPHTHYLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL]BENZYLPHOSPHONIC ACID, Growth factor receptor-bound protein 2 | 著者 | Ogura, K, Shiga, T, Yuzawa, S, Yokochi, M, Burke, T.R, Inagaki, F. | 登録日 | 2005-03-24 | 公開日 | 2005-04-19 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor To be Published
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3PSK
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1X6C
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![BU of 1x6c by Molmil](/molmil-images/mine/1x6c) | Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1 | 分子名称: | Tyrosine-protein phosphatase, non-receptor type 6 | 著者 | Sato, M, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2005-05-17 | 公開日 | 2005-11-17 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1 To be Published
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3OV1
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5CDW
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![BU of 5cdw by Molmil](/molmil-images/mine/5cdw) | Crystal Structure Analysis of a mutant Grb2 SH2 domain (W121G) with a pYVNV peptide | 分子名称: | Growth factor receptor-bound protein 2, SER-PTR-VAL-ASN-VAL-GLN | 著者 | Papaioannou, D, Geibel, S, Kunze, M, Kay, C, Waksman, G. | 登録日 | 2015-07-05 | 公開日 | 2016-05-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | 主引用文献 | Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide. Protein Sci., 25, 2016
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5D0J
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![BU of 5d0j by Molmil](/molmil-images/mine/5d0j) | Grb7 SH2 with inhibitor peptide | 分子名称: | G7-TEdFP peptide, Growth factor receptor-bound protein 7, PHOSPHATE ION | 著者 | Gunzburg, M.J, Watson, G.M, Wilce, J.A, Wilce, M.C.J. | 登録日 | 2015-08-03 | 公開日 | 2016-06-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
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5DF6
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![BU of 5df6 by Molmil](/molmil-images/mine/5df6) | Crystal structure of PTPN11 tandem SH2 domains in complex with a TXNIP peptide | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11, UNKNOWN ATOM OR ION, txnip | 著者 | Dong, A, Li, W, Tempel, W, Liu, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2015-08-26 | 公開日 | 2015-09-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP. Biochem.J., 473, 2016
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5AUL
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![BU of 5aul by Molmil](/molmil-images/mine/5aul) | PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex | 分子名称: | GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, T-cell-specific surface glycoprotein CD28 | 著者 | Inaba, S, Numoto, N, Morii, H, Ikura, T, Oda, M, Ito, N. | 登録日 | 2015-04-28 | 公開日 | 2016-05-25 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins J. Biol. Chem., 292, 2017
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6KC4
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4K45
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4K44
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8ATK
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4P9V
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4P9Z
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4EIH
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![BU of 4eih by Molmil](/molmil-images/mine/4eih) | Crystal structure of Arg SH2 domain | 分子名称: | Abelson tyrosine-protein kinase 2, CHLORIDE ION | 著者 | Liu, W, MacGrath, S.M, Koleske, A.J, Boggon, T.J. | 登録日 | 2012-04-05 | 公開日 | 2013-04-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin. J.Biol.Chem., 289, 2014
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4EY0
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![BU of 4ey0 by Molmil](/molmil-images/mine/4ey0) | Structure of tandem SH2 domains from PLCgamma1 | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 著者 | Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. | 登録日 | 2012-05-01 | 公開日 | 2012-10-31 | 最終更新日 | 2013-06-19 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation. Structure, 20, 2012
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4F5A
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![BU of 4f5a by Molmil](/molmil-images/mine/4f5a) | Triple mutant Src SH2 domain bound to phosphate ion | 分子名称: | PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase Src | 著者 | Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. | 登録日 | 2012-05-12 | 公開日 | 2012-10-03 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
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4F59
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![BU of 4f59 by Molmil](/molmil-images/mine/4f59) | Triple mutant Src SH2 domain | 分子名称: | Proto-oncogene tyrosine-protein kinase Src | 著者 | Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. | 登録日 | 2012-05-12 | 公開日 | 2012-10-03 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
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4F5B
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![BU of 4f5b by Molmil](/molmil-images/mine/4f5b) | Triple mutant Src SH2 domain bound to phosphotyrosine | 分子名称: | O-PHOSPHOTYROSINE, Proto-oncogene tyrosine-protein kinase Src | 著者 | Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. | 登録日 | 2012-05-12 | 公開日 | 2012-10-03 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
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4FBN
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![BU of 4fbn by Molmil](/molmil-images/mine/4fbn) | Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 著者 | Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. | 登録日 | 2012-05-23 | 公開日 | 2012-10-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation. Structure, 20, 2012
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1A1A
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1A08
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1A09
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