1MQ8
Crystal structure of alphaL I domain in complex with ICAM-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | intercellular adhesion molecule-1 | polymer | 291 | 31623.8 | 2 | UniProt (P05362) Pfam (PF03921) Pfam (PF21146) In PDB | Homo sapiens (human) | ICAM-1; CD54 antigen; Major group rhinovirus receptor |
| 2 | B, D | Integrin alpha-L | polymer | 177 | 20191.2 | 2 | UniProt (P20701) Pfam (PF00092) In PDB | Homo sapiens (human) | Leukocyte adhesion glycoprotein LFA-1 alpha chain; Leukocyte function associated molecule 1, alpha chain; CD11a |
| 3 | E, F, G, H | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 4 | A, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 5 | B, D | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
B, D: 130 - 306 (UniProt: P20701)
| PDB | External Database | Details |
|---|---|---|
| Cys 161 | Leu 186 | engineered mutation |
| Cys 299 | Phe 324 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 103629.9 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1697.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 933.4 | |
| All* | Total formula weight | 106260.9 |
