7UJM
Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Methylated Lasofoxifene Derivative That Increases Receptor Resonance Time in the Nucleus of Breast Cancer Cells
Replaces: 7KCDReplaces: 6VNNSummary for 7UJM
| Entry DOI | 10.2210/pdb7ujm/pdb |
| Descriptor | Estrogen receptor, (5R,6S)-5-(4-{2-[(2R)-2-methylpyrrolidin-1-yl]ethoxy}phenyl)-6-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol (3 entities in total) |
| Functional Keywords | alpha helical bundle, hormone, estrogen receptor, breast cancer, transcription |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 4 |
| Total formula weight | 122046.49 |
| Authors | Hosfield, D.J.,Greene, G.L.,Fanning, S.W. (deposition date: 2022-03-31, release date: 2022-06-15, Last modification date: 2023-10-18) |
| Primary citation | Hosfield, D.J.,Weber, S.,Li, N.S.,Suavage, M.,Joiner, C.F.,Hancock, G.R.,Sullivan, E.A.,Ndukwe, E.,Han, R.,Cush, S.,Laine, M.,Mader, S.C.,Greene, G.L.,Fanning, S.W. Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. Elife, 11:-, 2022 Cited by PubMed: 35575456DOI: 10.7554/eLife.72512 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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