7UJM

Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Methylated Lasofoxifene Derivative That Increases Receptor Resonance Time in the Nucleus of Breast Cancer Cells

Replaces:  7KCDReplaces:  6VNN

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A, C, D	Estrogen receptor	polymer	262	30084.0	4	UniProt (P03372) Pfam (PF00104) In PDB	Homo sapiens (human)	ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
2	B, A, C, D	(5R,6S)-5-(4-{2-[(2R)-2-methylpyrrolidin-1-yl]ethoxy}phenyl)-6-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol	non-polymer		427.6	4	Chemie (RL4)
3		water	water		18.0	684	Chemie (HOH)

Sequence modifications

B, A, C, D: 307 - 554 (UniProt: P03372)

PDB	External Database	Details
His 293	-	expression tag
His 294	-	expression tag
His 295	-	expression tag
His 296	-	expression tag
His 297	-	expression tag
His 298	-	expression tag
Glu 299	-	expression tag
Asn 300	-	expression tag
Leu 301	-	expression tag
Tyr 302	-	expression tag
Gln 303	-	expression tag
Phe 304	-	expression tag
Ser 305	-	expression tag
Met 306	-	expression tag
Ser 381	Cys 381	engineered mutation
Ser 417	Cys 417	engineered mutation
Ser 530	Cys 530	engineered mutation
Ser 536	Leu 536	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	120336.2
Non-Polymers*	Number of molecules	4
	Total formula weight	1710.3
All*	Total formula weight	122046.5

*Water molecules are not included.