PDB: 95574 件ウェブページステータス検索Chemie searchBIRD

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3MDL	X-ray crystal structure of 1-arachidonoyl glycerol bound to the cyclooxygenase channel of cyclooxygenase-2 分子名称: (2S)-2,3-dihydroxypropyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Vecchio, A.J, Malkowski, M.G. 登録日 2010-03-30 公開日 2011-04-13 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. J.Biol.Chem., 286, 2011
4DUI	DARPIN D1 binding to tubulin beta chain (not in complex) 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN) D1 著者 Pecqueur, L, Duellberg, C, Dreier, B, Wang, Q, Jiang, C, Pluckthun, A, Surrey, T, Gigant, B, Knossow, M. 登録日 2012-02-22 公開日 2013-02-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.16 Å) 主引用文献 An Anti-Tubulin Darpin Caps the Microtubule Plus-End To be Published
4DQI	Ternary complex of Bacillus DNA Polymerase I Large Fragment, DNA duplex, and dCTP (paired with dG of template) 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*C*AP*TP*GP*GP*GP*AP*GP*TP*CP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*(DOC))-3'), ... 著者 Wang, W, Beese, L.S. 登録日 2012-02-15 公開日 2012-06-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides. J.Biol.Chem., 287, 2012
4DS5	Ternary complex of Bacillus DNA Polymerase I Large Fragment, DNA duplex, and rCTP in presence of Mg2+ 分子名称: DNA (5'-D(*CP*AP*TP*GP*GP*GP*AP*GP*TP*CP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*C)-3'), DNA polymerase, ... 著者 Wang, W, Beese, L.S. 登録日 2012-02-17 公開日 2012-06-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides. J.Biol.Chem., 287, 2012
4DZA	Crystal structure of a lysine racemase within internal aldimine linkage 分子名称: lysine racemase 著者 Wang, W.C, Wu, H.M. 登録日 2012-03-01 公開日 2013-03-06 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Crystal structures of lysine-preferred racemases, the non-antibiotic selectable markers for transgenic plants Plos One, 7, 2012
3ONZ	Human tetrameric hemoglobin: proximal nitrite ligand at beta 分子名称: Hemoglobin subunit alpha, Hemoglobin subunit beta, NITRITE ION, ... 著者 Yi, J, Thormas, L.M, Safo, M.K, Musayev, F.N, Richter-Addo, G.B. 登録日 2010-08-30 公開日 2011-09-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.087 Å) 主引用文献 Crystallographic Trapping of Heme Loss Intermediates during the Nitrite-Induced Degradation of Human Hemoglobin. Biochemistry, 50, 2011
4NST	Crystal structure of human Cdk12/Cyclin K in complex with ADP-aluminum fluoride 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, ... 著者 Boesken, C.A, Farnung, L, Anand, K, Geyer, M. 登録日 2013-11-29 公開日 2014-03-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The structure and substrate specificity of human Cdk12/Cyclin K. Nat Commun, 5, 2014
3OO5	R-state human hemoglobin: nitriheme modified 分子名称: Hemoglobin subunit alpha, Hemoglobin subunit beta, NITRITE ION, ... 著者 Yi, J, Thormas, L.M, Richter-Addo, G.B. 登録日 2010-08-30 公開日 2011-09-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystallographic Trapping of Heme Loss Intermediates during the Nitrite-Induced Degradation of Human Hemoglobin. Biochemistry, 50, 2011
4DKJ	CpG specific methyltransferase in complex with target DNA 分子名称: Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(C37)P*GP*CP*TP*GP*AP*A)-3'), DNA (5'-D(*GP*TP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*TP*G)-3'), ... 著者 Wojciechowski, M, Czapinska, H, Bochtler, M. 登録日 2012-02-03 公開日 2012-12-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 CpG underrepresentation and the bacterial CpG-specific DNA methyltransferase M.MpeI. Proc.Natl.Acad.Sci.USA, 110, 2013
7UJO	Estrogen Receptor Alpha Ligand Binding Domain in Complex with RU39411 分子名称: (9beta,11beta,17beta)-11-{4-[2-(dimethylamino)ethoxy]phenyl}estra-1,3,5(10)-triene-3,17-diol, Estrogen receptor, MAGNESIUM ION 著者 Hosfield, D.J, Greene, G.L, Fanning, S.W. 登録日 2022-03-31 公開日 2022-06-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.449 Å) 主引用文献 Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. Elife, 11, 2022
7UJF	Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Methylated Lasofoxifene Derivative with Selective Estrogen Receptor Degrader Properties 分子名称: (5R,6S)-5-(4-{2-[(3S)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-6-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol, Estrogen receptor 著者 Hosfield, D.J, Greene, G.L, Fanning, S.W. 登録日 2022-03-30 公開日 2022-06-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. Elife, 11, 2022
7UJY	Estrogen receptor alpha ligand binding domain Y537S mutant in complex with a methylated lasofoxifene derivative that enhances estrogen receptor alpha nuclear resonance time 分子名称: (5R,6S)-5-(4-{2-[(2R)-2-methylpyrrolidin-1-yl]ethoxy}phenyl)-6-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol, Estrogen receptor 著者 Hosfield, D.J, Greene, G.L, Fanning, S.W. 登録日 2022-03-31 公開日 2022-06-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. Elife, 11, 2022
7UJW	Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with a Methylated Lasofoxifene Derivative that Possesses Selective Estrogen Receptor Degrader Activities 分子名称: (5R,6S)-5-(4-{2-[(3S)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-6-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol, Estrogen receptor 著者 Hosfield, D.J, Greene, G.L, Fanning, S.W. 登録日 2022-03-31 公開日 2022-06-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. Elife, 11, 2022
7UJM	Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Methylated Lasofoxifene Derivative That Increases Receptor Resonance Time in the Nucleus of Breast Cancer Cells 分子名称: (5R,6S)-5-(4-{2-[(2R)-2-methylpyrrolidin-1-yl]ethoxy}phenyl)-6-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol, Estrogen receptor 著者 Hosfield, D.J, Greene, G.L, Fanning, S.W. 登録日 2022-03-31 公開日 2022-06-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. Elife, 11, 2022
4LDE	Structure of beta2 adrenoceptor bound to BI167107 and an engineered nanobody 分子名称: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Camelid Antibody Fragment, ... 著者 Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K. 登録日 2013-06-24 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody. Nature, 502, 2013
4LFQ	High resolution x-ray crystal structure of L-ShK toxin 分子名称: Potassium channel toxin ShK 著者 Dang, B, Kubota, T, Mandal, K, Bezanilla, F, Kent, S.B.H. 登録日 2013-06-27 公開日 2013-08-14 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (1.059 Å) 主引用文献 Native Chemical Ligation at Asx-Cys, Glx-Cys: Chemical Synthesis and High-Resolution X-ray Structure of ShK Toxin by Racemic Protein Crystallography. J.Am.Chem.Soc., 135, 2013
4LDL	Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody 分子名称: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 4-[(1R)-1-hydroxy-2-{[1-(4-hydroxyphenyl)-2-methylpropan-2-yl]amino}ethyl]benzene-1,2-diol, Camelid Antibody Fragment, ... 著者 Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K. 登録日 2013-06-24 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody. Nature, 502, 2013
2WTB	Arabidopsis thaliana multifuctional protein, MFP2 分子名称: FATTY ACID MULTIFUNCTIONAL PROTEIN (ATMFP2) 著者 Arent, S, Pye, V.E, Christensen, C.E, Norgaard, A, Henriksen, A. 登録日 2009-09-15 公開日 2010-05-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The Multi-Functional Protein in Peroxisomal Beta-Oxidation. Structure and Substrate Specificity of the Arabidopsis Thaliana Protein, Mfp2 J.Biol.Chem., 285, 2010
7VVT	SARS-CoV-2 3CL protease (3CLpro) in complex with a covalent inhibitor 分子名称: 3C-like proteinase, N-(3-chlorophenyl)-2-[(2R)-1-ethanoyl-3-oxidanylidene-piperazin-2-yl]ethanamide 著者 Su, H, Nie, T, Li, M, Xu, Y. 登録日 2021-11-08 公開日 2022-03-02 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 In silico screening-based discovery of novel covalent inhibitors of the SARS-CoV-2 3CL protease. Eur.J.Med.Chem., 231, 2022
3G1R	Crystal structure of human liver 5beta-reductase (AKR1D1) in complex with NADP and Finasteride. Resolution 1.70 A 分子名称: (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-tert-butyl-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide, 3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Di Costanzo, L, Drury, J.E, Penning, T.M, Christianson, D.W. 登録日 2009-01-30 公開日 2009-06-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.701 Å) 主引用文献 Inhibition of human steroid 5beta-reductase (AKR1D1) by finasteride and structure of the enzyme-inhibitor complex. J.Biol.Chem., 284, 2009
7U2A	Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA (GCU) 分子名称: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, RNA (38-MER), Serine--tRNA ligase, ... 著者 Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G. 登録日 2022-02-23 公開日 2022-09-14 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA. Nat Commun, 13, 2022
7U2I	Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... 著者 Syroegin, E.A, Aleksandrova, E.V, Polikanov, Y.S. 登録日 2022-02-24 公開日 2022-07-13 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structural basis for the inability of chloramphenicol to inhibit peptide bond formation in the presence of A-site glycine. Nucleic Acids Res., 50, 2022
4LDO	Structure of beta2 adrenoceptor bound to adrenaline and an engineered nanobody 分子名称: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, Camelid Antibody Fragment, L-EPINEPHRINE, ... 著者 Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K. 登録日 2013-06-24 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody. Nature, 502, 2013
2W6V	Structure of Human deoxy Hemoglobin A in complex with Xenon 分子名称: GLYCEROL, HEMOGLOBIN SUBUNIT ALPHA, HEMOGLOBIN SUBUNIT BETA, ... 著者 Miele, A.E, Draghi, F, Sciara, G, Johnson, K.A, Renzi, F, Vallone, B, Brunori, M, Savino, C. 登録日 2008-12-19 公開日 2009-04-28 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Pattern of Cavities in Globins: The Case of Human Hemoglobin. Biopolymers, 91, 2009
7VUF	Crystal Structure of the core region of Thermus thermophilus MutS2. 分子名称: DI(HYDROXYETHYL)ETHER, Endonuclease MutS2, MAGNESIUM ION 著者 Fukui, K, Yano, T. 登録日 2021-11-02 公開日 2022-04-06 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Structural and functional insights into the mechanism by which MutS2 recognizes a DNA junction. Structure, 30, 2022

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