1MQ8

Crystal structure of alphaL I domain in complex with ICAM-1

Summary for 1MQ8

Related1MQ9 1MQA
Descriptorintercellular adhesion molecule-1, Integrin alpha-L, N-ACETYL-D-GLUCOSAMINE, ... (5 entities in total)
Functional Keywordsig superfamily, rossmann fold, metal mediated protein interface, immune system
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein P05362 P20701
Total number of polymer chains4
Total molecular weight106333
Authors
Shimaoka, M.,Xiao, T.,Liu, J.-H.,Yang, Y.,Dong, Y.,Jun, C.-D.,McCormack, A.,Zhang, R.,Joachimiak, A.,Takagi, J.,Wang, J.-H.,Springer, T.A. (deposition date: 2002-09-15, release date: 2003-01-14, Last modification date: 2011-07-13)
Primary citation
Shimaoka, M.,Xiao, T.,Liu, J.-H.,Yang, Y.,Dong, Y.,Jun, C.-D.,McCormack, A.,Zhang, R.,Joachimiak, A.,Takagi, J.,Wang, J.-H.,Springer, T.A.
Structures of the aL I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation
Cell(Cambridge,Mass.), 112:99-111, 2003
PubMed: 12526797 (PDB entries with the same primary citation)
DOI: 10.1016/S0092-8674(02)01257-6
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.3 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers344.8%10.9%3.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1mq8
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Molmil generated image of 1mq8
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More Biological unit images

Molmil generated image of 1mq8
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Molmil generated image of 1mq8
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Molmil generated image of 1mq8
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1mq8.pdb1.gz [56.57 KB])
Coordinate files for Biological unit (1mq8.pdb2.gz [57.24 KB])