PDB: 595 件ウェブページステータス検索Chemie searchBIRD

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3PSJ	Crystal Structure of the Spt6 Tandem SH2 Domain from Saccharomyces cerevisiae, Form Se-Spt6 (1247-1451) 分子名称: SULFATE ION, Transcription elongation factor SPT6 著者 Close, D, Hill, C.P. 登録日 2010-12-01 公開日 2011-03-30 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2.702 Å) 主引用文献 Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
1WQU	Solution structure of the human FES SH2 domain 分子名称: Proto-oncogene tyrosine-protein kinase FES/FPS 著者 Scott, A, Pantoja-Uceda, D, Koshiba, S, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Tanaka, A, Sugano, S, Yokoyama, S, Guntert, P, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2004-10-02 公開日 2005-06-14 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes J.Biomol.NMR, 31, 2005
1X0N	NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor 分子名称: 4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAPHTHYLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL]BENZYLPHOSPHONIC ACID, Growth factor receptor-bound protein 2 著者 Ogura, K, Shiga, T, Yuzawa, S, Yokochi, M, Burke, T.R, Inagaki, F. 登録日 2005-03-24 公開日 2005-04-19 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor To be Published
3PSK	Crystal Structure of the Spt6 Tandem SH2 Domain from Saccharomyces cerevisiae, Form Native Spt6 (1247-1451) 分子名称: SULFATE ION, Transcription elongation factor SPT6 著者 Close, D, Hill, C.P. 登録日 2010-12-01 公開日 2011-03-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
1X6C	Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1 分子名称: Tyrosine-protein phosphatase, non-receptor type 6 著者 Sato, M, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-05-17 公開日 2005-11-17 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1 To be Published
3OV1	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide 分子名称: FORMIC ACID, GLYCEROL, Growth factor receptor-bound protein 2, ... 著者 Clements, J.H, Martin, S.F. 登録日 2010-09-15 公開日 2011-11-02 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
5CDW	Crystal Structure Analysis of a mutant Grb2 SH2 domain (W121G) with a pYVNV peptide 分子名称: Growth factor receptor-bound protein 2, SER-PTR-VAL-ASN-VAL-GLN 著者 Papaioannou, D, Geibel, S, Kunze, M, Kay, C, Waksman, G. 登録日 2015-07-05 公開日 2016-05-25 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.602 Å) 主引用文献 Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide. Protein Sci., 25, 2016
5D0J	Grb7 SH2 with inhibitor peptide 分子名称: G7-TEdFP peptide, Growth factor receptor-bound protein 7, PHOSPHATE ION 著者 Gunzburg, M.J, Watson, G.M, Wilce, J.A, Wilce, M.C.J. 登録日 2015-08-03 公開日 2016-06-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
5DF6	Crystal structure of PTPN11 tandem SH2 domains in complex with a TXNIP peptide 分子名称: Tyrosine-protein phosphatase non-receptor type 11, UNKNOWN ATOM OR ION, txnip 著者 Dong, A, Li, W, Tempel, W, Liu, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2015-08-26 公開日 2015-09-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP. Biochem.J., 473, 2016
5AUL	PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex 分子名称: GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, T-cell-specific surface glycoprotein CD28 著者 Inaba, S, Numoto, N, Morii, H, Ikura, T, Oda, M, Ito, N. 登録日 2015-04-28 公開日 2016-05-25 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins J. Biol. Chem., 292, 2017
6KC4	Crystal structure of human Fer SH2 domain bound to a phosphopeptide (DEpYENVD) 分子名称: Tyrosine-protein kinase Fer, phosphopeptide (EDpYENVD) 著者 Matsuura, Y. 登録日 2019-06-27 公開日 2019-09-04 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 High-resolution structural analysis shows how different crystallographic environments can induce alternative modes of binding of a phosphotyrosine peptide to the SH2 domain of Fer tyrosine kinase. Protein Sci., 28, 2019
4K45	Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, short peptide 著者 Sondek, J, Hajicek, N. 登録日 2013-04-11 公開日 2013-06-26 最終更新日 2014-01-22 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes. Biochemistry, 52, 2013
4K44	Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 著者 Hajicek, N, Sondek, J. 登録日 2013-04-11 公開日 2013-06-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes. Biochemistry, 52, 2013
8ATK	The SH2 domain of mouse SH2B1 分子名称: SH2B adapter protein 1 著者 Fowler, N.J, Williamson, M.P, Albalwi, M.F. 登録日 2022-08-23 公開日 2023-05-24 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Improved methodology for protein NMR structure calculation using hydrogen bond restraints and ANSURR validation: The SH2 domain of SH2B1. Structure, 31, 2023
4P9V	Grb2 SH2 complexed with a pTyr-Ac6cN-Asn tripeptide 分子名称: CHLORIDE ION, Growth factor receptor-bound protein 2, PHQ-PTR-02K-ASN-NH2 著者 Clements, J.H, Martin, S.F. 登録日 2014-04-06 公開日 2014-06-18 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction. Bioorg.Med.Chem.Lett., 24, 2014
4P9Z	Grb2 SH2 complexed with a pTyr-Ac6c-Asn tripeptide 分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ... 著者 Clements, J.H, Martin, S.F. 登録日 2014-04-06 公開日 2014-06-18 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction. Bioorg.Med.Chem.Lett., 24, 2014
4EIH	Crystal structure of Arg SH2 domain 分子名称: Abelson tyrosine-protein kinase 2, CHLORIDE ION 著者 Liu, W, MacGrath, S.M, Koleske, A.J, Boggon, T.J. 登録日 2012-04-05 公開日 2013-04-10 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin. J.Biol.Chem., 289, 2014
4EY0	Structure of tandem SH2 domains from PLCgamma1 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 著者 Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. 登録日 2012-05-01 公開日 2012-10-31 最終更新日 2013-06-19 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation. Structure, 20, 2012
4F5A	Triple mutant Src SH2 domain bound to phosphate ion 分子名称: PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase Src 著者 Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. 登録日 2012-05-12 公開日 2012-10-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
4F59	Triple mutant Src SH2 domain 分子名称: Proto-oncogene tyrosine-protein kinase Src 著者 Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. 登録日 2012-05-12 公開日 2012-10-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
4F5B	Triple mutant Src SH2 domain bound to phosphotyrosine 分子名称: O-PHOSPHOTYROSINE, Proto-oncogene tyrosine-protein kinase Src 著者 Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. 登録日 2012-05-12 公開日 2012-10-03 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
4FBN	Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 著者 Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. 登録日 2012-05-23 公開日 2012-10-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation. Structure, 20, 2012
1A1A	C-SRC (SH2 DOMAIN WITH C188A MUTATION) COMPLEXED WITH ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE) 分子名称: ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE), C-SRC TYROSINE KINASE 著者 Shewchuk, L, Jordan, S. 登録日 1997-12-10 公開日 1998-04-08 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study. Biochemistry, 36, 1997
1A08	C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-DIFLUORO PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE) 分子名称: ACE-DIFLUORO PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE), C-SRC TYROSINE KINASE 著者 Shewchuk, L, Jordan, S. 登録日 1997-12-09 公開日 1998-04-08 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study. Biochemistry, 36, 1997
1A09	C-src (SH2 domain) complexed with ace-formyl phosphotyr-glu-(n,n-dipentyl amine) 分子名称: ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE), C-SRC TYROSINE KINASE 著者 Shewchuk, L, Jordan, S. 登録日 1997-12-10 公開日 1998-04-08 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study. Biochemistry, 36, 1997

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