4WLP

Crystal structure of UCH37-NFRKB Inhibited Deubiquitylating Complex

Summary for 4WLP

Entry DOI	10.2210/pdb4wlp/pdb
Related	4WLQ 4WLR
Descriptor	Ubiquitin carboxyl-terminal hydrolase isozyme L5, Nuclear factor related to kappa-B-binding protein (2 entities in total)
Functional Keywords	uch37 nfrkb proteasome ino80 dub, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	49954.56
Authors	Hemmis, C.W.,Hill, C.P.,VanderLinden, R.,Whitby, F.G. (deposition date: 2014-10-07, release date: 2015-03-04, Last modification date: 2023-12-27)
Primary citation	VanderLinden, R.T.,Hemmis, C.W.,Schmitt, B.,Ndoja, A.,Whitby, F.G.,Robinson, H.,Cohen, R.E.,Yao, T.,Hill, C.P. Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase. Mol.Cell, 57:901-911, 2015 Cited by PubMed: 25702872 DOI: 10.1016/j.molcel.2015.01.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.102 Å)

Structure validation