2NO3
| Novel 4-anilinopyrimidines as potent JNK1 Inhibitors | 分子名称: | 2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE, C-JUN-AMINO-TERMINAL KINASE-INTERACTING protein 1, Mitogen-activated protein kinase 8, ... | 著者 | Abad-Zapatero, C. | 登録日 | 2006-10-24 | 公開日 | 2007-04-17 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg.Med.Chem.Lett., 17, 2007
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4LTN
| Crystal structures of NADH:FMN oxidoreductase (EMOB) - FMN, NADH complex | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FLAVIN MONONUCLEOTIDE, NADH-dependent FMN reductase, ... | 著者 | Nissen, M.S, Youn, B, Knowles, B.D, Ballinger, J.W, Jun, S, Belchik, S.M, Xun, L, Kang, C. | 登録日 | 2013-07-23 | 公開日 | 2013-08-07 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.996 Å) | 主引用文献 | Crystal structures of NADH:FMN oxidoreductase (EmoB) at different stages of catalysis. J.Biol.Chem., 283, 2008
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4LTM
| Crystal structures of NADH:FMN oxidoreductase (EMOB) - FMN complex | 分子名称: | FLAVIN MONONUCLEOTIDE, NADH-dependent FMN reductase, SULFATE ION | 著者 | Nissen, M.S, Youn, B, Knowles, B.D, Ballinger, J.W, Jun, S, Belchik, S.M, Xun, L, Kang, C. | 登録日 | 2013-07-23 | 公開日 | 2013-08-07 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.497 Å) | 主引用文献 | Crystal structures of NADH:FMN oxidoreductase (EmoB) at different stages of catalysis. J.Biol.Chem., 283, 2008
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4LTD
| Crystal structures of NADH:FMN oxidoreductase (EMOB) - apo form | 分子名称: | NADH-dependent FMN reductase, PHOSPHATE ION, SULFATE ION | 著者 | Nissen, M.S, Youn, B, Knowles, B.D, Ballinger, J.W, Jun, S, Belchik, S.M, Xun, L, Kang, C. | 登録日 | 2013-07-23 | 公開日 | 2013-08-07 | 実験手法 | X-RAY DIFFRACTION (2.186 Å) | 主引用文献 | Crystal structures of NADH:FMN oxidoreductase (EmoB) at different stages of catalysis. J.Biol.Chem., 283, 2008
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4QJV
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4H39
| Crystal Structure of JNK3 in Complex with JIP1 Peptide | 分子名称: | C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 10 | 著者 | Nwachukwu, J.C, Laughlin, J.D, Figuera-Losada, M, Cherry, L, Nettles, K.W, LoGrasso, P.V. | 登録日 | 2012-09-13 | 公開日 | 2012-11-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.992 Å) | 主引用文献 | Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases. Structure, 20, 2012
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1IUP
| meta-Cleavage product hydrolase from Pseudomonas fluorescens IP01 (CumD) S103A mutant complexed with isobutyrates | 分子名称: | 2-METHYL-PROPIONIC ACID, meta-Cleavage product hydrolase | 著者 | Fushinobu, S, Saku, T, Hidaka, M, Jun, S.-Y, Nojiri, H, Yamane, H, Shoun, H, Omori, T, Wakagi, T. | 登録日 | 2002-03-06 | 公開日 | 2002-09-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structures of a meta-cleavage product hydrolase from Pseudomonas
fluorescens IP01 (CumD) complexed with cleavage products PROTEIN SCI., 11, 2002
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1IUO
| meta-Cleavage product hydrolase from Pseudomonas fluorescens IP01 (CumD) S103A mutant complexed with acetates | 分子名称: | ACETATE ION, meta-Cleavage product hydrolase | 著者 | Fushinobu, S, Saku, T, Hidaka, M, Jun, S.-Y, Nojiri, H, Yamane, H, Shoun, H, Omori, T, Wakagi, T. | 登録日 | 2002-03-06 | 公開日 | 2002-09-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of a meta-cleavage product hydrolase from Pseudomonas
fluorescens IP01 (CumD) complexed with cleavage products PROTEIN SCI., 11, 2002
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1IUN
| meta-Cleavage product hydrolase from Pseudomonas fluorescens IP01 (CumD) S103A mutant hexagonal | 分子名称: | ACETATE ION, meta-Cleavage product hydrolase | 著者 | Fushinobu, S, Saku, T, Hidaka, M, Jun, S.-Y, Nojiri, H, Yamane, H, Shoun, H, Omori, T, Wakagi, T. | 登録日 | 2002-03-06 | 公開日 | 2002-09-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structures of a meta-cleavage product hydrolase from Pseudomonas
fluorescens IP01 (CumD) complexed with cleavage products PROTEIN SCI., 11, 2002
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6U7V
| xRRM structure of spPof8 | 分子名称: | NITRATE ION, Protein pof8 | 著者 | Kim, J.-K, Hu, X, Yu, C, Jun, H.-I, Liu, J, Sankaran, B, Huang, L, Qiao, F. | 登録日 | 2019-09-03 | 公開日 | 2020-09-09 | 最終更新日 | 2021-03-24 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Quality-Control Mechanism for Telomerase RNA Folding in the Cell. Cell Rep, 33, 2020
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1MQ8
| Crystal structure of alphaL I domain in complex with ICAM-1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin alpha-L, ... | 著者 | Shimaoka, M, Xiao, T, Liu, J.-H, Yang, Y, Dong, Y, Jun, C.-D, McCormack, A, Zhang, R, Joachimiak, A, Takagi, J, Wang, J.-H, Springer, T.A. | 登録日 | 2002-09-15 | 公開日 | 2003-01-14 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structures of the aL I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation Cell(Cambridge,Mass.), 112, 2003
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6Y3V
| 14-3-3 Sigma in complex with phosphorylated c-Jun peptide | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, MAGNESIUM ION, ... | 著者 | Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. | 登録日 | 2020-02-19 | 公開日 | 2020-10-14 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.499 Å) | 主引用文献 | A new soaking procedure for X-ray crystallographic structural determination of protein-peptide complexes. Acta Crystallogr.,Sect.F, 76, 2020
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3KVX
| JNK3 bound to aminopyrimidine inhibitor, SR-3562 | 分子名称: | Mitogen-activated protein kinase 10, N-[(2Z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1H)-ylidene]-4-(3-morpholin-4-yl-1H-1,2,4-triazol-1-yl)aniline | 著者 | Habel, J.E, Laughlin, J.D, LoGrasso, P. | 登録日 | 2009-11-30 | 公開日 | 2009-12-22 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors J.Med.Chem., 53, 2010
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1IC2
| DECIPHERING THE DESIGN OF THE TROPOMYOSIN MOLECULE | 分子名称: | TROPOMYOSIN ALPHA CHAIN, SKELETAL MUSCLE | 著者 | Brown, J.H, Kim, K.-H, Jun, G, Greenfield, N.J, Dominguez, R, Volkmann, N, Hitchcock-DeGregori, S.E, Cohen, C. | 登録日 | 2001-03-29 | 公開日 | 2001-07-25 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Deciphering the design of the tropomyosin molecule Proc.Natl.Acad.Sci.USA, 98, 2001
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3FV8
| JNK3 bound to piperazine amide inhibitor, SR2774. | 分子名称: | 1,2-ETHANEDIOL, 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide, Mitogen-activated protein kinase 10 | 著者 | Habel, J.E. | 登録日 | 2009-01-15 | 公開日 | 2009-04-07 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
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1DEQ
| THE CRYSTAL STRUCTURE OF MODIFIED BOVINE FIBRINOGEN (AT ~4 ANGSTROM RESOLUTION) | 分子名称: | FIBRINOGEN, FIBRINOGEN (ALPHA CHAIN), FIBRINOGEN (BETA CHAIN), ... | 著者 | Brown, J.H, Volkmann, N, Jun, G, Henschen-Edman, A.H, Cohen, C. | 登録日 | 1999-11-15 | 公開日 | 2000-02-02 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | The crystal structure of modified bovine fibrinogen. Proc.Natl.Acad.Sci.USA, 97, 2000
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2QHB
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8D4P
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8FTL
| Crystal structure of the SARS-CoV-2 (COVID-19) main protease (Mpro) in complex with inhibitor Jun89-3-C1 | 分子名称: | 3C-like proteinase nsp5, N-([1,1'-biphenyl]-4-yl)-2-chloro-N-[(1R)-2-oxo-2-{[(1S)-1-phenylethyl]amino}-1-(pyridin-3-yl)ethyl]acetamide | 著者 | Lewandowski, E.M, Butler, S.G, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2023-01-12 | 公開日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Crystal structure of the SARS-CoV-2 (COVID-19) main protease (Mpro) in complex with inhibitor Jun89-3-C1 To Be Published
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3U85
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3U88
| Crystal structure of human menin in complex with MLL1 and LEDGF | 分子名称: | (4beta,8alpha,9R)-6'-methoxy-10,11-dihydrocinchonan-9-ol, CHOLIC ACID, GLYOXYLIC ACID, ... | 著者 | Huang, J, Wan, B, Lei, M. | 登録日 | 2011-10-16 | 公開日 | 2012-02-15 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature, 482, 2012
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3U84
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4CK5
| Pseudo-atomic model of microtubule-bound human kinesin-5 motor domain in the ADP state, based on cryo-electron microscopy experiment. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Goulet, A, Major, J, Jun, Y, Gross, S, Rosenfeld, S, Moores, C. | 登録日 | 2013-12-30 | 公開日 | 2014-02-05 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (10 Å) | 主引用文献 | Comprehensive Structural Model of the Mechanochemical Cycle of a Mitotic Motor Highlights Molecular Adaptations in the Kinesin Family. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CK6
| Pseudo-atomic model of microtubule-bound human kinesin-5 motor domain in the ADP.AlFx state, based on cryo-electron microscopy experiment. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Goulet, A, Major, J, Jun, Y, Gross, S, Rosenfeld, S, Moores, C. | 登録日 | 2013-12-30 | 公開日 | 2014-02-05 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (9.2 Å) | 主引用文献 | Comprehensive Structural Model of the Mechanochemical Cycle of a Mitotic Motor Highlights Molecular Adaptations in the Kinesin Family. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CK7
| Pseudo-atomic model of microtubule-bound human kinesin-5 motor domain in presence of adp.alfx (NECK-LINKER IN ITS DISCONNECTED CONFORMATION, based on cryo-electron microscopy experiment | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Goulet, A, Major, J, Jun, Y, Gross, S, Rosenfeld, S, Moores, C. | 登録日 | 2013-12-30 | 公開日 | 2014-02-05 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (9.2 Å) | 主引用文献 | Comprehensive Structural Model of the Mechanochemical Cycle of a Mitotic Motor Highlights Molecular Adaptations in the Kinesin Family. Proc.Natl.Acad.Sci.USA, 111, 2014
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