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5WWK
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Highly stable green fluorescent protein
分子名称: Green fluorescent protein
著者Sriram, R, George, A, Kesavan, M, Jaimohan, S.M, Kamini, N.R, Easwaramoorthi, S, Ganesh, S, Gunasekaran, K, Ayyadurai, N.
登録日2017-01-02
公開日2017-12-13
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.199 Å)
主引用文献Excited State Electronic Interconversion and Structural Transformation of Engineered Red-Emitting Green Fluorescent Protein Mutant.
J.Phys.Chem.B, 123, 2019
5WX5
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Alkylquinolone synthase Y215V mutant from Evodia rutaecarpa
分子名称: Alkylquinolone synthase
著者Matsui, T, Kodama, T, Tadakoshi, T, Morita, H.
登録日2017-01-06
公開日2017-04-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.058 Å)
主引用文献2-Alkylquinolone alkaloid biosynthesis in the medicinal plant Evodia rutaecarpa involves collaboration of two novel type III polyketide synthases
J. Biol. Chem., 292, 2017
5WDH
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BU of 5wdh by Molmil
Motor domain of human kinesin family member C1
分子名称: ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIFC1, MAGNESIUM ION, ...
著者Zhu, H, Tempel, W, He, H, Shen, Y, Wang, J, Brothers, G, Landry, R, Arrowsmith, C.H, Edwards, A.M, Park, H, Structural Genomics Consortium (SGC)
登録日2017-07-05
公開日2017-08-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.248 Å)
主引用文献Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein.
Sci Rep, 7, 2017
5WDP
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H-Ras mutant L120A bound to GMP-PNP at 277K
分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ...
著者Cofsky, J.C, Bandaru, P, Gee, C.L, Kuriyan, J.
登録日2017-07-05
公開日2017-07-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Deconstruction of the Ras switching cycle through saturation mutagenesis.
Elife, 6, 2017
4WTY
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BU of 4wty by Molmil
Structure of the PTP-like myo-inositol phosphatase from Selenomonas ruminantium in complex with myo-inositol-(1,3,4,5)-tetrakisphosphate
分子名称: CHLORIDE ION, GLYCEROL, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, ...
著者Bruder, L.M, Mosimann, S.C.
登録日2014-10-30
公開日2015-11-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of the PTP-like phytase from Selenomonas ruminantium in complex with myo-inositol-(1,3,4,5)-tetrakisphosphate
To Be Published
4WU3
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BU of 4wu3 by Molmil
Structure of the PTP-like myo-inositol phosphatase from Mitsuokella multacida in complex with myo-inositol-(1,3,4,5)-tetrakisphosphate
分子名称: GLYCEROL, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, MYO-INOSITOL PHOSPHOHYDROLASE, ...
著者Bruder, L.M, Mosimann, S.C.
登録日2014-10-30
公開日2015-12-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of the PTP-like phytase from Selenomonas ruminantium in complex with myo-inositol-(1,3,4,5)-tetrakisphosphate
To Be Published
4WG4
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BU of 4wg4 by Molmil
Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1613
分子名称: 3-(7-ethoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
著者Merritt, E.A.
登録日2014-09-17
公開日2014-10-15
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1613
to be published
5WDE
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Crystal structure of the KIFC3 motor domain in complex with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIFC3, MAGNESIUM ION, ...
著者Shen, Y, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Park, H, Structural Genomics Consortium (SGC)
登録日2017-07-05
公開日2017-08-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein.
Sci Rep, 7, 2017
5WIK
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JAK2 Pseudokinase in complex with BI-D1870
分子名称: (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one, Tyrosine-protein kinase JAK2
著者Li, Q, Eck, M.J, Li, K, Park, E.
登録日2017-07-19
公開日2018-08-01
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain.
ACS Chem. Biol., 14, 2019
5WIM
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JAK2 Pseudokinase in complex with AT9283
分子名称: 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea, Tyrosine-protein kinase JAK2
著者Li, Q, Eck, M.J, Li, K, Park, E.
登録日2017-07-19
公開日2018-08-01
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain.
ACS Chem. Biol., 14, 2019
5WI6
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BU of 5wi6 by Molmil
Human beta-1 tryptase mutant Ile99Cys
分子名称: L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, SULFATE ION, Tryptase alpha/beta-1
著者Eigenbrot, C, Maun, H.R.
登録日2017-07-18
公開日2018-04-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Dual functionality of beta-tryptase protomers as both proteases and cofactors in the active tetramer.
J. Biol. Chem., 293, 2018
5WIJ
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JAK2 Pseudokinase in complex with NU6140
分子名称: 4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N-diethylbenzamide, Tyrosine-protein kinase JAK2
著者Li, Q, Eck, M.J, Li, K, Park, E.
登録日2017-07-19
公開日2018-08-01
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain.
ACS Chem. Biol., 14, 2019
5WIL
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JAK2 Pseudokinase in complex with AZD7762
分子名称: 5-(3-fluorophenyl)-N-[(3S)-3-piperidyl]-3-ureido-thiophene-2-carboxamide, Tyrosine-protein kinase JAK2
著者Li, Q, Eck, M.J, Li, K, Park, E.
登録日2017-07-19
公開日2018-08-01
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain.
ACS Chem. Biol., 14, 2019
5WIZ
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Phosphotriesterase variant S5
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase, ...
著者Miton, C.M, Campbell, E.C, Jackson, C.J, Tokuriki, N.
登録日2017-07-21
公開日2019-01-23
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Phosphotriesterase variant S5
To Be Published
5WJO
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Crystal structure of the unliganded PG90 TCR
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, PG90 TCR alpha chain, ...
著者Shahine, A, Gras, S, Rossjohn, J.
登録日2017-07-24
公開日2017-10-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A molecular basis of human T cell receptor autoreactivity toward self-phospholipids.
Sci Immunol, 2, 2017
4WSE
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Crystal structure of the Mimivirus polyadenylate synthase
分子名称: Putative poly(A) polymerase catalytic subunit
著者Priet, S, Lartigue, A, Claverie, J.M, Abergel, C.
登録日2014-10-27
公開日2015-04-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献mRNA maturation in giant viruses: variation on a theme.
Nucleic Acids Res., 43, 2015
4WSJ
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Crystal structure of a bacterial fucodiase in complex with 1-((1R,2R,3R,4R,5R,6R)-2,3,4-trihydroxy-5-methyl-7-azabicyclo[4.1.0]heptan-7-yl)ethan-1-one
分子名称: Alpha-L-fucosidase, N-[(1S,2R,3R,4S,5R)-3,4,5-trihydroxy-2-methylcyclohexyl]acetamide, SULFATE ION
著者Davies, G.J, Wright, D.W.
登録日2014-10-28
公開日2014-11-05
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献In vitroandin vivocomparative and competitive activity-based protein profiling of GH29 alpha-l-fucosidases.
Chem Sci, 6, 2015
5WL0
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Co-crystal structure of Influenza A H3N2 PB2 (241-741) bound to VX-787
分子名称: (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, DI(HYDROXYETHYL)ETHER, Polymerase basic protein 2
著者Ma, X, Shia, S.
登録日2017-07-25
公開日2017-09-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit.
Sci Rep, 7, 2017
5WLI
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Crystal Structure of H-2Db with the GAP501 peptide (SQL)
分子名称: Beta-2-microglobulin, GAP50 peptide, H-2 class I histocompatibility antigen, ...
著者Gras, S, Farenc, C, Josephs, T, Rossjohn, J.
登録日2017-07-27
公開日2017-11-15
最終更新日2019-05-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene.
Immunity, 47, 2017
4WLP
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Crystal structure of UCH37-NFRKB Inhibited Deubiquitylating Complex
分子名称: Nuclear factor related to kappa-B-binding protein, Ubiquitin carboxyl-terminal hydrolase isozyme L5
著者Hemmis, C.W, Hill, C.P, VanderLinden, R, Whitby, F.G.
登録日2014-10-07
公開日2015-03-04
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.102 Å)
主引用文献Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase.
Mol.Cell, 57, 2015
4WFC
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BU of 4wfc by Molmil
Structure of the Rrp6-Rrp47 interaction
分子名称: Exosome complex exonuclease RRP6, Exosome complex protein LRP1, SULFATE ION
著者Schuch, B, Conti, E.
登録日2014-09-14
公開日2014-10-29
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase.
Embo J., 33, 2014
4WFL
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BU of 4wfl by Molmil
Structure of the complete bacterial SRP Alu domain
分子名称: COBALT HEXAMMINE(III), MAGNESIUM ION, RNA
著者Kempf, G, Wild, K, Sinning, I.
登録日2014-09-15
公開日2014-10-15
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Structure of the complete bacterial SRP Alu domain.
Nucleic Acids Res., 42, 2014
4WH0
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YcaC from Pseudomonas aeruginosa with S-mercaptocysteine active site cysteine
分子名称: CHLORIDE ION, Putative hydrolase
著者Groftehauge, M.K, Truan, D, Vasil, A, Denny, P.W, Vasil, M.L, Pohl, E.
登録日2014-09-19
公開日2015-07-29
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.563 Å)
主引用文献Crystal Structure of a Hidden Protein, YcaC, a Putative Cysteine Hydrolase from Pseudomonas aeruginosa, with and without an Acrylamide Adduct.
Int J Mol Sci, 16, 2015
5WUE
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Structural basis for conductance through TRIC cation channels
分子名称: SULFATE ION, Uncharacterized protein
著者Su, M, Gao, F, Mao, Y, Li, D.L, Guo, Y.Z, Wang, X.H, Bruni, R, Kloss, B, Hendrickson, W.A, Chen, Y.H, New York Consortium on Membrane Protein Structure (NYCOMPS)
登録日2016-12-17
公開日2017-06-21
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for conductance through TRIC cation channels.
Nat Commun, 8, 2017
5WUU
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Complex structure of the first bromodomain of BRD4 with an inhibitor that containing a 2H-chromen-2-one ring
分子名称: Bromodomain-containing protein 4, ~{N}-methyl-~{N}-[3-[(2-oxidanylidenechromen-4-yl)amino]propyl]thiophene-2-carboxamide
著者Zhang, H, Sun, Z.Y.
登録日2016-12-21
公開日2017-04-12
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.724 Å)
主引用文献Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays.
Bioorg. Med. Chem. Lett., 27, 2017

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